63 citations
,
September 2009 in “Regenerative Medicine” This study developed a method for expanding human dermal papilla cells in vitro while maintaining their ability to induce hair growth, advancing the potential for follicular cell implantation as a treatment for hair loss.
44 citations
,
January 2011 in “Journal of biotechnology” This study successfully recreated human hair follicles in vitro, which offers a potential advancement in hair regeneration and understanding the effects of drugs on hair follicles.
39 citations
,
April 2012 in “Journal of controlled release” This study found that using a protease-triggered release system enabled effective delivery of a model drug deep within porcine hair follicles, suggesting a new approach for treating skin conditions.
37 citations
,
September 2010 in “Journal of Hospital Infection” Hair follicles in the nose may need better cleaning to prevent Staphylococcus aureus infections.
25 citations
,
March 2014 in “Experimental Dermatology” Leptin helps start the growth phase of hair.
24 citations
,
November 2013 in “Trends in pharmacological sciences” This article describes a potential novel approach to reduce chemotherapy-induced hair loss by enhancing the expression of specific transporters in hair follicles, but reports no clinical results.
21 citations
,
June 2011 in “Investigative Ophthalmology & Visual Science” This article argues that human scalp hair follicles could serve as a surrogate model for studying immune privilege in the human eye, offering a novel approach for ocular IP research.
20 citations
,
February 1977 in “The anatomical record” This study found that excess vitamin A in organ cultures of mouse embryos led to significant changes in epidermis and hair follicles, altering morphogenesis and polysaccharide distribution.
19 citations
,
October 2017 in “The FASEB Journal” This study established an androgen-responsive human organ culture model using hair follicles, demonstrating that women's intermediate facial follicles grow more hair in response to men's higher androgen levels.
14 citations
,
September 2001 in “Archives of Dermatological Research” This study reported that Sonic hedgehog signaling is crucial for hair follicle development, with its expression being significantly induced in normal embryonic hair germs but inhibited in certain experimental models.
12 citations
,
April 2022 in “Frontiers in Cell and Developmental Biology” This study found that stabilizing β-catenin in a specific mouse model led to temporarily increased hair density but ultimately accelerated hair follicle aging and hair thinning.
11 citations
,
January 2018 in “Acta dermato-venereologica” In this study, researchers identified gremilin-2 as a highly specific gene to the dermal sheath cup, suggesting it plays a key role in maintaining its properties.
11 citations
,
July 2017 in “Regenerative Medicine” This study found that the patch assay effectively reconstituted mature hair follicles using culture-expanded human fetal cells and may serve as a method to assess cell trichogenicity.
10 citations
,
May 2020 in “Frontiers in cell and developmental biology” In this study, researchers found that Dicer, but not Tarbp2, plays a crucial role in regulating the growth phase of hair follicles in post-natal mice.
10 citations
,
November 2010 in “Pigment Cell & Melanoma Research” This study found that epidermal melanocytes can regenerate hair follicles, whereas non-cutaneous or dermal melanocytes cannot, suggesting two distinct melanocyte lineages with potential implications for melanocyte-related diseases.
9 citations
,
June 2016 in “Stem cells” In this study, overexpression of secretory phospholipase A2 Group-IIA in transgenic mice led to depletion of hair follicle stem cells and increased differentiation, linked to changes in histone modifications.
8 citations
,
March 2023 in “BMC Research Notes” This pilot study explored a new method using laser-capture microdissection and 16S rRNA gene sequencing to analyze the human scalp hair follicle microbiome more accurately, revealing region-specific variations in microbial diversity and abundance.
8 citations
,
January 2017 in “Stem Cells International” This study found that overexpression of sFRP4 in skin cells reduces Wnt signaling activation, leading to decreased melanocyte differentiation in regenerating hair follicles.
7 citations
,
January 2018 in “Journal of Tissue Viability” This case report describes an 80-year-old patient whose scalp wound healed by secondary intention, with unexpected hair regrowth observed at 180 days, suggesting hair neogenesis is possible even in older adults.
6 citations
,
June 2017 in “Asian journal of beauty & cosmetology” In this study, Rosa multiflora root extracts showed strong antioxidant activity and promoted expression of growth factors IGF1 and PDGFB, suggesting potential use as a natural hair growth agent.
2 citations
,
July 2025 in “Frontiers in Veterinary Science” This review highlights that microRNAs (miRNAs) play crucial roles in hair follicle development and cycling in cashmere goats, detailing recent advances in understanding their regulatory functions and potential applications in improving cashmere fiber quality and diagnosing hair disorders.
1 citations
,
July 2024 in “British Journal of Dermatology” This study found that inhibiting EGFR and MEK in hair follicles may lead to a partial collapse of the immune privilege in the follicles and increased secretion of IL-33.
1 citations
,
January 2024 in “Food Science and Technology Research” In this study, researchers evaluated the hair growth-promoting effects of strawberry water-extract on human follicle dermal papilla cells and found it enhanced cell metabolism, though it did not significantly alter hair growth-related gene expression.
1 citations
,
December 2022 in “Animals” This study found that miR-27a may influence sheep hair follicle stem cell proliferation and apoptosis by targeting PIK3R3, affecting the AKT/MTOR pathway.
1 citations
,
March 2014 in “TURKDERM” This review discusses the fundamental features of hair follicle biology and its clinical importance, but it reports no new clinical results.
1 citations
,
January 2012 in “International journal of trichology” This study found that keratinocytes derived from the germinative epithelium of ovine hair follicles have extensive in vitro growth potential, challenging the idea that these cells are solely transit-amplifying.
August 2026 in “Lasers in Medical Science” This review suggests that hyperspectral and terahertz imaging show promise in non-invasively assessing scalp changes associated with hair loss, but further validation is needed for clinical application.
June 2026 in “Scientific Reports” This study identified hypericin and berberine as compounds that can support hair growth by enhancing oxytocin receptor expression and acting as an oxytocin receptor agonist, respectively, potentially serving as practical alternatives to oxytocin for treating hair-loss diseases.
December 2025 in “Journal of Cell Communication and Signaling” This review discusses the role of vitamin D receptor signaling in hair follicle biology for alopecia treatment and underscores the need for continued research, without presenting new clinical results.
November 2025 in “Journal of Investigative Dermatology” Disrupted cell interactions in hair follicles contribute to hair loss in androgenetic alopecia.