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This review highlights the potential of microneedles as a low-cost, well-tolerated method for transdermal drug delivery in dermatology, though further research is needed to establish their clinical efficacy.

This review examines the potential of swellable microneedles in drug delivery and diagnostics, highlighting innovations and challenges in their use for chronic disease treatment, but noting that issues like physiological responsiveness and long-term stability still require research.

This review discusses the potential of gut microbiota-derived exosomes as drug delivery systems and reports no new clinical results; the authors highlight their promise for precision medicine.

This review highlights that while nanoparticle-loaded dissolving microneedles have considerable promise for enhancing transdermal drug delivery, progress is delayed by insufficient understanding of their in vivo behavior, which the authors emphasize as crucial for advancing clinical applications.

This study found that cationic lipid-based formulations enhanced the delivery of large molecules into hair follicles in human scalp skin, with potential to reach pharmacologically active concentrations in the hair bulb.

CUR-loaded micelles improve skin delivery and effects of curcumin for pain and infections.

In this study, researchers developed a new self-administered finasteride delivery system using powder-carrying microneedles that improved hair growth efficacy and addressed safety concerns compared to topical finasteride gel by allowing sustained intradermal release of the drug for three days with a single application.

This review discusses iontophoresis, low-frequency ultrasound, and microneedles for enhancing topical drug delivery in dermatological treatments and reports no clinical results; it emphasizes their mechanisms and potential uses.

This study reported that dandelion herb-derived carbon dots significantly enhanced wound healing in mice with Staphylococcus aureus infections, outperforming a commercial wound healing spray through their antibacterial and dual ROS-modulating capabilities.

This study reports that a novel bioabsorbable nano-micelle hybridized hydrogel scaffold may reduce postoperative melanoma recurrence and mitigate the side effects of doxorubicin in mouse models.

This review paper highlights the development and application of organic and biogenic nanocarriers for delivering bioactives, focusing on eco-friendly and sustainable nanotechnology strategies while addressing challenges like toxicity and paving the way for future innovations in green solution approaches.

This study found that increasing a drug's lipophilicity and adding ethanol to the donor phase can enhance its delivery to the hair follicle, although the precise transport mechanism remains unclear.

This study discusses the potential of thermoresponsive nanogels for improving dermal delivery of therapeutics, highlighting their ability to enhance skin penetration and control drug release with minimal damage to the skin's natural barrier.

In this study, post-treatment with DCO was found to speed up epidermal wound healing after micro-needling of 3D skin models while maintaining the treatment's immunostimulatory benefits, potentially optimizing aftercare and reducing patient recovery time.

This review explores the recent developments and diverse applications of microneedles in drug delivery and diagnostic platforms but reports no new clinical results.

In this study, researchers developed microparticle-embedded gas-propelled microneedles that showed higher drug loading and transdermal delivery efficiency compared to traditional microneedles.

This study reported that the Computational Analysis of Novel Drug Opportunities platform effectively uses integrated biological data, including side effects and pathways, to generate potential drug candidates for colon cancer and migraine disorders.

In this study, researchers found that chitosan-coated PLGA nanoparticles improved the iontophoretic transdermal delivery of the positively charged hydrophilic drug donepezil hydrochloride in an ex vivo rat skin model, achieving 2.2 times higher skin accumulation compared to non-coated nanoparticles.

This review discusses ethosomal delivery systems for topical drugs, highlighting their potential to improve treatment efficacy for conditions like herpes labialis and male pattern baldness, and reports no new clinical results.

This review explores how microneedles can improve the delivery of dermatological treatments by bypassing the skin's outer barrier, discussing their potential use in managing skin diseases, cosmetic applications, and challenges related to clinical adoption.

This review discusses advancements and challenges in bioengineered scaffolds for wound healing but presents no new experimental findings, highlighting their potential and need for further development.

This study examines the role of nanotechnology in cosmetics, highlighting its benefits in improving ingredient solubility and stability, but also noting challenges such as cost, shelf life, and safety concerns, along with regulatory complexities, particularly in harmonizing global legislation.

This review discusses the advancements in using "soft" colloidal nanocarriers for delivering photosensitive agents and highlights their potential applications in treating diseases like cancer, but it reports no new clinical results.

This review discusses the design, properties, and potential applications of smart microneedles, with no new clinical results presented.

This review discusses the role of toll-like receptors in cancer treatment, providing an overview of pre-clinical studies and clinical trials on TLR-targeted therapies and noting the challenges and future prospects.

This review discusses the unique advantages and challenges of microneedle arrays for vaccine and immunotherapy delivery but reports no new clinical results.

This article outlines how nanotechnology strategies, including phospholipid-based nanocarriers like liposomes, could enhance the effectiveness and skin tolerability of acne treatments, aiming to reduce side effects and improve patient compliance in managing acne vulgaris.

This review discusses the integration of biodegradable biomaterials with drugs and stem cells for diabetic wound repair, but reports no new clinical results and highlights the need for further translation to clinical practice.

This review discusses the challenges of traditional phytochemical delivery methods and highlights the potential of microneedles to improve intra/transdermal delivery, reporting no new clinical results.