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The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

The document concludes that hair loss is complex, affects many people, has limited treatments, and requires more research on its causes and psychological impact.

Pregnancy can cause specific skin conditions that need correct diagnosis and treatment to protect both mother and baby.

Hormonal therapy changes skin and hair in transgender patients, who need better researched dermatologic care.

PCOS in lean women is a serious health condition with implications beyond fertility, affecting metabolism and increasing cardiovascular disease risk.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The spiny mouse is a unique menstruating rodent that can help us understand menstruation and reproductive disorders.

Menopause causes significant changes in the vaginal introitus, but less so in the labia majora, which may lead to symptoms of vaginal atrophy.

Gender-affirming hormone therapy changes hair growth in transgender people, with feminizing therapy reducing hair and masculinizing therapy increasing it, but sometimes additional treatment is needed.

Low androgen levels might delay prostate cancer but could lead to more aggressive, therapy-resistant cancers.

Hormone therapy improves mental well-being in transgender individuals but requires ongoing health monitoring.

Topical minoxidil helps transgender individuals assigned female at birth grow more facial hair.

Gender-affirming hormone therapy improves physical performance in trans men to the level of cisgender men, while in trans women, it increases fat mass and decreases muscle mass, with no advantage in physical performance after 2 years.

Vitamin D is important for bones, hair, blood pressure, and breast development.

Eating high-glycemic foods and drinking milk may worsen acne by increasing insulin and IGF-1 levels.

Statins may help treat PCOS by lowering androgen levels and improving cholesterol.

Testosterone replacement is recommended for men with low testosterone levels and symptoms of hypogonadism.

Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.

Menopause worsens skin, hair, and nails, affecting self-esteem and quality of life.

5-alpha reductase inhibitors may help protect the brain and gut in Parkinson's disease.

Vitamin D might help regulate insulin in the body, but taking Vitamin D supplements doesn't clearly prevent or improve type 2 diabetes. More research is needed.

Androgen use may increase the risk of stroke, but more research is needed.

Androgens, male hormones, affect physical and mental functions, with a decrease leading to health issues like muscle loss, bone disease, and depression, and more research is needed on long-term effects and treatments.

Certain gene variations may protect against skin issues and oxidative stress in women with PCOS.

Non-hormonal treatments should be used first for sexual dysfunction in postmenopausal breast cancer patients on aromatase inhibitors, with hormones as a second option.

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

Different types of androgens bind differently to two receptors, AR1 and AR2, in Atlantic croaker's brain and ovarian tissues, suggesting these receptors may control different androgen actions in fish.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.