Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that most UK women prescribed cyproterone acetate/ethinylestradiol before and after 2013 had conditions aligning with approved indications and prior acne treatment.

This case report describes a 57-year-old woman's virilizing adrenal tumor effectively treated with the antiandrogen cyproterone acetate, which led to symptom reversal and tumor resolution.

This study found that the dehydroepiandrosterone hydroxylating enzyme system in hair follicles is similar to the liver monooxygenase system, sharing characteristics such as inhibition by carbon monoxide and dependency on NADPH.

This study found that astilbin downregulates effector CD4+ T cell activities through the CYP1B1/ROS/PPARγ pathway, suggesting its potential use in treating inflammation.

This study found that human liver dehydroepiandrosterone sulfotransferase (DHEA ST) catalyzes the sulfate conjugation of minoxidil, indicating another pathway contributing to its metabolism in humans.

This study found that scabies was the most common skin condition among children up to 15 years old at a Karachi hospital in 2005.

This study found that hydroxycinnamate derivatives, especially a compound named 10a, effectively inhibited SRD5A1 activity and protein expression in cell assays, suggesting potential for treating androgen-related conditions.

This study found that Cuscuta reflexa extracts promoted hair regrowth and follicular proliferation in cyclophosphamide-induced hair loss in male rats.

This study developed a new method to analyze Cantú syndrome mutations in KATP channels, finding that while Kir6.1 mutations increase sensitivity to potassium channel openers, SUR2B mutations show reduced sensitivity, but both result in marked hyperpolarization compared to wild-type channels under basal conditions.

This article updates a prior work on pharmacophore modeling and highlights the advances in 3D database searching technologies for drug design, without presenting new research findings.

This study synthesized and characterized new 2-hydroxypyrrolidine/piperidine derivatives using FeCl₃·6H₂O as a catalyst, but it reports no biological or clinical results.

This study demonstrated that methylation of the 5-alpha reductase type 2 (5-AR2) promoter is linked to reduced expression of the 5-AR2 protein, possibly explaining resistance to Finasteride in some BPH patients.

This article reviews the discovery and various physiological effects of cyproterone acetate, reporting its established indications for several androgen-driven conditions but providing no new clinical data.

This study found that Cyclosporin A may prolong the anagen phase of hair growth in cultured dermal papilla cells by decreasing TGF-β2 expression, similar to its mechanism in immunosuppression.

This study reviewed reports on interactions between psychotropic drugs and natural beverages, finding that substances like grapefruit juice and St John's wort can significantly affect drug metabolism, emphasizing the need for physician-patient education on drug administration to prevent harmful interactions.

In this study, cyproterone acetate combined with estradiol dramatically improved hirsutism symptoms and significantly reduced plasma testosterone and androstenedione levels in patients over periods of up to three years.

This study synthesized and evaluated hydroxycinnamate derivatives for their ability to inhibit human SRD5A1, finding that three compounds showed significant inhibitory activity and low cytotoxicity. Compound 10a notably reduced SRD5A1 protein expression in cells, suggesting potential for nonsteroidal treatment of androgen-related conditions.

In this study, manipulation of the enzyme 5α-reductase type 2 in human hepatocytes altered lipogenesis, suggesting clinical implications for patients using 5α-reductase inhibitors by affecting glucocorticoid action on hepatic lipid metabolism.

This study found that treatment with cyproterone acetate and estradiol improved emotional well-being and acceptance of being viewed among women with hirsutism, with no significant differences between oral and transdermal estradiol groups.

This review covers the pathophysiology, diagnosis, and treatment of nonclassic congenital adrenal hyperplasia due to P450c21, but it reports no new clinical results.

This study suggests that PF-0998425 is an effective androgen receptor antagonist for sebum control and androgenetic alopecia with rapid metabolism reducing the risk of systemic side effects.

This study reported that the NUDT15 R139C genetic variant was significantly associated with thiopurine-induced leukocytopenia in Japanese inflammatory bowel disease patients, independent of 6-thioguanine nucleotide levels.

This study found that the PON1 192 R allele was associated with an increased risk of psoriasis and altered lipid profiles in patients from Western Mexico.

This study determined that previous reports mistakenly identified different polymorphs of furosemide and finasteride, which are actually identical, due to incomplete data collection in single-crystal X-ray diffraction analysis.

This study found that humulen, a phytoconstituent of Cyperus Rotundus Linn., showed the highest binding affinity in molecular docking with the 5 α reductase enzyme, suggesting potential anti-androgenic effects for hirsutism treatment.

This article reviews the use of cyproterone acetate for conditions like prostate cancer and sexual disorders, highlighting its effects on libido but reporting no new specific trial results.

This study reviewed the current understanding of congenital adrenal hyperplasia from 21-hydroxylase deficiency, highlighting the impact of universal newborn screening in reducing mortality and discussing ongoing treatment challenges and future therapeutic prospects.

This article presents four case reports of men with porphyria cutanea tarda and hepatitis C, highlighting associations with polysubstance abuse, primarily alcohol.

In this study, an LC/MS/MS method was successfully developed to determine finasteride concentrations and study its pharmacokinetics in healthy male Chinese volunteers.

This scoping review identifies various pharmacological agents and five key mechanistic strategies being studied in vivo to mitigate multi-organ toxicity caused by cytarabine, with apraglutide and N-acetylcysteine highlighted as promising candidates for clinical application.