TLDR The enzyme system in hair follicles is similar to the liver's and is affected by certain inhibitors.
The study characterized the dehydroepiandrosterone hydroxylating enzyme system in human scalp hair follicles, finding it in the particulate fraction of the follicle. This enzyme system was inhibited by carbon monoxide and the cytochrome P450 inhibitor metyrapone, and it depended on NADPH. These characteristics showed similarities to the liver monooxygenase system.
28 citations
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March 1973 in “The Journal of Clinical Endocrinology & Metabolism” Altered DHEA metabolism in hair follicles may be linked to hair loss in balding men.
31 citations
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October 1971 in “Steroids” Human beard hair follicles change testosterone into other related hormones, but don't much change androstenedione into testosterone.
November 2023 in “British Journal of Dermatology” Different people with severe hair loss respond to baricitinib treatment at different times, with some showing improvement early, some gradually, and others later.
April 2022 in “Journal of Cosmetic Dermatology” Trimax-360 Serum, when used for 98 days, safely and effectively improves hair growth, thickness, and density without any side effects.
34 citations
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August 2003 in “Clinical and Experimental Dermatology” Pregnant women's hair gets thicker.
26 citations
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October 1999 in “Archives of Dermatology” Curly hair in certain scalp areas can be an early sign of hair loss.
