Human Genetic Basis of Coronavirus Disease 2019

The review explored the human genetic basis of COVID-19, highlighting how genetic factors influenced the disease's incidence, severity, and outcomes. Key genetic factors included variants in the ACE, ACE2, TMPRSS2 genes, HLA genotypes, and ABO blood groups, which contributed to individual susceptibility and disease severity. The study emphasized the potential of genetic insights to aid in disease prediction and the development of targeted therapies. It also noted the involvement of the renin-angiotensin-aldosterone system (RAAS) and immune response dysregulation in the pathogenesis of COVID-19. Genetic variants in genes like DPP7, IFITM3, and others were implicated in influencing COVID-19 outcomes. The document highlighted the importance of understanding genetic diversity in developing effective treatments and vaccines for COVID-19.