April 2023 in “Journal of Investigative Dermatology” This study explores how chromatin differences between dermal papilla cells and papillary fibroblasts contribute to hair follicle inductivity and investigates the regulatory changes in androgenic alopecia.
1 citations
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September 2010 in “UEF eRepo (University of Eastern Finland)” This study provides insight into AR-mediated gene activation and the molecular mechanisms of prostate cancer progression and drug resistance, identifying potential avenues for developing new therapies.
10 citations
,
January 1985 in “PubMed” This study found that electron and proton microprobe analysis can reveal differences in element distribution within human hair and epidermis, although no significant water content differences were noted between atopic eczema and normal skin.
3 citations
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June 2020 in “Developmental Cell” This study observed that in chicken skin, large-scale differences in gene expression between feathered and scaly skin are controlled by enhancer-driven uniform expression, while small-scale differences within individual feathers are associated with chromatin looping.
3 citations
,
September 2017 in “Galen medical journal” This study observed elevated serum homocysteine levels in patients with psoriasis and cutaneous-oral lichen planus compared to healthy controls, but found no significant difference between the two patient groups.
8 citations
,
July 2022 in “International Journal of Molecular Sciences” This study found that in estrogen receptor-positive breast cancer cells, 17β-estradiol repressed polyamine oxidase transcription by interacting with AP-1 sites on its promoter.
11 citations
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May 2021 in “Journal of Medical Virology” This review discusses sex differences in immune response to respiratory viral infections, including SARS-CoV-2, and highlights that hormones like estrogen may provide females with better protection, but it reports no new results.
3 citations
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July 2023 in “Frontiers in Aging” This research detailed a single-cell atlas showing dynamic hair follicle stem cell states associated with the hair cycle during aging in mice, highlighting differences in chromatin landscape linked to stem cell differentiation and quiescence, and providing a foundation for future exploration of aging reversal.
September 2017 in “Journal of Investigative Dermatology” This study found that dermal papilla cells exhibit stage-dependent variation in histone methylation during the hair follicle cycle and display distinct chromatin marker expression when transitioning to in vitro culture.
68 citations
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August 2014 in “PeerJ” This study found that proteomic analysis can distinguish hair samples across different ethnicities and body regions based on keratin protein levels, which may aid forensic hair identification.
32 citations
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September 2016 in “Dermatologic Surgery” This review discusses the current evidence and highlights gaps in research needed for the wider acceptance of low-level laser therapy as a treatment for hair loss; no new clinical results are provided.
197 citations
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January 2019 in “Neuropsychopharmacology” This review discusses sex differences in the neuroendocrine response to stress, focusing primarily on rodent studies, and highlights open questions about the roles of gonadal hormones and sex chromosomes.
113 citations
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July 2020 in “Communications biology” This review suggests that understanding the biological and molecular reasons for more severe COVID-19 in men, particularly those at risk for prostate cancer, could improve management of these patients, but reports no new results.
This study found considerable variation in hair shaft proteomic profiles among Caucasian, African-American, Kenyan, and Korean subjects, with individual and site-specific differences observed.
This study used proteomic profiling to reveal significant individual and site-specific differences in human hair shaft proteins, which may improve the differentiation of hair based on ethnic origin and individual identity.
5 citations
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September 2021 in “Journal of Medical Biochemistry” This study found that Wet-type Age-Related Macular Degeneration patients had higher oxidative stress and HMGB-1 levels compared to healthy controls, suggesting a link to increased tissue inflammation and necrosis.
1 citations
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May 2023 in “Frontiers in Endocrinology” This research suggests that autism's genetic links are partially related to factors influencing physiological sex differences, with rare variants interacting with placental sex differences and common variants affecting steroid-related traits.
321 citations
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March 2015 in “Nature” This study found that super-enhancers are essential for hair follicle stem cell identity, lineage commitment, and plasticity in mice, with SOX9 being a key regulator of these chromatin dynamics.
173 citations
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January 2014 in “Nature Cell Biology” This study found that Wnt signalling activates hair follicle fate in hair follicle stem cells by relieving TCF3/4–TLE-mediated repression, with β-catenin being crucial for this process.
98 citations
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August 2007 in “PLoS ONE” This study found that Myc activation in epidermal stem cells leads to chromatin modifications that promote stem cell exit and differentiation, which can be influenced by HDAC inhibitors like trichostatin A.
June 2023 in “International journal of molecular sciences” In this study, researchers observed that heat stress significantly affected hair and skin traits in two indigenous goat breeds, with Kodi Aadu goats demonstrating greater thermal resilience compared to Kanni Aadu goats, potentially due to differences in gene expression and methylation.
124 citations
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February 2018 in “Nature Reviews Genetics” This review covers recent findings on stem cell plasticity under normal and cancerous conditions but presents no new experimental results, highlighting implications for regenerative medicine and cancer treatments.
11 citations
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January 2017 in “Biochemical and biophysical research communications” This study observed that Cyp27b1−/− mice exhibited growth and skeletal abnormalities similar to those of Vdr−/− mice, despite differences like the development of alopecia in Vdr−/− mice, suggesting that 1α,25D3 may directly influence chondrocyte proliferation and differentiation.
This study found that neonatal administration of finasteride reduced sensitivity to alcohol's motor-stimulating effects and increased preference for novelty and initial alcohol consumption in rats, suggesting a role in alcohol vulnerability.
22 citations
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April 2020 in “Frontiers in Cellular and Infection Microbiology” This study found significant differences in scalp microbiome composition and volatile organic metabolites between individuals with alopecia areata and healthy controls, suggesting potential microbiome-related therapeutic interventions for hair growth disorders.
63 citations
,
December 2010 in “Journal of Endocrinology” This study found that decreased allopregnanolone levels through inhibition or intrauterine growth restriction in guinea pigs were linked to altered brain development markers, suggesting a role for neurosteroids in fetal brain protection and development.
71 citations
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January 2014 in “Journal of Proteome Research” In this study, distinct metabolic profiles were identified in women with PCOS, suggesting potential biomarkers for diagnosis based on changes in lipid and androgen metabolism.
January 2026 in “Preprints.org” This review explores current knowledge on fibroblast lineage specification and its impact on scar-free wound healing, noting that early fetal skin fibroblasts support regeneration, while later developmental shifts lead to fibrosis, highlighting potential strategies to reprogram adult fibroblasts for regenerative repair.
1 citations
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June 2022 in “Frontiers in Neuroanatomy” This study found that neonatal blocking of androgen and estrogen pathways in rats altered sex-specific expression of estrogen and androgen receptors in adult pituitary and adrenal glands, potentially influencing lifelong neuroendocrine function.
4 citations
,
May 2024 in “Biomolecules” This study examined connections between bioelements like Zn, Cu, and Mn in serum and bone tissue and hormone concentrations in men with and without erectile dysfunction, highlighting potential relationships that may help explain ED's etiology.