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The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Odontogenic keratocysts are caused by abnormal Hedgehog signaling and can lead to tooth and bone issues.

Krt15+ cells in the mouse intestine resist radiation and can start tumors.

Miz1 is essential for proper hair structure and growth.

A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.

Reducing Tyrosinase prevents mature color pigment cells from forming in mouse hair.

ACBP is crucial for healthy skin in mice.

Genetic variations greatly affect individual metabolism and can impact health and disease risk.

Higher testosterone levels can increase the risk of certain diseases like type 2 diabetes in women and prostate cancer in men, but can also protect against autoimmune diseases and hair loss. It also affects body fat and bone density.

A protein in plants needs to bind two lipids to help with root hair growth, and this process is similar across different plant species.

VDR regulation varies by tissue and is crucial for its biological functions.

Nagashima-type palmoplantar keratosis in Asians is caused by a SERPINB7 gene mutation.

Testosterone's effects on COVID-19 are unclear and need more research.

Keratosis pilaris is often linked to genetic mutations and causes skin and hair abnormalities, regardless of those mutations.

TGM3 is important for skin and hair structure and may help diagnose cancer.

PTEN helps control the number and health of skin stem cells by working with the protein BMAL1.

Loss of Msx2 function causes eye development issues similar to Peters anomaly.

New treatments for ichthyosis, like protein replacement and gene therapy, show promise and may become standard care.

Sex hormones like estrogen and testosterone may affect COVID-19 severity differently in men and women, potentially influencing prevention and treatment strategies.

KCNQ potassium channels help control the sensitivity of touch receptors in the skin.

Mice without certain skin enzymes have faster hair growth and bigger eye glands.

The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.

Researchers found WNT10A to be a key gene in developing goat hair follicles.

A specific gene variant causes severe skin issues and increases infection risk, requiring careful medical monitoring.

Oxidative stress plays a significant role in alopecia areata, and new treatments may include JAK inhibitors and antioxidants.

Activin A and follistatin control when hair cells develop in mouse ears.

Rapamycin reduces age-related hearing cell loss in mice, but acarbose does not.

Scientists restored fertility in male mice lacking a key fertility gene by using a modified gene.

The same genetic mutation in Sjögren-Larsson syndrome can lead to different levels of severity, suggesting other factors influence the symptoms.

Scientists made a mouse model of a serious skin cancer by changing skin cells with a virus and a specific gene, which is similar to the disease in humans.