57 citations
,
June 2021 in “Polymers” This review discusses photothermal agent hybrids in hydrogels for antibacterial action, angiogenesis, and osteogenesis in tissue engineering, but reports no new experimental findings.
57 citations
,
March 2019 in “Immunity” This review discusses the roles of immune responses and cells in skin health and disease, emphasizing recent insights into their mechanisms and potential therapeutic applications, but presents no new experimental results.
55 citations
,
July 1999 in “Clinics in Sports Medicine” This review discusses recent data on the use of anabolic-androgenic steroids and other steroid compounds and reports no new clinical results.
53 citations
,
April 2021 in “Cell Host & Microbe” This study found that skin microbiota, particularly in wild-type mice, promotes wound-induced hair follicle neogenesis and wound healing, highlighting the potential downsides of routine antibiotic use on skin regeneration.
51 citations
,
June 2016 in “Journal of the European Academy of Dermatology and Venereology” In this study, tofacitinib treatment was associated with significant hair regrowth in two patients with alopecia universalis over eight months, with minimal adverse effects reported.
51 citations
,
October 2002 in “British Journal of Dermatology” Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.
48 citations
,
July 2008 in “Acta Biochimica et Biophysica Sinica” This review discusses the roles and mechanisms of Wnt signaling in embryonic and adult stem cells and its association with cancers, and reports no new experimental findings.
47 citations
,
December 2019 in “Frontiers in immunology” This study identified a novel G207E STING mutation associated with severe inflammatory symptoms and suggested that common polymorphisms in TMEM173 and IFIH1 may modify the phenotype in affected individuals.
47 citations
,
August 2000 in “Endocrine Reviews” This review discusses idiopathic hirsutism, potential underlying mechanisms, and various therapeutic approaches without providing new clinical results, and emphasizes the need for further research on well-defined patient groups.
46 citations
,
November 1997 in “Journal of Neural Transmission” Seborrhea in Parkinson's disease may be linked to hormones, not autonomic impairment.
45 citations
,
February 2018 in “Journal of basic and clinical physiology and pharmacology/Journal of basic & clinical physiology & pharmacology” This review summarizes the ethno-medicinal uses, phytochemical constituents, and biological activities of Acorus calamus, highlighting its potential therapeutic benefits and the importance of further scientific work on this plant.
42 citations
,
November 2002 in “The American journal of pathology” This study observed that nuclear β-catenin expression in non-small-cell lung carcinomas correlates with increased proliferation and loss of key cell-cycle checkpoints, suggesting an oncogenic advantage.
41 citations
,
June 2016 in “Reviews in endocrine and metabolic disorders” This review discusses the role of hormonal dysregulation and metabolic syndrome in hidradenitis suppurativa and reports no new clinical results.
40 citations
,
July 2015 in “Journal of Cellular Biochemistry” This study found that cysteine supplementation significantly increases keratin expression in human keratinocytes, and counteracts the negative impact of iron deficiency on keratin production by enhancing iron availability for cellular processes.
39 citations
,
January 2019 in “Cells” This review discusses the molecular mechanisms of Hutchinson-Gilford progeria syndrome and evaluates current research trends, available mouse models, and prospects for developing therapies, but reports no new clinical findings.
38 citations
,
September 2021 in “Signal Transduction and Targeted Therapy” This review discusses genetic factors contributing to susceptibility and outcomes in COVID-19, including ACE, ACE2, TMPRSS2 variants, HLA genotype, and ABO blood group, but reports no new experimental results.
38 citations
,
April 2016 in “Experimental Dermatology” This review discusses immunohistological and immunofluorescent methods for studying the human hair follicle cell cycle, reporting no new results, and suggests its potential for advancing cell cycle research.
38 citations
,
October 1996 in “Dermatologic Clinics” This review discusses inflammatory and medication-related skin conditions associated with kidney disease and emphasizes the importance of timely referral to nephrology, reporting no new clinical results.
38 citations
,
January 2011 in “Endocrine Journal” This study found that serum vaspin levels were elevated in women with polycystic ovary syndrome compared to controls, but treatment with metformin or weight loss did not significantly change these levels.
37 citations
,
August 2014 in “Journal of experimental botany” This study identified the AtPRPL1 gene in Arabidopsis thaliana as being involved in cell elongation processes, despite unclear changes in cell wall composition from its altered expression.
34 citations
,
January 2005 in “Journal of the American Veterinary Medical Association” This study found that cyclosporine A treatment at 5 mg/kg/day may reduce inflammation and promote gland regeneration in dogs with sebaceous adenitis, though symptoms returned when treatment stopped.
33 citations
,
January 2018 in “The International Journal of Developmental Biology” This review discusses the dual role of cellular senescence in ageing and tissue repair and suggests potential therapeutic applications, with no new experimental results reported.
32 citations
,
November 1996 in “International Journal of Dermatology” This review discusses the use of antiandrogen therapy in dermatology, covering treatments for conditions like acne, hirsutism, and androgenic alopecia but reports no new clinical findings.
31 citations
,
February 2014 in “Inflammation Research” This study found that reduced expression of CD200R1 on monocyte-derived macrophages in rheumatoid arthritis patients was significantly associated with higher disease severity and an imbalance in Th17/Treg cells.
28 citations
,
August 2000 in “Current Opinion in Chemical Biology” This article reviews current osteoporosis treatments, focusing on the potential of selective androgen receptor modulators and other agents to enhance bone formation, but provides no new clinical data.
27 citations
,
June 2023 in “Nature” In this study using genetic mouse models, researchers discovered that senescent melanocytes in nevi secrete osteopontin, which activates hair stem cells, enhancing hair growth; this process is mirrored in human hairy nevi, suggesting a potential therapeutic target for regenerative disorders.
27 citations
,
December 2013 in “Endocrinology” This study established a mouse model for Cushing's syndrome due to a specific Crh mutation, which may help explore the effects of glucocorticoid excess and evaluate treatments for corticosteroid-induced osteoporosis.
27 citations
,
May 2008 in “Neuroscience” This study found that altering neonatal neurosteroid levels affected anxiety and aversive learning in adult rats, possibly through changes in hippocampal GABAergic functions.
27 citations
,
December 2015 in “Mayo Clinic Proceedings” This review presents an evidence-based algorithm for managing hidradenitis suppurativa in primary care, highlighting the need for more research on treatment effectiveness and the disease's pathogenesis.
27 citations
,
August 2014 in “Wiley interdisciplinary reviews. Developmental biology” This review highlights similarities in the development of thymus and skin epidermis, reporting no new results; the authors emphasize shared molecular mechanisms despite different embryonic origins.