Tru9I Variant as a Novel Genetic Marker for Vitamin D Deficiency in Alopecia Areata

    March 2025 in “ Clinical Cosmetic and Investigational Dermatology ”
    Ghadah Alhetheli, Mohammed Saleh Al‐Dhubaibi, Saleh Salem Bahaj … Ahmed Ibrahim AbdElneam
    Studysummary In this study, researchers found that the "U" allele of the Tru9I variant may be associated with low vitamin D levels and altered VDR gene activity in alopecia areata patients, while the "u" allele might have a protective role against developing the condition.
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    Research cited in this study 10

    1. MiR-200c-3p as a Novel Genetic Marker and Therapeutic Tool for Alopecia Areata Skin Research and Technology · 2024
    2. C-Reactive Protein as a Novel Biomarker for Vitamin D Deficiency in Alopecia Areata Skin research and technology · 2024
    3. VDR Is an Essential Regulator of Hair Follicle Regression Through the Progression of Cell Death Life science alliance · 2023
    4. Vitamin D Deficiency in Patients With Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2017
    5. Alopecia Areata: Overview and Insights from January 2018 Journal of The American Academy of Dermatology · 2017
    6. Efficacy and Safety of Topical Calcipotriol in Management of Alopecia Areata: A Pilot Study Dermatologic Therapy · 2017
    7. Successful Treatment of Alopecia Areata with Topical Calcipotriol Annals of dermatology/Annals of Dermatology · 2012
    8. The Role of Vitamin D Receptor Mutations in the Development of Alopecia Molecular and Cellular Endocrinology · 2011
    9. Vitamin D Receptor Gene Polymorphisms Are Not Associated With Alopecia Areata International Journal of Dermatology · 2007
    10. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006

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    1. Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child International journal of research in dermatology · 2019