Single Nucleotide Polymorphisms in the KRT82 Promoter Region Modulate Irregular Thickening and Patchiness in the Dorsal Skin of New Zealand Rabbits

May 2024 in “ BMC Genomics ”

Bohao Zhao, Jiawei Cai, Xiyu Zhang, Jiali Li, Zhiyuan Bao, Yang Chen, Xinsheng Wu

KRT82 single nucleotide polymorphisms SNPs dorsal skin differentially expressed genes RNA-sequencing

Studysummary This study analyzed the genetics of the patchiness phenotype in New Zealand rabbits and found that the gene KRT82, with identified SNPs in its promoter, may serve as a potential biomarker for breeding these rabbits.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study explores the genetic basis of irregular skin patchiness and thickening in New Zealand rabbits, focusing on the KRT82 gene. Researchers identified 592 differentially expressed genes, with KRT82 showing a significant correlation with hair follicle-related parameters. Four single nucleotide polymorphisms (SNPs) were found in the KRT82 promoter region, potentially influencing its expression and contributing to the patchiness phenotype. The study suggests that KRT82 could serve as a biomarker for breeding experimental rabbits and provides insights into the molecular mechanisms of skin phenotypes, aiding in the evaluation of skin irritation tests.

View this study on bmcgenomics.biomedcentral.com →

Discuss this study in the Community →

Research cited in this study

21 / 21 results

research A Homozygous Missense Mutation in the Fibroblast Growth Factor 5 Gene Is Associated with the Long-Hair Trait in Angora Rabbits

5 citations , June 2023 in “BMC genomics”

This study found that a specific genetic mutation in the Fgf5 gene may contribute to the long-hair trait in Angora rabbits by reducing the binding capacity of the FGF5 protein.

research Hair Follicle Transcriptome Analysis Reveals Genes Regulating Wool Fiber Diameter in Angora Rabbits

3 citations , March 2023 in “Biology”

This study identified 2574 differentially expressed genes in the hair follicles of Wan strain Angora rabbits, suggesting that these genes may influence wool fiber diameter and quality.

research Characterization and Functional Analysis of the WIF1 Gene and Its Role in Hair Follicle Growth and Development of the Angora Rabbit

2 citations , September 2022 in “World Rabbit Science”

This study found that the WIF1 gene may play a crucial role in hair follicle growth and development in Angora rabbits by regulating specific genes and proteins.

research Whole Exome Sequencing in Alopecia Areata Identifies Rare Variants in KRT82

9 citations , February 2022 in “Nature communications”

This study identified KRT82 as a significant Alopecia Areata risk gene, finding that rare damaging variants are linked to elevated immune cell infiltration around hair follicles in affected individuals.

research Non-Thermal Atmospheric Pressure Plasma Activates Wnt/β-Catenin Signaling in Dermal Papilla Cells

24 citations , August 2021 in “Scientific Reports”

This study found that non-thermal atmospheric pressure plasma may stimulate hair growth through activation of the Wnt/β-catenin signaling pathway, suggesting it could be a potential non-pharmacological treatment for alopecia.

research Analyses of Histological and Transcriptome Differences in the Skin of Short-Hair and Long-Hair Rabbits

59 citations , February 2019 in “BMC Genomics”

In this study, transcriptome analysis suggested that lipid metabolism and apoptosis may be key factors influencing hair length differences between short-hair and long-hair rabbits.

research Gene Expression Profiling Analysis Reveals Fur Development in Rex Rabbits (Oryctolagus Cuniculus)

23 citations , August 2017 in “Genome”

This study identified several genes and signaling pathways, such as Wnt and MAPK, involved in fur development in Chinchilla rex rabbits, providing insights into skin and hair follicle growth.

Morphological Analysis of Patchy Thickening and Reddish Discoloration of Active Hair Growth Areas in the Skin of New Zealand White Rabbits

research Morphological Analysis of Patchy Thickening and Reddish Discoloration of Active Hair Growth Areas in the Skin of New Zealand White Rabbits

6 citations , January 2017 in “Journal of toxicologic pathology”

This study suggests that the patchy thickening and reddish discoloration in rabbit skin during the hair cycle may be due to large anagen-phase hair follicles compressing the dermis and increased blood vessels causing redness.

research Differential Gene Expression Profiles in Fetal Skin of Rex Rabbits with Different Wool Density

4 citations , September 2016 in “World Rabbit Science”

This study observed that gene expression differences in Rex rabbits with varying wool densities suggest the involvement of specific genes and signaling pathways, including Shh and Eph, in hair follicle development.

research Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease

1 citations , February 2016 in “Cell Transplantation”

In this study, researchers found that hair follicles and dermal fibroblasts, including dermal papilla cells, supported sustained hair growth in transplanted murine models, with RNA-seq analysis revealing active signaling pathways and gene expression patterns.

research Expression Of Sfrp2 Is Increased In Catagen Of Hair Follicles And Inhibits Keratinocyte Proliferation

25 citations , January 2014 in “Annals of Dermatology”

Sfrp2 increases during hair follicle catagen phase and slows keratinocyte growth.

research Annotation of Sheep Keratin Intermediate Filament Genes and Their Patterns of Expression

83 citations , May 2011 in “Experimental Dermatology”

In this study, researchers identified nine new sheep keratin genes, highlighting species-specific differences in the expression and compartmentalization of wool-related keratin genes compared to humans.

research Diagnostic Exercise: Severe Bilaterally Symmetrical Alopecia in a Horse

7 citations , January 2011 in “Veterinary Pathology”

In this case report, a 9-year-old horse was diagnosed with alopecia areata contributing to Malassezia dermatitis, involving lymphocyte infiltration and symptoms consistent with yeast presence.

research Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair

314 citations , April 2010 in “Developmental Cell”

This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.

research Expression Patterns of Keratin Intermediate Filament and Keratin Associated Protein Genes in Wool Follicles

95 citations , March 2009 in “Differentiation”

Gene expression in wool follicles changes with growth cycles, offering insights into wool and human hair growth.

research Alopecia Areata in a Rhesus Monkey (Macaca Mulatta)

16 citations , April 2007 in “Journal of Medical Primatology”

This study reports that a 14-year-old female rhesus monkey with alopecia universalis was found to have a T-cell-mediated autoimmune disease similar to human alopecia areata universalis.

research The Proteomics of Keratin Proteins

62 citations , August 2006 in “Journal of Chromatography B”

This article reviews the challenges in studying keratin proteins and emphasizes the potential of modern proteomic techniques to advance their research, but it reports no new findings.

research Comparison of Alopecia Areata in Human and Nonhuman Mammalian Species

71 citations , January 1998 in “Pathobiology”

This review discusses the use of animal models to study alopecia areata and reports no new experimental results, emphasizing the potential for these models to explore the disease's genetics and treatment.

research Expression of the Bcl-2 Proto-Oncogene in the Cycling Adult Mouse Hair Follicle

122 citations , July 1994 in “Journal of Investigative Dermatology”

research Alopecia Areata in Aging C3H/HeJ Mice

178 citations , June 1994 in “Journal of Investigative Dermatology”

This study found that a non-scarring alopecia in C3H/HeJ mice resembles human alopecia areata and may serve as a valuable model for studying specific subtypes of the human condition.

research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations , February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study concluded that epidermal growth factor may induce a 'catagen-like' phase in human hair follicles by disrupting normal cellular proliferation and migration patterns.