37 citations
,
August 2000 in “Journal of Cutaneous Pathology” This study found that keratin immunohistochemistry suggests neoplastic cells in eccrine and apocrine poromas are closely related to dermal sweat duct cells, but cannot differentiate these poromas based solely on keratin patterns.
21 citations
,
May 2014 in “Toxicological Sciences” This study found that skin exposure to toluene diisocyanate in mice creates immune-recognition reservoirs in the skin's stratum corneum and hair follicles, potentially leading to sensitization and allergic reactions.
March 2026 in “Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials” This study investigated the mechanical response of the human hair cuticle to strain and found that cuticular deformation directly corresponded with fiber elongation, revealing significant molecular-level changes in disulfide crosslinks but maintained structural stability, highlighting the role of the cuticle in stress resistance.
40 citations
,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the S100A3 gene is exclusively expressed in hair follicle cells differentiating into hair shaft components in mice, suggesting its important role in hair formation.
34 citations
,
December 1984 in “Journal of Cutaneous Pathology” This study observed that the thinning and structural abnormalities in monilethrix-affected hair occur at the internodes due to possible periodic dysfunction of the hair matrix, particularly in the cortex.
11 citations
,
January 1981 in “Cells Tissues Organs” This article describes the structure and components of hair cuticle cells and their intercellular junctions but reports no new clinical results.
6 citations
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January 2005 in “Han-guk hyeonmigyeong hakoeji/Applied microscopy” This study found that the 16th-century mummified hair from a female mummy in Paju was remarkably well-preserved, with the hair's ultrastructural features maintained likely due to a calcium-rich surface coat.
1 citations
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August 2015 in “PubMed” This study discovered previously unknown structures in human hair shafts that may stabilize hair structurally and physicochemically.
April 2026 in “Microscopy Research and Technique” In this study, researchers found that a high-cost hair restoration product containing coconut oil and glycerol effectively restored the structural integrity of chemically processed hair, particularly in samples that were significantly damaged by bleaching and color treatments.
17 citations
,
June 2012 in “Journal of experimental zoology. Part B, Molecular and developmental evolution” This review explores theories on the evolution of hair from synapsid scales and glands, proposing mechanisms supported by comparative studies, but reports no new experimental findings.
7 citations
,
January 2001 in “Comprehensive series in photosciences” This study found that UV stabilizers must diffuse uniformly and in high uptake levels throughout hair fibers during humidification cycles to effectively prevent photo-oxidative degradation.
3 citations
,
September 2005 in “International Journal of Cosmetic Science” This study found that monounsaturated oils like olive oil penetrate hair fibers effectively, whereas polyunsaturated oils typically do not penetrate beyond the cuticle.
4 citations
,
January 2017 in “Biological & pharmaceutical bulletin” This study found that inhibiting arachidonate 12-lipoxygenase (ALOX12) may enhance hair cuticle maturation by increasing S100A3 protein citrullination and promoting cuticular differentiation in isolated human hair follicles.
January 2017 in “대한미용학회지” This study observed that hair follicle cuticular cells undergoing keratinization were significantly thicker than those in a normal hair shaft, due to incomplete loss of cytosol.
May 1988 in “Journal of Forensic Sciences” This study reports an improved method for determining blood type from human hair using immunohistochemistry.
7 citations
,
May 1988 in “International Journal of Dermatology” This case report describes an 18-year-old man with pili annulati, characterized by a "shagreened" appearance of the hair shaft with alternate bright and dark bands and wide holes throughout the cortex.
In this study, patients with systemic lupus erythematosus and generalized non-scarring alopecia exhibited hair loss similar to telogen effluvium, with significant changes observed in the cuticle of telogen hairs.
September 1998 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” The document concludes that individualized treatments for hair issues are effective, certain hair changes can indicate neurocutaneous diseases, specific lotions improve skin health, laser hair removal works but needs more study on long-term effects, men's cosmetics are diverse, peeling is effective but can have side effects, and facial pigmentation is often due to overactive skin cells.
29 citations
,
February 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that Merkel cell clusters require Frizzled6 signaling for their polarity information, while other hair follicle-associated structures align their orientation based on the hair follicle itself.
33 citations
,
June 2017 in “Developmental Biology” This study found that local refinement of hair follicles into higher order patterns can occur without the core planar cell polarity system, but global alignment with body axes requires its function throughout development and regeneration.
23 citations
,
June 2015 in “Journal of Tissue Engineering and Regenerative Medicine” This study demonstrated that a 3D air–liquid culture system using Wnt-CM-treated cells can induce hair regeneration in nude mice and may facilitate large-scale preparation for hair loss treatment.
63 citations
,
January 1992 in “Experimental Neurology” This study in neonatal chicks reported that intense sound exposure severely impaired auditory function, but function returned to near normal within 3 days, primarily due to non-hair-cell mechanisms.
41 citations
,
December 2018 in “Experimental Dermatology” This review explores recent findings on the roles of melanocyte and melanocyte stem cells in the hair follicle, highlighting their importance for skin health and potential applications in regenerative medicine, but reports no new clinical results.
7 citations
,
July 2019 in “International Journal of Molecular Sciences” This study found that PGA-4HGF nanoparticles enhanced hair growth in mice more effectively than 4HGF alone by increasing anagen phase duration and dermal papilla cell proliferation.
This Ph.D. project aims to evaluate the self-assembling potential of hair keratin extracts and study the cellular response to both crude and purified keratins, highlighting their potential applications from biomedical to water remediation.
1 citations
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February 2025 in “Scientific Reports” In this study, researchers found that CD4 is expressed on murine K5+ keratinocytes, and its expression is crucial for maintaining epidermal stem cell balance and wound repair capacity, particularly during aging.
April 2025 in “Journal of the Association for Research in Otolaryngology” In this study, researchers observed that inhibiting myosin light chain kinase in hair cells reduced stiffness and oscillation in bullfrog hair bundles and increased hearing thresholds in mice.
41 citations
,
October 2000 in “Dermatologic clinics” This paper reviews hair structure and damage from grooming and cosmetic exposure but reports no new clinical findings; it suggests collaboration between dermatologists and cosmetic chemists to improve hair care products.
January 1991 in “Journal of Society of Cosmetic Chemists of Japan” In this study, researchers found that specific enzyme activities in young females' hair follicles were correlated with changes in hair shaft structure and properties, and permanent waving was associated with chemical changes that suggest hair damage.
June 2025 in “Rapid Communications in Mass Spectrometry” In this study, researchers developed a simplified and reliable method to prepare human hair shaft samples, achieving over 75% protein extraction efficiency and improved keratin sequence coverage, with the approach showing high reproducibility across different labs and operators.