research Metabolism of Finasteride in Rat Hepatic Microsomes: Age and Sex Differences and Effects of P450 Inducers
Finasteride metabolism varies by age, sex, and P450 inducers, with males processing it faster.
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research The Eosinophilia-Myalgia Syndrome
Eosinophilia-myalgia syndrome, linked to contaminated L-tryptophan supplements, caused severe symptoms and some deaths, with long-term effects in survivors.
research Biology of Melanocytes in Mammals
Melanocytes are important for skin and hair color and protect the skin from UV damage.
research PBX1-SIRT1 Positive Feedback Loop Attenuates ROS-Mediated HF-MSC Senescence and Apoptosis
PBX1 reduces aging and cell death in stem cells by boosting SIRT1 and lowering PARP1.
research Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target
Finasteride may affect PNMT, causing side effects.
research A Cross-Sectional Study of Plasma Trace Elements and Vitamins Content in Androgenetic Alopecia in Men
Men with hair loss may lack zinc, copper, and vitamin D; supplements could help.
research Structure-Guided Manipulation of the Regioselectivity of the Cyclosporine A Hydroxylase CYP-sb21 from Sebekia Benihana
Scientists improved an enzyme to better produce a hair growth-promoting chemical from an immunosuppressant.
research Longer TA Repeat but Not V89L Polymorphisms in the SRD5A2 Gene May Confer Acne Risk in the Chinese Population
Longer TA repeats in the SRD5A2 gene may increase acne risk in Chinese people.
research Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid, and Carnitine-Containing Compound in Prostate and Hair Follicle Cell-Based Assays
The new compound was more effective than finasteride in reducing markers of hair loss and prostate issues in cell tests.
research In Vitro and In Vivo Investigations of the Wound Healing Effect of Crude Spirulina Extract and C-Phycocyanin
Spirulina extract and C-phycocyanin may help heal wounds.
research Pathophysiology of Burn Scars
Burn scars form abnormally due to changes in wound healing, and more research is needed to improve treatments.
research Expression of Type 1 5α-Reductase and Metabolism of Testosterone in Reconstructed Human Epidermis: A New Model for Screening Skin-Targeted Androgen Modulators
The study created a new method to test drugs that affect hormone processing in skin.
research Alternative Therapies for Vitiligo
Some alternative therapies for vitiligo show promise but need more research.
research Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases
Finasteride helps treat skin issues like acne and baldness by blocking testosterone conversion.
research Non-Clinical Safety Evaluation and Risk Assessment of Aleglitazar, a Dual PPAR α/γ Agonist, and Its Major Human Metabolite
Aleglitazar and its major metabolite are safe enough to proceed to Phase 3 clinical trials.
research Hair Loss After Terbinafine Treatment
Terbinafine can cause hair loss.
research Acquired Acrodermatitis Enteropathica in a 28-Year-Old Male with Type 1 Diabetes
A 28-year-old man with type 1 diabetes had skin and hair issues due to zinc deficiency.
research Role of the Wnt Signaling Pathway in Keratoacanthoma
The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.
research Abstracts
The document reports findings on genetic research, including ethical concerns about genome editing, improved diagnosis of mitochondrial mutations, solving inherited eye diseases, confirming gene roles in epilepsy, linking a gene to aneurysms, and identifying genes associated with age-related macular degeneration.
research Telogen Effluvium: A Review
Telogen Effluvium is a common hair loss condition, particularly in women, with no specific FDA-approved treatment, and recovery can take up to 18 months.
research The Role of Dietary Supplements in Hair Loss Treatment: A Review of Evidence
Some supplements may help with hair loss, but there's not enough strong evidence to recommend them without doctor advice.
research Protective Role of Nigella Sativa in Chemotherapy-Induced Alopecia
Black seed oil significantly protects against hair loss from chemotherapy.
research Oral Zinc Sulphate in Treatment of Patients with Thallium Poisoning: A Clinical Therapeutic Trial
Oral zinc sulphate is an effective and safe treatment for thallium poisoning, especially for skin and hair symptoms.
research Syphilis: Today
Syphilis is becoming more common and remains a major health problem due to challenges in prevention and treatment.
research Case 1: Severe Acne – Not Just Skin Deep
Severe acne in a young girl may indicate underlying hormonal issues.
research Chapter 14: Principles of Drug Metabolism
Drug metabolism affects how long a drug works, its interactions, activation, and toxicity, and is influenced by genetics, diet, illness, and other drugs.
research Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)
Genes related to keratin, skin cell differentiation, and immune functions are key in hedgehog skin and spine development.
research Endocrinology, Brain, and Pituitary Gland
Hormones control reproduction and are crucial for body balance.
research NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications
NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
research Cosmeceuticals: The Bioactive Elements in New-Age Beauty Products
Cosmeceuticals are popular for their skin health benefits and anti-aging effects.