research Estimation of Claudin 3 in the Sreum of Alopecia Areata Patients and Its Association with Disease Severity
This study found that plasma Claudin 3 levels were linked to alopecia areata severity among patients compared to healthy controls.
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research 1319 Claudin-1 and -3 maintain proper hair follicle structure and regulate telogen effluvium
This study found that claudins CLDN1 and CLDN3 are crucial for maintaining proper hair follicle structure in mice, and their dysregulation may lead to telogen hair loss.
research Double mutation of claudin‐1 and claudin‐3 causes alopecia in infant mice
In this study using mice, simultaneous deficiencies in claudin-1 and claudin-3 were associated with hair loss and altered hair follicle architecture during the telogen phase, suggesting a role in hair retention.
research Testosterone Reduces Tight Junction Complexity and Down-regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-steroid Replacement Rats
This study found that administering testosterone to ovariectomized female rats decreased endometrial tight junction complexity and expression of specific proteins, potentially affecting embryo implantation.
research Tight Junction barriers in human hair follicles – role of claudin-1
This study demonstrated that tight junction barriers exist in human hair follicles but are less tight in hair follicle keratinocytes than in interfollicular keratinocytes, highlighting claudin-1's key role in follicle barrier function and growth.
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