57 citations
,
July 2000 in “Toxicology Letters” This study found that the K6/ODC transgenic mouse model is highly sensitive to identifying genotoxic carcinogens, showing 100% concordance with traditional rodent bioassays.
50 citations
,
April 2014 in “Nature Communications” This study analyzed skin from 538 knockout mouse mutants and identified 50 with epidermal phenotypes, providing valuable insights into genetic conditions and systemic effects related to skin abnormalities.
2 citations
,
August 2016 in “Journal of Investigative Dermatology” 70 citations
,
February 2016 in “EMBO reports” This study identified a subtype of itch-sensing neurons in mice, which express Ret and somatostatin, and found that their ablation reduces scratching induced by certain pruritogens.
11 citations
,
May 1995 in “The journal of investigative dermatology/Journal of investigative dermatology” 8 citations
,
September 2011 in “Scanning” This study found that multiphoton microscopy effectively visualizes the microstructure of in vivo mouse skin, offering a clear view of various skin layers and components like corneocytes and collagen fibers.
3 citations
,
June 2002 in “Transgenic Research” This study suggests that inducible transgenic mice showing hair follicle changes similar to telogen effluvium in humans might serve as a useful model for understanding this type of hair loss.
93 citations
,
April 2003 in “Proceedings of the National Academy of Sciences of the United States of America” This study identified an unexpected critical role for the FATP4 protein in skin and hair development in mice, linking it to a potential candidate gene for restrictive dermopathy in humans.
39 citations
,
June 2018 in “Burns” This study found that the spiny mouse can regenerate tissues such as skeletal muscle, dermis, and hair without scarring after full thickness thermal burns, unlike the lab mouse.
This study identified the TALE homeodomain transcription factor Meis2 as a crucial regulator for the maturation and end-organ innervation of certain mechanoreceptors in mice, with its absence leading to altered sensory neuron structure and impaired touch sensitivity.
14 citations
,
February 2018 in “Psychoneuroendocrinology” This study found that male 5α-reductase 2 knockout mice showed deficits in social dominance behaviors and reduced dopamine receptor binding in a brain region related to social ranking.
5 citations
,
February 1981 in “Experientia” In this study, a new hairless gene in the Donryu rat strain was identified, showing skin similarities to human skin tumors with multiple follicular cysts.
24 citations
,
July 1994 in “Journal of Investigative Dermatology”
4 citations
,
April 2018 in “Biotechnology Letters” Human growth factor 20 can boost mouse whisker growth.
5 citations
,
March 2022 in “STAR Protocols” This article presents a protocol for using mouse tail skin to study hair follicle stem cells, enabling visualization of calcium signaling and other cellular features in various conditions but reports no new research data.
5 citations
,
June 2012 in “Journal of Investigative Dermatology” Harris et al. describe a new mouse model for vitiligo, where interfollicular melanocytes are retained and melanocyte-targeting immune responses are simulated, aiding the development of immunomodulatory therapies.
1 citations
,
September 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that stress-induced inactivation of the enzyme Dicer in melanocytes can cause premature hair greying by preventing proper melanocyte placement and melanin transfer in mice, suggesting the Dicer-miR92b-ItgaV pathway as an important link between stress and grey hair.
11 citations
,
March 2014 in “Journal of Investigative Dermatology” In this study, basal cell carcinoma developed in Ptch-deficient mice only after chemical treatment, not skin wounding, suggesting a second unknown event is necessary for tumor formation.
245 citations
,
January 1998 in “Genes & Development” This study found that Hoxc13 mutations in mice cause defects in hair, nail, and tongue structures, with the most noticeable issue being brittle hair leading to alopecia.
32 citations
,
January 2016 in “Development” This study introduced Scd3-Cre mice, which enabled sebocyte-specific manipulation, revealing that sebaceous lipid depletion impaired water repulsion, thermoregulation, and the ocular surface, resembling Meibomian gland dysfunction.
This study details the presence of two types of cysts in rhino mouse skin, with utricles derived from hair canals and deeper cysts from hair root sheath epithelium.
June 2024 in “Georgetown Scientific Research Journal” This study found that intradermal bleomycin injections induced dermal fibrosis in C57BL/6 mice, evidenced by hair follicle obliteration and dermal thickening, though no significant trends in gene expression were observed, indicating the need for further research to understand the link between fibrosis and dyschromia.
36 citations
,
July 1996 in “The journal of investigative dermatology/Journal of investigative dermatology” This research reports a new autosomal recessive mutation in mice, 'lanceolate hair', causing generalized alopecia and hair shaft abnormalities, which may serve as a model for Netherton's syndrome in humans.
In this study, Sox13 was identified as a novel marker for early hair follicle development and differentiation in mice, though it appears to be dispensable for overall epidermal and adnexal development.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that manipulating both gene expression and matrix stiffness in mice can alter hair regeneration after skin wounding, highlighting key factors in regenerative biology.
26 citations
,
April 1996 in “Journal of Investigative Dermatology” 26 citations
,
July 2007 in “Wound Repair and Regeneration” This study found that MRL/MpJ mice heal burn wounds with scar formation, experiencing delayed wound closure and impaired myofibroblast development, which contrasts with quicker contraction in BALB/c mice.
2 citations
,
May 2023 in “Veterinary Pathology” This article outlines methods to study the skin and its molecular traits, focusing on interpretation and techniques applicable to mouse models, including diverse assays and approaches like electron microscopy and large-scale lipid analyses.
179 citations
,
June 2000 in “The American journal of pathology” This study reports that the asebia-2J mutation in mice affects sebaceous gland function and leads to hair follicle destruction, offering a model for human scarring alopecias.
27 citations
,
November 1991 in “Journal of Investigative Dermatology”