Deciphering Anti-Alopecia Activity of Polyphenol from Beta Vulgaris Root Against 5α-Reductase: Molecular Insight

    February 2025 in “ Global Academic Journal of Pharmacy and Drug Research ”
    Kasi Pandima Devi, Jitender K Malik, Gyan Singh
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    TLDR Beetroot extract may help treat hair loss naturally with fewer side effects.
    The study explores the anti-alopecia potential of Beta vulgaris (beetroot) root extract, particularly its compounds 4-picoline and betalain, which show significant binding to the 5α-reductase enzyme with binding energies of -4.09 and -7.93 kcal/mol, respectively. This suggests their potential as effective natural inhibitors of the enzyme, which is involved in androgenetic alopecia. The findings propose Beta vulgaris root as a promising alternative treatment with potentially fewer side effects compared to current medications like finasteride and minoxidil, due to its good pharmacokinetic profile and lack of major toxic effects.
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