Tru9I Variant as a Novel Genetic Marker for Vitamin D Deficiency in Alopecia Areata
March 2025
in “
Clinical Cosmetic and Investigational Dermatology
”
TLDR The Tru9I variant in the VDR gene may influence alopecia areata risk and vitamin D levels.
This study explores the association between the Tru9I variant in the VDR gene and alopecia areata (AA), involving 72 AA patients and 72 healthy controls. It finds that the U allele is more frequent in AA patients, while the u allele is more common in healthy controls, suggesting a protective effect. The U/U genotype is linked to lower vitamin D levels and VDR gene expression, whereas the u/u genotype is associated with higher levels. These results indicate that the Tru9I variant may affect AA susceptibility and vitamin D metabolism, highlighting the potential for personalized treatment strategies and the need for further research with larger and more diverse populations.