Association of Childhood Dehydroepiandrosterone Sulfate Concentration, Pubertal Development, and DNA Methylation at Puberty-Related Genes

November 2024 in “ European Journal of Endocrinology ”

Sudman, Maya, Stöger, Reinhard, Melamed Philippa, Bentley, Gillian R

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Research cited in this study

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research Mechanisms of Action of Dehydroepiandrosterone

35 citations , January 2018 in “Vitamins and hormones”

DHEA affects various tissues by interacting with multiple receptors and can be converted into sex hormones.

research 5α-Reductase Activity in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

20 citations , March 2017 in “Reproductive Biology and Endocrinology”

Women with PCOS have higher 5α-reductase activity, which may be linked to insulin resistance.

research Clinical and Biochemical Characteristics in PCOS Women With Menstrual Abnormalities

3 citations , December 2016 in “PubMed”

Menstrual abnormalities in PCOS women may not greatly affect their metabolic and hormonal profile.

research Evidence for Increased 5α-Reductase Activity During Early Childhood in Daughters of Women With Polycystic Ovary Syndrome

40 citations , March 2016 in “The Journal of Clinical Endocrinology & Metabolism”

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)

4025 citations , December 2003 in “Human Reproduction”

The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.