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research Polycystic Ovary Syndrome Is Linked With the Fat Mass Obesity (FTO) Gene Variants rs17817449 and rs1421085 in Western Saudi Arabia

2 citations , October 2021 in “Bioinformation”

Certain gene variants are linked to a higher risk of polycystic ovary syndrome, hair loss, and obesity in women from western Saudi Arabia.

Exosome-Derived Long Non-Coding RNA AC010789.1 Modified by FTO and hnRNPA2B1 Accelerates Growth of Hair Follicle Stem Cells Against Androgen Alopecia by Activating S100A8/Wnt/β-Catenin Signaling

research Exosome-Derived Long Non-Coding RNA AC010789.1 Modified by FTO and hnRNPA2B1 Accelerates Growth of Hair Follicle Stem Cells Against Androgen Alopecia by Activating S100A8/Wnt/β-Catenin Signaling

January 2025 in “Clinical and Translational Medicine”

A specific RNA can help hair growth in baldness by boosting stem cell activity.

research Obesity and Polycystic Ovary Syndrome: Implications for Pathogenesis and Novel Management Strategies

129 citations , January 2019 in “Clinical medicine insights”

Obesity worsens PCOS symptoms, and PCOS may lead to more weight gain; managing both requires a holistic approach that includes mental health.

research NUDT15, FTO, and RUNX1 Genetic Variants and Thiopurine Intolerance Among Japanese Patients With Inflammatory Bowel Diseases

40 citations , January 2017 in “Intestinal Research”

Genotyping for NUDT15 p.Arg139Cys can help predict thiopurine side effects in Japanese IBD patients.

research Genetic Basis of Polycystic Ovary Syndrome

18 citations , July 2010 in “Expert Review of Endocrinology & Metabolism”

The document concludes that PCOS has a strong genetic component, but more research is needed to fully understand the specific genes involved.

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Community Join

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community M34 – On finasteride, unsure about starting minoxidil

in Minoxidil 2 upvotes 1 month ago

A 34-year-old male, already on finasteride, is hesitant to continue minoxidil due to side effects like headaches and concerns about facial bloating and skin aging. Another user shares their experience with minoxidil causing facial bloating but hopes for hair growth benefits.

community Hims Spray 4 month progress so far. I'm pretty happy with the results. I'm 32

in Progress Pictures 205 upvotes 2 years ago

The conclusion of the conversation is that the user, DixonYasz, has been using Hims spray (which contains both finasteride and minoxidil) for 4 months and is happy with the results. They have noticed their thinning spots filling in with color and their scalp being less visible. They also mentioned using a dermaroller once a week.

community Anyone here going the “natural” route?

in Scalp Massage 48 upvotes 3 years ago

People discussing their experiences with natural treatments for hair loss, such as essential oils, deep scalp massages, anti-inflammatory measures, and supplements. Most of the replies suggest that these treatments are not effective and recommend medication such as minoxidil or finasteride instead.

community Can we have a thread that summarizes all treatments options in addition to the big 3 which we have some evidence for, their mechanism of action and whether they can be combined with the big 3(other than dermarolling)?

in Treatment 54 upvotes 7 years ago

The conversation discusses hair loss treatments beyond the commonly known three, focusing on separating effective treatments from myths. Dutasteride and low-dose oral Minoxidil are mentioned as having clinical evidence for increasing hair counts, but with potential side effects.

community Finasteride - discomfort pelvir/urethra

in Finasteride 79 upvotes 5 months ago

Finasteride can cause pelvic or urethral discomfort for some users. Reducing the dose to 0.25 mg on Mondays, Wednesdays, and Fridays is being considered as a potential solution.

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