TLDR Chemoprevention, using drugs like finasteride and dutasteride, can help prevent prostate cancer.
The document discussed the challenges of diagnosing and treating prostate cancer, particularly due to its high prevalence, tendency to occur in older age, slow progression, and high treatment costs. It highlighted the potential of chemoprevention as a solution, citing two randomized, controlled studies that demonstrated the effectiveness of 5α-reductase inhibitors (finasteride, dutasteride) in preventing prostate cancer. Additionally, there was growing evidence for the efficacy of other compounds such as selective estrogen receptor modulators (SERMs), NSAIDs, and statins. The review examined the risks and benefits of chemoprevention, including health economic considerations, and concluded that these options should be explored openly and without bias.
16 citations
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June 2008 in “Springer eBooks” Over 50% of women over 50 experience hair loss, with minoxidil being the only proven effective treatment.
July 2018 in “Elsevier eBooks” Frontal Fibrosing Alopecia is a type of hair loss affecting mostly older women, with no agreed best treatment.
16 citations
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October 2007 in “Andrologia” DHT is a strong androgen that may pose less risk to the prostate compared to testosterone.
December 2020 in “Current Sexual Health Reports” Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.
April 2024 in “JCEM case reports” A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.
18 citations
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March 2020 in “Frontiers in Neuroendocrinology” The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
