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120-150 / 1000+ resultsresearch Characterization of a 300 kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain
The research identified six functional hair keratin genes and four pseudogenes, providing insights into hair formation and gene organization.
research Proteomic tools for the investigation of human hair structural proteins and evidence of weakness sites on hair keratin coil segments
This study used proteomic techniques to analyze human hair proteins, revealing keratin heterogeneity and identifying posttranslational modifications, such as cysteine trioxidation and methylation.
research The structure of the “amorphous” matrix of keratins
This study suggests that human keratin fiber matrix has a well-defined nano-scale grainy structure rather than being amorphous, with grain size influenced by chemical treatments, temperature, humidity, and follicle-level factors.
research Ossifying pilomatrixoma with marrow formation of the left cheek region – Case report with review of literature
This case report describes an ossifying pilomatrixoma found in a 15-year-old girl, confirmed via histopathological examination after imaging indicated a subcutaneous mass on her cheek.
research Restricted effects of androgens on glucocorticoid signaling in the mouse prefrontal cortex and midbrain
This study found that androgen impacted glucocorticoid signaling in the mouse brain only in the prefrontal cortex and substantia nigra, suggesting limited interaction between these hormones at high corticosterone levels.
research Pilomatricoma in the Infraorbital Region
In this study, pilomatricoma, a benign skin tumor from hair follicle matrix cells, is highlighted as an important consideration when diagnosing painless, firm subcutaneous nodules, with accurate diagnosis relying on histopathological examination.
research Pilomatricoma in the infraorbital region
This case study reports on a rare benign skin tumor known as Pilomatricoma in the lower left orbital region of a 32-year-old male, highlighting its characteristic histopathological features and emphasizing the importance of surgical excision for successful treatment and minimal recurrence risk.
research A study of phenotypic correlation with the genotypic status of HTM regions of KRTHB6 and KRTHB1 genes in monilethrix families of Indian origin
This study identified a mutation in the KRTHB6 gene in two monilethrix families of Indian origin, linking specific genetic variations to different severities of hair defects within the families.
research Single nucleotide polymorphisms in the KRT82 promoter region modulate irregular thickening and patchiness in the dorsal skin of New Zealand rabbits
This study analyzed the genetics of the patchiness phenotype in New Zealand rabbits and found that the gene KRT82, with identified SNPs in its promoter, may serve as a potential biomarker for breeding these rabbits.
research Pregnancy's lasting imprint: Late pregnancy allopregnanolone alters rat fear recall and medial prefrontal cortex activity
In this study, researchers observed that reproductive experience in female rats altered fear memory and medial prefrontal cortex (mPFC) activity, with pregnant and parous rats showing impaired fear recall compared to nulliparous controls, highlighting the influence of pregnancy-related neurosteroids on cognitive function and brain activity.
research Detection of circular RNA expression and related quantitative trait loci in the human dorsolateral prefrontal cortex
This study identified genetic, biological, and technical factors that influence circRNA expression in the human brain, connecting these factors to potential genetic risk for diseases like schizophrenia and type II diabetes.
research A clinico-epidemiological study of scalp hair loss in children (0–18 years) in Kota Region, South-East Rajasthan
This study found that tinea capitis was the most common cause of scalp hair loss in children, affecting over half of cases, followed by alopecia areata, seborrheic dermatitis, and other conditions.
research Acid phosphatase distribution in the wool follicle. III. Fate of organelles in keratinized cells
This study identified the presence of recognizable organelles, such as lysosomes and mitochondria, in both the keratinized fiber and the hardened inner root sheath of the Romney wool follicle.
research Strain and Strain Recovery of Human Hair from the Nano- to the Macroscale
This study found that human hair exhibits significant deformation in its intermediate filaments under strain, with recovery taking about 1000 minutes, suggesting a self-healing period post-mechanical stress. Additionally, cuticle scales deform much less than the cortex, and the Poisson ratio aligns with soft matter properties.
research Effects of different concentrations of androgens on KAP24.1 gene expression in Hetian sheep and Karakul sheep
In this study, researchers successfully cloned the KAP24.1 gene from sheep to analyze its expression in skin and hair follicles, finding that Mountain-type Hetian sheep showed the highest levels of expression and that androgen concentration significantly influenced KAP24.1 protein expression.
research Dlx3 is a crucial regulator of hair follicle differentiation and cycling
This research found that Dlx3 plays a central role in hair formation and regeneration, with its absence leading to alopecia through disrupted differentiation and signaling pathways.
research Sequence and Expression of Murine Type I Hair Keratins mHa2 and mHa3
mHa2 and mHa3 keratins have different structures and roles in mouse hair and tongue tissues.
research Structure and site of expression of a murine type II hair keratin
This study identified and characterized a murine type II hair keratin, demonstrating its presence in specific cells of hair and tongue tissues.
research Extractable substances from human hair: a discussion about the origin of the holes
This study describes the presence of holes in hair fibers, absent in hair follicles, likely forming from daily care actions and removal of extractable substances.
research Pili Annulati
This case report describes an 18-year-old man with pili annulati, characterized by a "shagreened" appearance of the hair shaft with alternate bright and dark bands and wide holes throughout the cortex.
research Fully functional hair follicle organ regeneration using organ-inductive potential stem cells with an accessory mesenchymal cell population in an in vitro culture system
This study identifies a specific cell population, PDGFRα+/Sca1+/CD34+ mesenchymal cells, which play a crucial role in regenerating hair follicles by promoting the downgrowth phase of the hair cycle, offering insights into organ morphogenesis and stem cell niches essential for adult hair regeneration.
research Anti-Aging Medicine for Hair
This article discusses the biology of cosmetic aging and the chemical pathways involved, emphasizing research advancements that aid clinicians in rejuvenating skin and increasing scalp hair density, but it provides no new results.
research Carriers of 21-Hydroxylase Deficiency Are Not at Increased Risk for Hyperandrogenism*
This study concluded that heterozygosity for CYP21 mutations is associated with higher mean and free testosterone levels in women but does not significantly increase their risk of developing clinically evident hyperandrogenism.
research Novel Type I Hair Keratins K39 and K40 Are the Last to be Expressed in Differentiation of the Hair: Completion of the Human Hair Keratin Catalog
K39 and K40 are the last keratins expressed in hair development, completing the hair keratin catalog.
research Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation
This study found that transcription factors HOXC13, LEF1, and FOXN1 repress DSG4 transcription, with the Notch pathway possibly involved in maintaining DSG4 expression in hair follicles.
research Discrete Nanoscale Distribution of Hair Lipids Fails to Provide Humidity Resistance
This study observed that lipids in human hair accumulate in specific areas and do not significantly impact water permeability, highlighting the utility of AFMIR for studying complex biomaterials.
research Ultrastructural Localization of S100A3, a Cysteine-rich, Calcium Binding Protein, in Human Scalp Hair Shafts Revealed by Rapid-freezing Immunocytochemistry
In this study, the researchers identified the specific subcellular localization of the protein S100A3 in the endocuticle and cortex of human hair shafts.
research Keratins: the hair shaft's backbone revealed
This report expands the known genetic mutations linked to monilethrix by identifying new patients with KRT83 mutations, confirming its role as a causative gene for this hair disorder.
research Complementary evolution of coding and noncoding sequence underlies mammalian hairlessness
This study found that specific genetic changes in both coding and noncoding regions may have independently driven the evolution of hairlessness in various mammalian species through accelerated evolution.