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Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

Targeted cancer therapies often cause serious skin problems that need careful management.

Regenerated fully functional hair follicles using stem cells, with potential for hair regrowth therapy.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.

Stem cell self-renewal is complex and needs more research for full understanding.

Microneedles improve drug delivery in various body parts, are safe and painless, and show promise in cosmetology, vaccination, insulin delivery, and other medical applications.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Modulating BMP activity changes the number, size, shape, and type of ectodermal organs.

Nanoparticles can improve skin drug delivery but have challenges like toxicity and stability that need more research.

The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.

The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.

Survivors of Stevens-Johnson syndrome/toxic epidermal necrolysis need ongoing care for various long-term health problems.

Laminin-511 is crucial for early hair growth and maintaining important hair development signals.

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

Cholesterol sulfate buildup due to a genetic mutation disrupts the skin barrier, leading to the scaling skin seen in X-linked ichthyosis.

Mutant mice help researchers understand hair growth and related genetic factors.

The skin protects the body and is constantly renewed by stem cells; disruptions can lead to cancer.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

PDRN helps repair tissue and improve wound healing with a high safety profile.

Mesenchymal stem cells show potential for skin healing and anti-aging, but more research is needed for safe use, especially regarding stem cells from induced pluripotent sources.

Costunolide may have multiple health benefits, including promoting hair growth and protecting against cancer and diabetes, but more research is needed.

S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.

Treatment with plasma rich in growth factors improved hair density and thickness for hair loss patients.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

Certain groups may need vitamin supplements to improve hair health and prevent other health problems.

The study identified and characterized new keratin genes linked to hair follicles and epithelial tissues.