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This article discusses the potential role of oral DHEA, available as a 'dietary supplement' in the US, in COVID-19 morbidity and mortality, calling for clinical trials to assess its safety.

This study found that a daily dose of 50 mg DHEA only slightly increased the urinary testosterone/epitestosterone ratio for a short period, without exceeding the IOC's acceptable limit.

This study found that switching juvenile mice from a high-fat, high-carbohydrate diet to a control diet optimally reduced hormonal imbalances and weight, with nutraceuticals offering partial support.

Low DHEA-S levels might be linked to alopecia areata and could be a potential treatment target.

This study observed that herbal feed supplementation in Frieswal breeding bulls improved semen volume and motility, while significantly lowering dihydrotestosterone levels, suggesting a potential mechanism for enhancing semen quality.

This review discusses how the HSD3B1(1245C) genotype may impact androgen physiology and the progression of castration-resistant prostate cancer, and does not report new experimental results.

In this study, 50 mg/day of DHEA supplementation in postmenopausal women did not significantly improve sexual function compared to a placebo over 26 weeks.

This investigation found that certain supplements, particularly whey protein isolate, growth hormones, and anabolic steroids, can negatively impact hair loss by affecting biochemical pathways.

This article reviews the clinical signs, diagnostic approaches, and treatment options for hyperandrogenism in women, focusing on hirsutism and specifies that cyproterone acetate is effective for severe cases, but reports no new clinical results.

This study found that taking a daily oral dose of 50mg DHEA for one year had no significant impact on blood lipids, insulin sensitivity, or the endometrium in postmenopausal women with low libido.

This report describes an exceptionally rare adrenal neoplasm in a post-menopausal woman that exclusively secreted DHEA-S, with significant serum level reduction following adrenalectomy.

This case study reported a unique instance of a benign adrenal adenoma co-secreting cortisol and DHEA-S, which initially mimicked PCOS symptoms. Surgical removal resulted in significant clinical improvement, confirming the diagnosis of cyclic adrenal Cushing's syndrome.

This case study describes a man with long-standing alopecia universalis who experienced hair regrowth after taking testosterone, chorionic gonadotropin, and DHEA-S.

This review discusses how dehydroepiandrosterone (DHEA) may exert its biological effects through multiple receptors and reports no new clinical results.

In this case study, a six-year-old girl was diagnosed with isolated adrenarche, linked to premature adrenal maturation, with increased dehydroepiandrosterone sulfate and axillary and pubic hair growth, and will require long-term monitoring due to increased risks of conditions like polycystic ovary syndrome and cardiovascular diseases.

In this study, researchers examined the genetic factors impacting cortisol and DHEA concentrations in the hair of healthy pigs; they found that cortisol levels were heritable and genetically correlated with behavioral stress responses, suggesting these hormones could potentially serve as indicators for selecting disease-resilient pigs.

This case study suggests that long-term treatment with buprenorphine/naloxone for opioid addiction may lead to secondary adrenal insufficiency, warranting further investigation.

This case study reports a rare instance of a virilizing androgen-only secreting adrenal cortical adenoma in a 13-year-old, with symptom resolution after surgical removal.

This case study highlights the complexity of managing PCOS and its symptoms in transmen, suggesting hormonal fluctuations may lead to symptomatic relief with low dose estradiol.

This report presents a rare case of suspected 3β HSD deficiency in an adult female with symptoms like male pattern hair loss and low testosterone, suggesting a non-classical presentation.

Among postmenopausal women, this case study observed that a rare ovarian tumor called thecoma, found via MRI, was associated with high testosterone levels and symptoms of mild virilization such as hirsutism, indicating surgery as the primary treatment.

This case report describes a 23-year-old woman with an adult granulosa cell tumor of the ovary, whose symptoms and hormone levels improved significantly after surgical removal of the tumor.

This case report describes a 47-year-old woman diagnosed with a rare Sertoliform endometrioid carcinoma of the ovary, emphasizing its early-stage presentation and generally favorable prognosis.

This case report describes a rare occurrence of giant bilateral adrenal myelolipomas in a 28-year-old female with CAH, emphasizing that large, hormonally active, or painful myelolipomas should be surgically removed.

This case report emphasizes the importance of early diagnosis of Swyer Syndrome in adolescents with slow pubertal progression and primary amenorrhea due to the high risk of germ cell cancers.

This meta-analysis found that chromium supplementation was associated with decreased insulin resistance but increased testosterone levels in women with PCOS, with no significant benefits for other metabolic or hormonal indexes.

This review found that chromium supplementation has limited effects on weight reduction, glucose control, lipid profile, and hormonal balance in women with PCOS, highlighting the need for further research.

This study found that recruiting healthy naturally menopausal women for a DHEA therapy trial was challenged by concerns about hormonal treatments and time constraints, impacting study feasibility.

In this study, researchers observed that DHEA-induced PCOS rats experienced significant changes in gut microbiota and metabolic profiles, particularly affecting steroid and lipid metabolism, suggesting the gut-ovary axis may play a role in the pathogenesis of PCOS.

This review underscores the importance of phytotherapeutic compounds and adjuncts in managing polycystic ovarian syndrome but does not present new clinical evidence.