TLDR The document concludes that finasteride can reduce nandrolone detection in doping tests, suggesting frequent testing and setting metabolite level thresholds for detection.
The document presents a model simulating the pharmacodynamics of the performance-enhancing drug nandrolone and its interaction with finasteride, a drug used to prevent male hair loss. The model, tested against data from two studies involving 28 volunteers in total, accurately represented the pharmacokinetics of nandrolone and the dynamic effects of finasteride. It showed that finasteride can decrease the excretion of a nandrolone metabolite to 30 percent and last around 12 days, potentially allowing athletes to avoid detection in doping tests. The study recommends that the World Anti-Doping Agency conduct frequent tests and establish a threshold for certain metabolite levels to detect nandrolone users. The model can be used by anti-doping agencies to predict short-term metabolite dynamics of athletes.
16 citations,
January 2010 in “Drug Metabolism and Pharmacokinetics” Finasteride's effect on hair loss and prostate enlargement depends on its binding to an enzyme, with maximum impact at 0.2 mg dose.
39 citations,
April 2007 in “Therapeutic Drug Monitoring” Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.
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June 2006 in “Journal of The American Academy of Dermatology” Finasteride increases hair weight and count in men with hair loss, with best results after four years.
137 citations,
March 2006 in “Cns Drug Reviews” Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.
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October 2010 in “Pharmacogenomics” Researchers found that most genes affecting drug responses are not fully covered by commercial SNP chips, suggesting the need for more comprehensive tools to optimize drug selection based on genetics.
October 2020 in “Authorea (Authorea)” Men and women react differently to opioids, with hormones potentially influencing these differences.
3 citations,
January 2016 in “Elsevier eBooks” Steroid hormones are crucial for body functions and have various medical uses, but their misuse can lead to dependence.
The conclusion is that endocrinology significantly impacts medicine with various common medications used for treatment.
1 citations,
January 2024 in “Curēus” Clinicians should use social and prescription data to track trends in performance-enhancing drug use.
