This study identified CXXC5 as a key mediator of hair loss induced by PGD2 and DHT via suppression of the Wnt/β-catenin pathway, with implications for potential therapeutic targets.
1 citations
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January 2012 in “生物医学研究杂志:英文版” This study found that cyclosporine A stimulates hair growth in a mouse model by preventing catagen development and increasing expression of certain growth factors.
8 citations
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July 2020 in “BMC genomics” In this study, ceruloplasmin and keratin 4 were identified as markers that differentiate between growing and resting phases in cashmere goat hair follicles, with keratin 4 being a potential marker for the onset of a new hair cycle.
91 citations
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December 2019 in “The EMBO Journal” This study found that the E3 ligases NEDD4 and NEDD4L regulate intestinal stem cell priming by degrading the LGR5 receptor, and their loss leads to increased Wnt activation and crypt proliferation, which in turn accelerates intestinal tumor progression in mice.
March 2022 in “Indian Journal of Animal Research” In this study, canine hair follicle stem cells were shown to be multipotent, capable of differentiating into various cell types like adipocytes in vitro.
3 citations
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March 2023 in “Annals of the New York Academy of Sciences” In this study using mice, simultaneous deficiencies in claudin-1 and claudin-3 were associated with hair loss and altered hair follicle architecture during the telogen phase, suggesting a role in hair retention.
25 citations
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November 2020 in “Proceedings of the National Academy of Sciences” This study found that the HoxC gene cluster plays a critical role in the development of ectodermal organs, including hair and nails, with mammalian-specific enhancers increasing transcription levels during development.
17 citations
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August 1979 in “Journal of The American Academy of Dermatology” This study found that a histochemical stain using 4-dimethyl-aminocinnamaldehyde effectively distinguishes between plucked anagen and telogen hairs by causing the root ends of anagen hairs to develop a red color.
16 citations
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July 2020 in “Advanced functional materials” This review discusses the development and application of cell-derived matrices in regenerative medicine and disease modeling, presenting various fabrication techniques and future perspectives, but reports no new results.
20 citations
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May 2011 in “Journal of Clinical Investigation” In this study, a transgenic mouse model was used to demonstrate that targeted cell loss in different tissues led to varying degrees of regenerative outcomes, including reversible impaired glucose tolerance, irreversible hair loss, and permanent moderate deafness.
87 citations
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July 2009 in “Journal of Cell Science” The researchers found that corneodesmosin is crucial for maintaining skin barrier integrity and hair follicle architecture in mice, with its deletion leading to severe skin and hair abnormalities.
13 citations
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January 2014 in “Aesthetic Surgery Journal” This study found that Cyperus rotundus essential oil is as effective as the Alexandrite laser in reducing the growth of unwanted axillary hair, with notable effectiveness in decreasing white hair growth.
14 citations
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May 2009 in “Journal of the American Academy of Dermatology” This case study describes a patient with discoid lupus erythematosus whose scalp lesions progressed despite treatment, with findings suggesting inclusion cysts and comedones as part of primary or secondary changes.
5 citations
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May 2001 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE” This study developed a double-wavelength laser scanning microphotometer to measure hair shaft and follicle absorbance, improving spatial resolution and reducing light scattering effects in vitro.
September 1998 in “British Journal of Plastic Surgery” This article describes the structure and offerings of microsurgical workshops at Canniesburn Hospital, noting that no new research findings are reported.
16 citations
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August 2004 in “Tetrahedron” In this study, all stereoisomers of cyoctol were synthesized and tested, revealing that contrary to initial patent claims, cyoctol does not function as an anti-androgen.
November 2025 in “Cancer Cell International” This study provides a detailed cellular atlas of cutaneous squamous cell carcinoma, indicating that different fibroblast subtypes play roles in tumor progression and suppression, with potential biomarkers identified for HPV-related tumor growth.
173 citations
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January 2014 in “Nature Cell Biology” This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.
5 citations
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October 2014 in “Methods” This article describes how PESCADOR software assists in creating detailed biological pathway charts from PubMed abstracts, focusing on hair and breast development case studies without providing new clinical results.
7 citations
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December 2020 in “Clinical and Experimental Dermatology” This study found that cepharanthine and its structural analogues may stimulate hair growth by promoting the proliferation of human dermal papilla cells and increasing VEGF expression in vitro.
28 citations
,
August 2018 in “Dermatologic Surgery” This abstract is a listing of affiliations and funding, with no new study or results reported.
January 2015 in “Journal of clinical and investigative dermatology” This study found that clipping is the most effective method for anagen synchronization in adult rat models to mimic chemotherapy-induced alopecia, producing robust anagen phases without causing skin trauma.
4 citations
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July 2010 in “International Journal of Cosmetic Science” This study observed that hair fibers in older women become more curved with age, decreasing hair luster due to their disordered alignment and structural differences between the convex and concave sides.
12 citations
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June 2015 in “Dermatology Reports” This study found that discoid lupus erythematous was the most common type of primary cicatricial alopecia, predominantly affecting middle-aged women.
This study details the presence of two types of cysts in rhino mouse skin, with utricles derived from hair canals and deeper cysts from hair root sheath epithelium.
50 citations
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February 2004 in “Genomics” This study identified a missense mutation in the rat Desmoglein 4 gene, causing abnormal hair shaft development in lanceolate hair mutant rats by disrupting a critical calcium binding site.
25 citations
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January 2006 in “Journal of the European Academy of Dermatology and Venereology” This study reported that a new extraction technique using cautery and forceps is a simple, effective treatment and diagnostic procedure for eruptive vellus hair cysts, with no recurrence after 4 months.
26 citations
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November 2002 in “Planta medica” In this study, the methanol extract of Cercidiphyllum japonicum heartwood was found to stimulate the proliferation of mouse hair epithelial cells, with several isolated compounds showing significant proliferative activities.
July 2019 in “Dermatologic Surgery” This abstract provides contact information for François Kuonen at the Lausanne University Hospital Center and reports no new research findings.
4 citations
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February 2019 in “PubMed” This study found that cortexolone 17α-propionate (clascoterone) effectively inhibited androgen receptor-regulated transcription and IL-6 synthesis in scalp cells, potentially making it a promising candidate for topical treatment of androgenetic alopecia.