The Impact of Vitamin D Receptor Gene Polymorphisms (FokI, ApaI, TaqI) in Correlation with Oxidative Stress and Hormonal and Dermatologic Manifestations in Polycystic Ovary Syndrome

September 2024 in “ Medicina ”

Vulcan Talida, Tudor-Sergiu Suciu, Mihaela Iancu, Mitrea Daniela-Rodica, Gabriela Adriana Filip, Lucia Maria Procopciuc

Vitamin D receptor VDR gene polymorphisms FokI ApaI TaqI oxidative stress hormonal manifestations dermatologic manifestations polycystic ovary syndrome PCOS acne seborrhea

TLDR Certain gene variations may protect against skin issues and oxidative stress in women with PCOS.

This study examined the relationship between vitamin D receptor (VDR) gene polymorphisms (FokI, ApaI, TaqI) and oxidative stress, hormonal, and dermatologic manifestations in 46 women with polycystic ovary syndrome (PCOS) compared to 39 controls. It found that the FokI CC genotype significantly reduced the odds of acne (OR = 0.11) and seborrhea (OR = 0.15) in PCOS patients, while the VDR-TaqI dominant genotype was linked to lower oxidative stress levels. The study suggests that specific VDR polymorphisms may protect against certain skin conditions and oxidative stress in PCOS, though further research with larger samples is needed to confirm these findings.

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The Impact of Vitamin D Receptor Gene Polymorphisms (FokI, ApaI, TaqI) in Correlation with Oxidative Stress and Hormonal and Dermatologic Manifestations in Polycystic Ovary Syndrome

Research cited in this study

research Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

research Role of Oxidative Stress in Obese and Nonobese PCOS Patients

research Polymorphisms of Vitamin D Receptor and the Effect on Metabolic and Endocrine Abnormalities in Polycystic Ovary Syndrome: A Review

research Cutaneous Manifestations of Polycystic Ovary Syndrome

research Prevalence of Dermatologic Manifestations and Metabolic Biomarkers in Women with Polycystic Ovary Syndrome in North China

research Cutaneous Manifestations of the Subtypes of Polycystic Ovary Syndrome in Korean Patients

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

research Specific Dermatologic Features of Polycystic Ovary Syndrome and Its Association with Biochemical Markers of Metabolic Syndrome and Hyperandrogenism

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

research The Pathophysiology of Polycystic Ovary Syndrome

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