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This study identified compounds 11d and 11k as potential dual 5α-reductase inhibitors and AR antagonists with significant anti-proliferative effects on prostate cancer cell lines, suggesting they may offer therapeutic value.

This study reported that compounds from the root of Beta vulgaris, specifically 4-picoline and Betalain, showed potential as effective anti-hair loss treatments by demonstrating significant inhibitory activity against the enzyme 5α-reductase in a computational molecular docking study.

This study reported that while no synthesized compounds surpassed finasteride in 5α-reductase inhibitory activity, certain 4-azasteroid-2-oximes exhibited notable inhibition.

This study identified ten novel compounds that may effectively target steroid 5 alpha-reductase 2 (5αR-2) for potential treatment of benign prostate hyperplasia, exhibiting comparable binding energies to existing drugs like finasteride and dutasteride.

This study found that several synthesized compounds were potent inhibitors of human steroid 5alpha-reductase type 2 and reduced prostate weights in treated rats, with compound 15 showing promise for potency in humans.

This study found that novel compounds moderately inhibited 5α-reductase type 1 activity compared to finasteride, offering valuable data on structure-activity relationships.

This study reports that the compound CS-891 can inhibit 5alpha-reductase activity in the dermal papillae of human hair follicles, suggesting potential for treating androgenetic alopecia.

This study found that the compound 9,11-dehydrocortexolone 17alpha-butyrate (CB-03-04) showed strong local antiandrogenic activity in animal models, suggesting potential for treating prostate conditions.

This study found that the compound androstane-17-carboxamide 6 may serve as a lead for new drugs to treat BPH and prostate cancer by reducing the weight of androgen-dependent glands.

This study found that the synthesized compound 7b exhibited higher 5α-reductase inhibitory activity, increased solubility, and dissolution compared to finasteride, suggesting its potential as a lead compound for benign prostatic hyperplasia treatment.

This study evaluated the anti-alopecia activity of compounds from Merremia peltata leaf in rabbits and found that scopolin has a promising effect on hair growth and androgen receptor affinity, potentially offering a new treatment option for alopecia.

This study suggests that novel lipid nanoparticle formulations may be suitable for delivering anti-alopecia compounds like minoxidil and finasteride, although their skin penetration was limited.

This study found that both finasteride and a new steroidal compound, PM-9, competitively inhibit the 5α-reductase enzyme in Penicillium crustosum broth.

This chapter reviews various chemical synthesis methods for pharmaceutical compounds and reports no new experimental results.

This study investigated various synthesized 5-reductase inhibitors and found that compound 6 had the highest anti-androgenic activity and receptor affinity compared to finasteride, showing potential due to its improved efficacy and bioavailability for further research in treating lower urinary tract symptoms.

This review highlights the potential of plant-derived bioactive compounds as an alternative to current hair loss treatments by detailing the mechanisms and clinical evidence of eighteen traditional medicinal plants, and discusses future trends like nanotechnology and stem cell therapy in managing alopecia.

This review explored the potential of medicinal plants and natural compounds as alternative treatments for baldness, identifying several with anti-inflammatory and antioxidant properties that may help reduce hair loss.

This research investigated the design and synthesis of steroid-based compounds as aromatase inhibitors for breast cancer, finding that certain structural modifications significantly enhance their inhibitory potency.

This study found that forsythiaside-A, a natural compound from Forsythia suspensa, was more effective than finasteride at preventing apoptosis of hair cells and delaying the catagen phase entry in an androgenic alopecia mouse model.

This study found that forsythoside A, a compound from Forsythia suspensa, may counteract DHT-induced hair regrowth inhibition by selectively inhibiting TRPV3 channels.

In this study, a novel compound named AH-001 demonstrated effective androgen receptor protein degradation, reducing hair loss progression in a mouse model of androgenetic alopecia, with minimal systemic exposure and side effects, suggesting potential for safer treatment.

This review discusses various targets for treating prostate cancer and benign prostatic hyperplasia and reports on recent studies of new compounds and 5α-reductase inhibitors, but provides no new experimental results.

In this study, researchers reviewed literature on topical delivery of finasteride for androgenetic alopecia, finding that liposomal gels with specific additives showed the highest skin permeation rates, suggesting potential for reducing systemic side effects compared to oral formulations.

This study reports a new industrial process for making finasteride using novel protective groups, demonstrated through spectral data of newly prepared compounds.

This review discusses chemoprevention for prostate cancer and suggests that further open and unbiased investigation into various preventive compounds, including 5α-reductase inhibitors, is needed.

This review explores the potential of carnosic acid, a compound found in rosemary and sage, as a natural alternative treatment for alopecia, highlighting its antioxidant, anti-inflammatory, and hair follicle-regenerative properties, though its poor solubility and stability remain challenges for clinical application.

This research used computational methods to identify potential new treatments for benign prostatic hyperplasia, finding three compounds from Ghanaian plants with promising binding energy against 5alpha reductase 2 compared to existing drugs, yet further in vitro validation is necessary to confirm their efficacy.

In this study, researchers using molecular docking techniques found that 12-Methoxy carnosic acid from rosemary shows promising potential as a natural inhibitor of the 5 alpha reductase enzyme, which is involved in hair loss, suggesting its efficacy compared to finasteride.

This study successfully developed a synthetic route for finasteride that achieves a 30.6% yield and is suitable for industrial production, avoiding the use of expensive or poisonous reagents.

This review article highlights that mesotherapy, a popular non-surgical procedure in aesthetic dermatology, involves injecting a mixture of compounds into the skin for purposes like skin rejuvenation and hair loss treatment, but lacks large-scale studies on its efficacy and safety.