Tru9I Variant as a Novel Genetic Marker for Vitamin D Deficiency in Alopecia Areata

March 2025 in “ Clinical Cosmetic and Investigational Dermatology ”

Ghadah Alhetheli, Mohammed Saleh Al‐Dhubaibi, Saleh Salem Bahaj, Sharif Alhajlah, Ahmed Ibrahim AbdElneam

Tru9I variant VDR gene alopecia areata vitamin D deficiency U allele u allele U/U genotype u/u genotype vitamin D metabolism AA VDR

Studysummary In this study, researchers found that the "U" allele of the Tru9I variant may be associated with low vitamin D levels and altered VDR gene activity in alopecia areata patients, while the "u" allele might have a protective role against developing the condition. Our plain-language summary of this paper — not a Tressless recommendation.

This study explores the association between the Tru9I variant in the VDR gene and alopecia areata (AA), involving 72 AA patients and 72 healthy controls. It finds that the U allele is more frequent in AA patients, while the u allele is more common in healthy controls, suggesting a protective effect. The U/U genotype is linked to lower vitamin D levels and VDR gene expression, whereas the u/u genotype is associated with higher levels. These results indicate that the Tru9I variant may affect AA susceptibility and vitamin D metabolism, highlighting the potential for personalized treatment strategies and the need for further research with larger and more diverse populations.

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