Double Mutation of Claudin-1 and Claudin-3 Causes Alopecia in Infant Mice

    March 2023 in “ Annals of the New York Academy of Sciences ”
    Koya Suzuki, Kosuke Yamaga, Reitaro Tokumasu … Sachiko Tsukita
    Studysummary In this study using mice, simultaneous deficiencies in claudin-1 and claudin-3 were associated with hair loss and altered hair follicle architecture during the telogen phase, suggesting a role in hair retention.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on onlinelibrary.wiley.com →
    Discuss this study in the Community →

    Research cited in this study 12

    1. Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells Cell · 2020
    2. Telogen Effluvium: A Comprehensive Review Clinical, Cosmetic and Investigational Dermatology · 2019
    3. Mechanical Stretch Induces Hair Regeneration Through the Alternative Activation of Macrophages Nature Communications · 2019
    4. Tight Junction Barriers in Human Hair Follicles – Role of Claudin-1 Scientific reports · 2018
    5. The Role of Tight Junctions in Skin Barrier Function and Dermal Absorption Journal of controlled release · 2016
    6. The Arrector Pili Muscle: The Bridge Between the Follicular Stem Cell Niche and the Interfollicular Epidermis Anatomical Science International · 2016
    7. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    8. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    9. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    10. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    11. Delayed Epidermal Permeability Barrier Formation and Hair Follicle Aberrations in Inv-Cldn6 Mice Mechanisms of development · 2005
    12. Telogen Effluvium: A Comprehensive Review Archives of Dermatology · 1993