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Glossary Metyrapone

Metyrapone is a medication primarily used to test adrenal function by inhibiting the enzyme 11β-hydroxylase, which is involved in cortisol synthesis. Its relevance to hair loss lies in its potential effects on hormonal balance, particularly cortisol levels, which can influence hair growth and loss. Elevated cortisol levels are often associated with stress-related hair loss conditions, making metyrapone a point of interest in understanding the hormonal pathways that affect hair biology. Key distinguishing characteristics include its role in diagnosing adrenal insufficiency and its impact on steroid metabolism.

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research METYRAPONE AS A BRIDGING THERAPY IN FLORID CUSHING’S DISEASE PATIENT PRIOR TO PITUITARY ADENOMECTOMY

July 2023 in “Journal of the ASEAN Federation of Endocrine Societies”

This case study details the successful use of metyrapone to manage severe Cushing’s disease symptoms and stabilize a patient’s biochemical parameters before she underwent pituitary surgery.

research Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction

15 citations , June 2014 in “Behavioural Brain Research”

Neurosteroids may help metyrapone reduce cocaine addiction.

Persistent Escalation of Alcohol Consumption by Mice Exposed to Brief Episodes of Social Defeat Stress: Suppression by CRF-R1 Antagonism

research Persistent escalation of alcohol consumption by mice exposed to brief episodes of social defeat stress: suppression by CRF-R1 antagonism

38 citations , April 2018 in “Psychopharmacology/Psychopharmacologia”

In this study, socially defeated mice showed increased alcohol consumption, and CRF-R1 antagonism selectively reduced drinking in these mice, suggesting a potential treatment target for stress-related alcohol use disorders.

research 11β-Hydroxylase inhibitors protect against seizures in mice by increasing endogenous neurosteroid synthesis

18 citations , April 2011 in “Neuropharmacology”

This study found that metyrapone and etomidate provide dose-dependent anticonvulsant effects against seizures, with delayed effectiveness linked to increased neurosteroid levels.

research Hydroxylation of dehydroepiandrosterone in human scalp hair folhcles

11 citations , June 1979 in “British Journal of Dermatology”

This study found that the dehydroepiandrosterone hydroxylating enzyme system in hair follicles is similar to the liver monooxygenase system, sharing characteristics such as inhibition by carbon monoxide and dependency on NADPH.

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learn Pyrilutamide

highly targeted anti-androgen that might have minimal systemic effects

learn Setipiprant

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