The Impact of Vitamin D Receptor Gene Polymorphisms (FokI, ApaI, TaqI) in Correlation with Oxidative Stress and Hormonal and Dermatologic Manifestations in Polycystic Ovary Syndrome

September 2024 in “ Medicina ”

Vulcan Talida, Tudor-Sergiu Suciu, Mihaela Iancu, Mitrea Daniela-Rodica, Gabriela Adriana Filip, Lucia Maria Procopciuc

Vitamin D receptor VDR gene polymorphisms FokI ApaI TaqI oxidative stress hormonal manifestations dermatologic manifestations polycystic ovary syndrome PCOS acne seborrhea

TLDR Certain gene variations may protect against skin issues and oxidative stress in women with PCOS.

This study examined the relationship between vitamin D receptor (VDR) gene polymorphisms (FokI, ApaI, TaqI) and oxidative stress, hormonal, and dermatologic manifestations in 46 women with polycystic ovary syndrome (PCOS) compared to 39 controls. It found that the FokI CC genotype significantly reduced the odds of acne (OR = 0.11) and seborrhea (OR = 0.15) in PCOS patients, while the VDR-TaqI dominant genotype was linked to lower oxidative stress levels. The study suggests that specific VDR polymorphisms may protect against certain skin conditions and oxidative stress in PCOS, though further research with larger samples is needed to confirm these findings.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

research Recommendations From The 2023 International Evidence-Based Guideline For The Assessment And Management Of Polycystic Ovary Syndrome

8 citations, August 2023 in “The Journal of Clinical Endocrinology and Metabolism”

Follow the latest international guidelines to assess and manage Polycystic Ovary Syndrome effectively.

research Role of Oxidative Stress in Obese and Nonobese PCOS Patients

12 citations, February 2022 in “International Journal of Clinical Practice”

Oxidative stress is higher in women with PCOS, especially if they're obese, and it may increase their risk of heart disease.

research Polymorphisms of Vitamin D Receptor and the Effect on Metabolic and Endocrine Abnormalities in Polycystic Ovary Syndrome: A Review

4 citations, September 2021 in “Hormone and Metabolic Research”

Different forms of the Vitamin D receptor can impact metabolic and hormone issues in Polycystic Ovary Syndrome.

research Cutaneous Manifestations of Polycystic Ovary Syndrome

5 citations, September 2021 in “Dermatology Reports”

Skin problems like acne and excess hair in PCOS are common and linked to being overweight.

research Prevalence of Dermatologic Manifestations and Metabolic Biomarkers in Women with Polycystic Ovary Syndrome in North China

17 citations, September 2017 in “Journal of Cosmetic Dermatology”

Women with PCOS in North China often have hirsutism and acne, with hirsutism linked to metabolic issues.

research Cutaneous Manifestations of the Subtypes of Polycystic Ovary Syndrome in Korean Patients

16 citations, March 2014 in “Journal of the European Academy of Dermatology and Venereology”

Korean patients with PCOS often have skin problems like acne and excess hair, with different symptoms based on their specific PCOS type.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

198 citations, October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft”

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Specific Dermatologic Features of Polycystic Ovary Syndrome and Its Association with Biochemical Markers of Metabolic Syndrome and Hyperandrogenism

research Specific Dermatologic Features of Polycystic Ovary Syndrome and Its Association with Biochemical Markers of Metabolic Syndrome and Hyperandrogenism

67 citations, February 2010 in “Acta Obstetricia et Gynecologica Scandinavica”

Hirsutism is a strong sign of high male hormones and metabolic problems in women with PCOS, but acne and hair loss are not.

research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome

4809 citations, January 2004 in “Fertility and Sterility”

The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.

research The Pathophysiology of Polycystic Ovary Syndrome

249 citations, November 2003 in “Clinical endocrinology”

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Similar Research

5 / 1000+ results

research A Meta-Analysis of the Relationship Between Vitamin D Receptor Gene ApaI Polymorphisms and Polycystic Ovary Syndrome

10 citations, January 2019 in “Advances in Clinical and Experimental Medicine”

Certain variations in the vitamin D receptor gene are linked to an increased risk of polycystic ovary syndrome.

research Vitamin D Receptor Gene Polymorphisms Taq-1 and Cdx-1 in Female Pattern Hair Loss

3 citations, January 2020 in “Indian Journal of Dermatology”

Certain gene variations in the Vitamin D Receptor are linked to higher risk of female hair loss.

research Vitamin D: More Than a Bona Fide Hormone

276 citations, April 2003 in “Molecular endocrinology”

Vitamin D is important for bones, hair, blood pressure, and breast development.

research Vitamin D Receptor Polymorphisms and Polycystic Ovary Syndrome: A Systematic Review

36 citations, January 2017 in “Journal of Obstetrics and Gynaecology Research”

The review found no clear link between vitamin D receptor gene variations and polycystic ovary syndrome.

research Vitamin D Receptor Gene Polymorphism in Chronic Telogen Effluvium: A Case-Control Study

7 citations, October 2019 in “Clinical, Cosmetic and Investigational Dermatology”

Certain gene variations in the Vitamin D receptor may increase the risk of chronic hair loss.