16 citations
,
August 2022 in “Drug Testing and Analysis” In this study, transdermal application of anabolic steroids demonstrated rapid and extended detectability in urine, suggesting potential implications for doping control considerations.
October 2023 in “Journal of the American Academy of Dermatology” This source reports that clascoterone cream has been approved in the U.S. for treating acne vulgaris in patients aged 12 and older, suggesting it works by competing with dihydrotestosterone at androgen receptors to mitigate acne's effects.
2 citations
,
May 2021 in “Clinical Pharmacology in Drug Development” This phase 1 study reported that after administering supratherapeutic doses of cortexolone 17α‐propionate, a topical antiandrogen intended for hair loss treatment, there was no effect on the QTc interval, indicating no measurable cardiac safety concerns in the concentration range tested.
441 citations
,
May 2008 in “British Journal of Pharmacology” This article reviews the potential clinical use of anabolic steroids in treating muscle loss from chronic diseases and aging and highlights both the benefits and risks of these substances in sports.
25 citations
,
June 2017 in “Molecular and Cellular Endocrinology” This review discusses the negative effects of anabolic androgenic steroids on various organ systems in men and reports no new results, highlighting the need for physician awareness.
3 citations
,
July 2021 in “Drug Testing and Analysis” This study found that chronic administration of finasteride affected the isotopic composition of testosterone and nandrolone metabolites, impacting the drug-testing outcomes in athletic contexts.
1 citations
,
October 2022 This study assessed the potential for Ocean Thermal Energy Conversion power in Fiji, finding higher power output and efficiency during summer due to greater temperature differences between surface and deep sea waters.
July 2025 in “Medical Science” This review discusses recent studies on the hepatotoxic effects of anabolic androgenic steroids and selective androgen receptor modulators, including liver damage, tumors, and related conditions, and reports no new primary research results.
November 2014 in “John Wiley & Sons, Ltd eBooks” This review discusses hormones that affect acne and highlights a statistically significant link between a low-glycemic-load diet and reduced acne activity, but reports no new experimental findings.
February 2025 in “Prospects in Pharmaceutical Sciences” This source reports that clascoterone cream, a topical androgen receptor inhibitor, has shown effectiveness in treating facial acne vulgaris in patients 12 and older, with clinical trials indicating a favorable safety profile compared to systemic treatments, and potential for broader dermatological applications.
June 2026 in “International Journal of Innovative Technologies in Social Science” This source describes clascoterone, a new topical treatment for acne vulgaris that blocks androgen receptors to reduce sebaceous gland activity and inflammation, offering a lower risk of systemic side effects compared to oral treatments.
1 citations
,
May 2024 in “The Journal of Sexual Medicine” This case report suggests that clomiphene citrate can effectively restore fertility in some men with a long history of anabolic steroid abuse, though individual responses to treatment vary.
4 citations
,
February 2019 in “PubMed” This study found that cortexolone 17α-propionate (clascoterone) effectively inhibited androgen receptor-regulated transcription and IL-6 synthesis in scalp cells, potentially making it a promising candidate for topical treatment of androgenetic alopecia.
11 citations
,
November 2009 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” This study found that bolandiol increased lean body mass and bone mineral density in castrate adult male rats, exhibiting tissue selectivity and acting through multiple receptor pathways with less potency compared to other androgens.
4 citations
,
July 2022 in “Clinical Cosmetic and Investigational Dermatology” This review discusses the clinical trials of clascoterone 1% cream for acne vulgaris and reports no new results; the authors highlight its novel role as a topical antiandrogen.
9 citations
,
April 2021 in “Expert opinion on pharmacotherapy” This review highlights that clascoterone, a newly FDA-approved topical androgen antagonist, effectively reduces both non-inflammatory and inflammatory acne lesions with no systemic effects, making it a promising new option for acne treatment in both male and female patients.
1 citations
,
December 2011 in “Arzneimittelforschung” This study found that the compound 9,11-dehydrocortexolone 17alpha-butyrate (CB-03-04) showed strong local antiandrogenic activity in animal models, suggesting potential for treating prostate conditions.
5 citations
,
May 2020 in “Clinical and Experimental Dermatology” This correspondence discusses clascoterone as a potential new treatment for androgenetic alopecia but reports no clinical results.
27 citations
,
October 2020 in “Drugs” This article reviews the development milestones of clascoterone up to its first approval for treating acne vulgaris, reporting no new clinical results for androgenetic alopecia.
3 citations
,
August 2019 in “Journal of The American Academy of Dermatology” Clascoterone safely promotes hair growth similar to minoxidil.
February 2023 in “Reactions Weekly”
5 citations
,
December 2011 in “Drug Research” This study found that cortexolone 17α-propionate showed strong topical antiandrogenic activity, outperforming progesterone and several known antiandrogens, but lacked systemic antiandrogenic effects in animal models.
16 citations
,
August 2004 in “Tetrahedron” In this study, all stereoisomers of cyoctol were synthesized and tested, revealing that contrary to initial patent claims, cyoctol does not function as an anti-androgen.
23 citations
,
March 2019 in “Environmental Chemistry Letters” This review examines the role of cyclodextrins in improving the solubility, stability, and bioavailability of steroid drugs but does not report new experimental findings.
December 1998 in “Acta Crystallographica Section C-crystal Structure Communications” This study describes the molecular conformation and intermolecular interactions in the crystalline structure of the compound C24H31BrO4.
43 citations
,
July 2017 in “International journal of pharmaceutics” This study found that anionic HSES achieved high complexation efficiencies with various steroids, significantly enhancing their solubility, while specific β-cyclodextrin thioethers showed selective binding to testosterone and estradiol.
January 2025 in “Clinical Cosmetic and Investigational Dermatology” This case series involving 10 patients treated with clascoterone cream 1% for acne vulgaris found it effective and well-tolerated, regardless of severity, age, gender, or ethnicity, and noted additional benefits for related skin conditions.
June 1982 in “Revista Colombiana de Obstetricia y Ginecología” This article discusses treatments for androgenic manifestations using cyproterone acetate alone or with estrogens, but it does not provide new clinical results.
164 citations
,
January 2003 in “Drugs”