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Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.

Small molecule drugs show promise for advancing regenerative medicine but still face development challenges.

A new 3D culture system helps grow and study mouse skin stem cells for a long time.

Overexpression of sPLA2-IIA in mouse skin reduces hair stem cells and increases cell differentiation through JNK/c-Jun pathway activation.

Epidermal stem cells have various roles in skin beyond just maintenance, including forming specialized structures and aiding in skin repair and regeneration.

PRC2 is essential for maintaining intestinal cell balance and aiding regeneration after damage.

The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.

Keratin proteins are essential for keeping the cells in the human colon healthy and stable.

High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.

Different types of stem cells and their environments are key to skin repair and maintenance.

Targeting colon cancer stem cells might lead to better treatment results.

Nrf-2-modified stem cells from hair follicles significantly improve ulcerative colitis in rats.

The study showed that hair follicle stem cells can maintain and organize themselves in a lab setting, keeping their ability to renew and form hair and skin.

Understanding how epigenetic regulation affects stem cells is key to cancer insights and new treatments.

The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.

Organoid technology is advancing and entering commercial use, with applications in disease modeling, drug development, and personalized medicine.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Scientists created a functional 3D skin system from stem cells that can be transplanted into wounds.

Hair follicle samples effectively show how well the drug MK-0752 targets and engages with the Notch pathway.

Metabolism plays a key role in determining stem cell fate.

Eating fewer calories improves the ability of stem cells to repair and renew the body in various tissues.

Researchers created rat liver stem cells that could help repair liver failure in rats and may be useful for studying human liver diseases.

Some stem cells in the body rarely divide, which could help create better treatments for diseases and aging.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

Mesenchymal stem cells could help treat radiation-induced bladder damage but more research is needed to overcome current limitations.

Certain mature cells in mouse lungs can turn back into stem cells to aid in tissue repair.

Small molecule IM boosts hair growth by changing stem cell metabolism.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.