Pharmacological Strategies for Mitigating Cytarabine-Induced Multi-Organ Toxicity: A Scoping Review on Mechanisms, Efficacy and Clinical Implications

    June 2026 in “ Cancers ”
    Ioannis Konstantinidis, Sophia Tsokkou, Kali Makedou … Theodora Papamitsou
    Studysummary This scoping review identifies various pharmacological agents and five key mechanistic strategies being studied in vivo to mitigate multi-organ toxicity caused by cytarabine, with apraglutide and N-acetylcysteine highlighted as promising candidates for clinical application.
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    Research cited in this study 5

    1. Unraveling Translational Insights Into Systemic Multi-Organ Toxicity of Cytosine Arabinoside (Ara-C): A Systematic Review of Preclinical Animal Evidence Current Issues in Molecular Biology · 2025
    2. The Alpha-Lipoic Acid Derivative Sodium Zinc Dihydrolipoylhistidinate Reduces Chemotherapy-Induced Alopecia in a Rat Model: A Pilot Study Surgery today · 2011
    3. The Effect of Active Hexose Correlated Compound in Modulating Cytosine Arabinoside-Induced Hair Loss, and 6-Mercaptopurine- and Methotrexate-Induced Liver Injury in Rodents Cancer epidemiology · 2009
    4. Protection Against Cytosine Arabinoside-Induced Alopecia by Minoxidil in a Rat Animal Model International Journal of Dermatology · 1995
    5. Treatment with ImuVert and N-Acetylcysteine Protects Rats from Cyclophosphamide and Cytarabine-Induced Alopecia Cancer investigation · 1992