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This study introduced Cadd4, a peptide-based degrader developed using computer-aided drug design, which effectively reduced PCSK9 levels and increased LDL receptor expression, resulting in decreased plasma cholesterol and LDL-C levels in hypercholesterolemic mice, without liver toxicity.

In this case report, a 33-year-old male with symptoms resembling Neuromyelitis Optica was treated with 10 mg biotin daily, which may reverse certain ophthalmologic and myelopathy findings. The researchers emphasize the need for further research on biotinidase deficiency in patients misdiagnosed with similar conditions.

This protocol paper details methods for live imaging and analysis of dividing germline stem cells in C. elegans and reports no new research findings.

This study found that adding calcitriol to metformin significantly improved symptoms in patients with polycystic ovary syndrome and decreased serum MCP-1 levels compared to metformin alone.

This study indicates that MPZL3 negatively regulates sebaceous gland size in mice by controlling sebocyte proliferation, with implications for disorders like acne and psoriasis.

This paper discusses the diagnostic challenges and treatment options for folliculotropic mycosis fungoides, emphasizing the differing prognoses between its indolent and aggressive subtypes and reporting no new clinical results.

This case report describes a 57-year-old Navy veteran with mild cognitive impairment who showed cognitive improvement and reported better mood after CPAP treatment and medication adjustments.

This study found that PD-MSCs overexpressing PRL-1 inhibited adipogenesis in orbital fibroblasts from Graves' ophthalmopathy patients by modulating key signaling pathways, suggesting a novel therapeutic approach for degenerative diseases.

In this study, porcine collagen acellular dermal matrix scaffolds combined with mice platelet-rich plasma were associated with increased hair density and follicle regeneration in mice with alopecia, suggesting a potential therapeutic approach.

This study investigated optimizing the differentiation process of UC-MSCs into dermal papilla-like tissues for potential hair follicle therapy and highlighted the potential to reduce associated costs by evaluating cell density and growth factors.

In this study of 40 dermatomyositis patients, most with moderate-severe disease at baseline improved over time in a polyphasic pattern, while those with mild disease often remained stable.

This review discusses AMH and ovarian morphology as complementary markers in diagnosing PCOS/PMOS and reports no new clinical results, highlighting the need for a multidomain approach in diagnosis and treatment.

This case report describes a 19-year-old patient with microsatellite stable adrenocortical carcinoma who showed a promising 36-month response to pembrolizumab, including structural and biochemical improvements, with primary adrenal insufficiency as a major side effect.

This study found that metabolism-related genes significantly impact the prognosis and metastasis in breast cancer, and the development of prediction models may guide personalized therapeutic strategies.

This study reports the first known case of multiple type nevus lipomatosus cutaneous superficialis in a 10-month-old girl, with the unique feature of perifollicular fibrosis.

This review discusses various methods for obtaining stem cell-derived conditioned media and its applications in disease treatment, finding generally positive results but highlighting the need for standardized production methods.

CTP-543 is generally safe for treating alopecia areata.

In this study, topical CUR61414 was effective in inhibiting basal cell carcinomas in mice, but no clinical activity was observed in human trials.

In this study, researchers found that skin pigmentation alterations in a mouse model of Carney complex may be caused by specific dermal fibroblasts promoting melanogenic signaling.

Skin-associated cartilage cells can influence hair growth by altering specific signaling pathways.

This source reports a rare case of a 10-year-old child developing periorbital milia as an unusual cutaneous manifestation of chronic graft-versus-host disease following allogeneic stem cell transplantation, suggesting that immune-mediated epidermal disruption may lead to milia formation.

This study found that placenta-derived mesenchymal stem cells overexpressing PRL-1 inhibited adipogenesis in orbital fibroblasts from Graves’ ophthalmopathy patients by modulating specific signaling pathways, suggesting a potential therapeutic strategy.

This study reported that a Megsin-Cre transgene enables genetic manipulation primarily in skin, forestomach, and esophagus tissues, offering a new tool for studying development and diseases in these areas.

This study observed that PCR-based genotyping for cre-loxP mice can lead to errors due to cre-mediated recombination in non-target tissues like tails, affecting the detection of lox alleles.

This study found that PRMT5 inhibitors showed potent anti-tumor activity in models of adenoid cystic carcinoma and that combining these inhibitors with lenvatinib may have additional growth-inhibitory effects.

This case report describes a rare coexistence of primary subcutaneous panniculitis-like T-cell lymphoma and lupus panniculitis in a 20-year-old Moroccan woman, highlighting the importance of repeated biopsies for accurate diagnosis in resistant cases.

In this case report, a 4-year-old Indian girl with linear and annular lupus panniculitis of the scalp achieved complete remission and hair regrowth with oral corticosteroids, showing no relapse after 6 months of follow-up.

In this case report, lichen myxedematosus associated with hepatocellular carcinoma showed progressive improvement in skin lesions without further treatment following tumor resection.

In this case report, researchers describe a 17-year-old African male with an overlapping condition of juvenile dermatomyositis and systemic scleroderma, highlighting the importance of thorough history-taking and physical examination for accurate diagnosis and suggesting early referral to a pediatric rheumatologist to prevent severe outcomes.