Double Mutation of Claudin-1 and Claudin-3 Causes Alopecia in Infant Mice

March 2023 in “ Annals of the New York Academy of Sciences ”

Koya Suzuki, Kosuke Yamaga, Reitaro Tokumasu, Tatsuya Katsuno, Hiroo Tanaka, Shuhei Chiba, Takeshi Yagi, Ichiro Katayama, Atsushi Tamura, Hiroyuki Murota, Sachiko Tsukita

claudin-1 claudin-3 alopecia hair follicles epithelial cell layers telogen phase hair retention epithelial proliferation hair loss hair growth hair regrowth

Studysummary In this study using mice, simultaneous deficiencies in claudin-1 and claudin-3 were associated with hair loss and altered hair follicle architecture during the telogen phase, suggesting a role in hair retention.

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