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This study reports the development of novel 4-amido-Δ4,6-steroids as potential inhibitors of 5α-reductase, showing promising in vitro results for conditions like acne and benign prostatic cancer.

This study found that epitestosterone, a stereoisomer of testosterone, is metabolized to 5α-dihydroepitestosterone by human 5α-reductase enzymes, which enhances its androgenic activity and reduces its antagonistic effect on testosterone-driven androgen receptor signaling.

This study suggests that finasteride may inhibit the enzyme phenylethanolamine N-methyltransferase, which could contribute to its sexual and psychological side effects.

In this study, daily administration of 100mg DHEA for 16 weeks in women with adequate ovarian reserve did not modify metabolic or reproductive variables, apart from increased antral follicular count and anti-Müllerian hormone levels.

This review proposes focusing on relationships between neuroactive steroids and psychiatric disorder symptoms, rather than relying on traditional disorder classifications, and reports no new clinical findings.

Androstenedione, a hormone supplement, doesn't improve muscle or performance and can cause harmful side effects.

This review discusses various psychiatric treatments including antipsychotics, insomnia medication, and mood stabilizers, but reports no new clinical results; the authors comment on existing findings and approvals.

In this study, researchers found that female rats exhibited more pronounced panic-related escape behavior during hypoxia, particularly in the diestrus phase, and that low-dose fluoxetine reduced this behavior, suggesting its potential for managing panic disorder symptoms related to hormonal cycles in women.

Neurosteroids may help metyrapone reduce cocaine addiction.

This study observed that higher childhood levels of DHEAS were associated with more advanced pubertal development and correlated with changes in DNA methylation near puberty-related genes in both boys and girls, potentially explaining the hormone's influence on puberty.

This study models the pathways of nandrolone and its metabolites in the body and suggests methods to counteract finasteride's role in enabling PED users to cheat drug tests.

In this study, two different estroprogestin treatments significantly improved skin conditions and decreased androgen levels in hyperandrogenic women, with EE/DRSP showing more pronounced hormonal changes and skin improvements compared to EE/CMA.

In this research, caffeine's versatile pharmacological actions were highlighted, demonstrating its stimulant, bronchodilator, diuretic, and potential anticancer effects through interactions with adenosine receptors, phosphodiesterase, and renal tubules, revealing valuable insights for drug development and therapeutic applications in medicine.

This case report describes a 35-year-old man who developed an atypical DRESS syndrome after taking topiramate for migraine prevention, which resolved with drug withdrawal and symptomatic treatment.

This study found that acute sleep deprivation enhanced 5α-reductase expression and activity in the rat prefrontal cortex, and finasteride treatment reduced associated psychosis- and mania-like behaviors.

This study developed and validated a high-resolution mass spectrometry method to screen for prohibited substances and analyze six endogenous steroids in urine according to World Antidoping Agency requirements, demonstrating its effectiveness for antidoping analysis.

Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

This study found that two novel nonsteroidal derivatives inhibited specific enzymes in vitro and in vivo, leading to dihydrotestosterone accumulation in androgen-dependent glands, suggesting potential therapeutic use for mood improvement in the elderly.

This study found that dutasteride may offer neuroprotection in early-stage Parkinson's disease by preventing loss of striatal dopamine and altering steroid levels in MPTP-lesioned mice.

This study found that the topical application of DA-OTC-002, a combination of synephrine and tyramine hydrochloride, significantly reduced immediate hair shedding in women by 62.5% compared to a placebo, without any observed adverse effects.

This study found that bupropion SR may improve symptoms in female trichotillomania patients who did not respond to SSRIs, with benefits maintained through a 16-month follow-up.

This case study reported a unique instance of a benign adrenal adenoma co-secreting cortisol and DHEA-S, which initially mimicked PCOS symptoms. Surgical removal resulted in significant clinical improvement, confirming the diagnosis of cyclic adrenal Cushing's syndrome.

This study reported the development of two highly sensitive ELISA assays to detect banned substances finasteride and dutasteride in human urine, offering better sensitivity than existing HPLC/MS/MS methods.

In this study, researchers addressed the limitations of adenosine's practical application in treating inflammation, oxidative stress, and tissue repair due to its poor water solubility and low transdermal permeability. Results are not reported in the abstract.

This study developed and validated a sensitive and rapid method to simultaneously measure alfuzosin and dutasteride in human plasma, enabling high-throughput analysis for pharmacokinetic and bioequivalence studies.

This study found that MENT is 10 times more potent than testosterone in suppressing gonadotropins and contributing to anabolism in monkeys, with a potentially wider therapeutic index for human androgen replacement and male contraception.

This study found that dopamine directly induces the catagen phase in human scalp hair follicles in vitro.

In this study, chronic exposure to finasteride induced metabolic disturbances and depression-like behaviors in young male rats, similar to those caused by obesity, but did not worsen anxiety or depression in obese rats.

This paper describes a new scalable synthesis method for Dutasteride, highlighting its potential for large-scale commercial production.

This study found that estazolam improved PTSD-like behavior deficits in an animal model, which was linked to increased allopregnanolone levels in specific brain regions.