Hydroxylation of Dehydroepiandrosterone in Human Scalp Hair Follicles

    June 1979 in “ British Journal of Dermatology ”
    A.J.M. Vermorken, C. M. A. A. Goos, P.Th. Henderson, H. Bloemendal
    TLDR The enzyme system in hair follicles is similar to the liver's and is affected by certain inhibitors.
    The study characterized the dehydroepiandrosterone hydroxylating enzyme system in human scalp hair follicles, finding it in the particulate fraction of the follicle. This enzyme system was inhibited by carbon monoxide and the cytochrome P450 inhibitor metyrapone, and it depended on NADPH. These characteristics showed similarities to the liver monooxygenase system.
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