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High levels of male hormones in women without tumors are linked to metabolic problems and can be treated with metformin.

Metformin helps improve symptoms and reproductive outcomes in people with polycystic ovary syndrome.

The patient's high testosterone was reduced by a medication that suppresses gonadotropin.

PCOS in teen girls should be managed with lifestyle changes and sometimes medication to improve symptoms and health.

Pediatric endocrinologists should provide early fertility counseling and preservation options to young patients at risk of infertility.

Understanding genes and hormones is crucial for managing male puberty and sex development disorders.

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

Reconstructed skin models are useful for studying how skin processes certain chemicals.

Foreskin keratinocytes and SVK14 cells express certain cytochrome P450 enzymes, unlike hair follicle keratinocytes.

A gene in Sebekia benihana, CYP-sb21, is needed for a specific reaction on the drug Cyclosporine A, which could be important for hair growth without affecting the immune system.

Researchers found two enzymes in Avicennia marina that help produce maslinic acid and corosolic acid, which have medicinal benefits.

Cytochrome P-450 enzymes in the skin help break down various substances and could be targeted to treat skin conditions.

11α-Hydroxyprogesterone is changed into different substances by certain enzymes and may play a role in prostate cancer.

Astilbin can potentially calm overactive immune responses, like in Type 1 Diabetes, by suppressing certain cell activities and reducing inflammation.

Potential new drugs for treating PCOS were identified.

Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.

Photobiomodulation therapy using red and near-infrared light can reduce inflammation and aid in healing various conditions.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Low-level laser therapy, now called photobiomodulation, is recognized for its broad medical applications and scientific backing.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

A cystic fibrosis patient developed Cushing's syndrome from a drug interaction between itraconazole and budesonide, which improved after stopping the medications.

Steroids, particularly estrogens and 5α-reductase inhibitors, affect blood vessel-related hair growth processes in hair follicle cells.

Spironolactone successfully treated hair loss in a 9-year-old girl.

Some herbal medicines can interfere with chemotherapy, affecting treatment and causing side effects.

A cystic fibrosis patient developed Cushing's syndrome from a drug interaction between itraconazole and inhaled budesonide.

Scientists found a new gene in a bacterium that can modify an immunosuppressant drug, potentially helping to treat hair loss.

The authors suggest that 5-α-reductase inhibitors, like dutasteride, are effective in treating frontal fibrosing alopecia and should be the first-line treatment, with other options for severe cases. They also recommend further research on Janus kinase inhibitors.

Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.