The Impact of Vitamin D Receptor Gene Polymorphisms (FokI, ApaI, TaqI) in Correlation with Oxidative Stress and Hormonal and Dermatologic Manifestations in Polycystic Ovary Syndrome

    September 2024 in “ Medicina ”
    Vulcan Talida, Tudor-Sergiu Suciu, Mihaela Iancu … Lucia Maria Procopciuc
    🚨 The study is moderately relevant as it involves hormonal and dermatologic manifestations, which can relate to scalp health and hair conditions, but it does not directly address hair loss or alopecia.
    Studysummary This study found that among women with PCOS, the FokI CC genotype of the VDR gene may offer protection against acne and seborrhea, while the VDR-TaqI dominant genotype is associated with reduced oxidative stress.
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    Research cited in this study 11

    1. Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome The Journal of Clinical Endocrinology and Metabolism · 2023
    2. Hirsutism, Normal Androgens, and Diagnosis of PCOS Diagnostics · 2022
    3. Role of Oxidative Stress in Obese and Nonobese PCOS Patients International Journal of Clinical Practice · 2022
    4. Polymorphisms of Vitamin D Receptor and the Effect on Metabolic and Endocrine Abnormalities in Polycystic Ovary Syndrome: A Review Hormone and Metabolic Research · 2021
    5. Cutaneous Manifestations of Polycystic Ovary Syndrome Dermatology Reports · 2021
    6. Prevalence of Dermatologic Manifestations and Metabolic Biomarkers in Women with Polycystic Ovary Syndrome in North China Journal of Cosmetic Dermatology · 2017
    7. Cutaneous Manifestations of the Subtypes of Polycystic Ovary Syndrome in Korean Patients Journal of the European Academy of Dermatology and Venereology · 2014
    8. Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men Journal der Deutschen Dermatologischen Gesellschaft · 2011
    9. Specific Dermatologic Features of Polycystic Ovary Syndrome and Its Association with Biochemical Markers of Metabolic Syndrome and Hyperandrogenism Acta Obstetricia et Gynecologica Scandinavica · 2010
    10. Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome Fertility and Sterility · 2004
    11. The Pathophysiology of Polycystic Ovary Syndrome Clinical endocrinology · 2003