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30-60 / 1000+ resultsresearch The Dermal Papilla and Hair Follicle Regeneration: Engineering Strategies to Improve Dermal Papilla Inductivity
![Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA)](/images/research/a53be6da-54d3-4629-81fc-178cc4c8bb1e/small/11439.jpg)
research Establishment of 3D Spheroid Human Dermal Papilla Cells as an Effective Model for Hair Growth Screening Compounds Compared with the 2D System: An Example of Minoxidil and 3,4,5-Tri-O-caffeoylquinic acid (TCQA)
3D spheroid cultures of human hair follicle cells are better for hair growth research than 2D cultures, and they provide new insights into how hair growth treatments like minoxidil and TCQA work.
![β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair](/images/research/f22ee802-ae0e-43cf-84ca-3528bdd5f498/small/19905.jpg)
research β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair
β-catenin in the dermal papilla is crucial for normal hair growth and repair.
![Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp](/images/research/dd09411b-9ab6-4835-affb-5b8141ad6930/small/21047.jpg)
research Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp
Cells from balding scalps have more androgen receptors than cells from non-balding scalps.
![Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop](/images/research/fea0a7e5-d520-4526-a1b5-119f899e0404/small/19832.jpg)
research Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop
Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.
![Regulation of hair follicle development by exosomes derived from dermal papilla cells](/images/research/7edc8c3d-66c0-4c24-9a80-0a5742e6cd19/small/17922.jpg)
research Regulation of hair follicle development by exosomes derived from dermal papilla cells
Exosomes from dermal papilla cells can help grow hair and might treat hair loss.
![Self-assembly of dermal papilla cells into inductive spheroidal microtissues on poly(ethylene-co-vinyl alcohol) membranes for hair follicle regeneration](/images/research/b0ed04d4-1725-4943-9f3b-709dfa98bf1f/small/2813.jpg)
research Self-assembly of dermal papilla cells into inductive spheroidal microtissues on poly(ethylene-co-vinyl alcohol) membranes for hair follicle regeneration
EVAL membranes help create cell structures that can regrow hair follicles.
![Scalable production of controllable dermal papilla spheroids on PVA surfaces and the effects of spheroid size on hair follicle regeneration](/images/research/001f1984-b690-4f92-a2fb-ff1734df0c7e/small/3247.jpg)
research Scalable production of controllable dermal papilla spheroids on PVA surfaces and the effects of spheroid size on hair follicle regeneration
Larger spheroids improve hair growth, but size doesn't guarantee thicker hair.
![Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia](/images/research/ff11d1f5-b5f9-4123-9a65-381f5071d5bc/small/2474.jpg)
research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia
TGF-β1 from dermal papilla cells suppresses hair growth, and targeting it may help treat androgenetic alopecia.
![Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation](/images/research/4368cc84-cdb2-4927-a426-2d7df4bb30d0/small/29041.jpg)
research Exosomal Micro RNAs Derived from Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation and Differentiation
Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.
![Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo](/images/research/92c8944e-1bf3-4cf1-996d-5b8eccfc6e11/small/19839.jpg)
research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences between Sox2-Positive and -Negative Cells In Vitro and In Vivo
Sox2-positive dermal papilla cells have unique characteristics and contribute more to skin and hair follicle formation than Sox2-negative cells.
![Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair‐inductive capacity of cultured dermal papilla spheres](/images/research/67a67012-e6db-461e-aa8f-bc1ac5ef2ed0/small/4561.jpg)
research Exosomes derived from human dermal papilla cells promote hair growth in cultured human hair follicles and augment the hair‐inductive capacity of cultured dermal papilla spheres
Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.
![Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal–Epidermal Composites](/images/research/8c0e1ac7-c1ab-4463-8e13-0f022f5f38bd/small/12198.jpg)
research Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal–Epidermal Composites
Human skin cells can create new hair follicles when transplanted into mice.
research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factor(s) in Response to Testosterone Unlike Scalp Cells
Beard cells, unlike scalp cells, produce growth factors in response to testosterone, which may explain differences in hair growth.
research Interaction between dermal papilla cells and follicular epithelial cells in vitro: effect of androgen.
Testosterone helps beard and axillary hair cells grow by releasing growth factors from dermal papilla cells.
![Sustained release of dermal papilla-derived extracellular vesicles from injectable microgel promotes hair growth](/images/research/07c13441-25aa-4afa-928e-1b0c398862be/small/22905.jpg)
research Sustained release of dermal papilla-derived extracellular vesicles from injectable microgel promotes hair growth
Injecting a special gel with human protein particles can help hair grow.
![Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia](/images/research/ce010f64-20dc-465e-8395-a42fb29a3036/small/3872.jpg)
research Differential Expression between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia
New genes found linked to balding, may help develop future treatments.
![The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility](/images/research/5c34aa11-d408-496b-90dc-8b78d6bd1b18/small/19922.jpg)
research The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility
Skin cell clumping for hair growth is improved by a protein called fibronectin, which helps cells stick and move better.
![Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells](/images/research/a485ce31-318c-422e-ab8f-02cafe9583be/small/18295.jpg)
research Induction of hair follicle dermal papilla cell properties in human induced pluripotent stem cell-derived multipotent LNGFR(+)THY-1(+) mesenchymal cells
Researchers found a way to create cells from stem cells that act like human cells important for hair growth and could be used for hair regeneration treatments.
![De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle](/images/research/2a9d77a6-e7db-4914-a100-4fa3b7e305aa/small/19888.jpg)
research De Novo Production of Dermal Papilla Cells during the Anagen Phase of the Hair Cycle
New cells are added to the hair's dermal papilla during the active growth phase.
![Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction](/images/research/88ae6482-e75d-4af4-91d0-da937fdf70bc/small/12781.jpg)
research Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction
Combining skin cells with fat-derived stem cells can improve hair growth.
research Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1
Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.
![Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction](/images/research/06eed134-b85f-4446-9f90-558270275415/small/12745.jpg)
research Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelial-mesenchymal interaction
Stress can cause early aging in certain skin cells, leading to problems with hair growth.
![A review of adipocyte lineage cells and dermal papilla cells in hair follicle regeneration](/images/research/bf9a7368-d1aa-4e38-b5bb-d7fb27445fc7/small/3496.jpg)
research A review of adipocyte lineage cells and dermal papilla cells in hair follicle regeneration
Cell-based therapies using dermal papilla cells and adipocyte lineage cells show potential for hair regeneration.
![STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction](/images/research/e46ad177-bb96-4263-a0f8-a66e92063913/small/19600.jpg)
research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction
STAT5 activation is crucial for starting the hair growth phase.
![Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach](/images/research/89fa837c-85fb-4ca8-a9e9-f3de1106a9a5/small/14474.jpg)
research Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach
The document concludes that dermal papilla cells are key for hair growth and could be used in new hair loss treatments.
![Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles](/images/research/8166a9e3-6f74-45d1-a2f7-34b4e1b565ee/small/29290.jpg)
research Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles
Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.
![Microencapsulated human hair dermal papilla cells: a substitute for dermal papilla?](/images/research/935f3bbb-4fc3-4a29-93c8-32a83d5c626e/small/19951.jpg)
research Microencapsulated human hair dermal papilla cells: a substitute for dermal papilla?
Encapsulated human hair cells can substitute for natural hair cells to grow hair.
![Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles](/images/research/9566526f-e07f-47b6-ae4b-7911af4a9ecb/small/18729.jpg)
research Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles
Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.