Morphological and Functional Analysis on M3R Mediated Sweating in TSC1 Knockout Mouse
August 2019
TLDR Sox13 is a marker for early hair follicle development but not essential for skin and hair growth.
The study investigated the role of the mTOR signaling pathway in sweating dysfunction in TSC patients and model mice. It was found that both TSC patients and TSC model mice exhibited decreased sweating. This was associated with decreased intracellular filaments in the myoepithelial cells of sweat glands. The application of rapamycin gel improved sweating in TSC model mice, suggesting that the TSC-mTOR signaling pathway might be involved in the regulation of sweating.
