research Defective Expression of the Gap Junction Protein Pannexin-1 Channel Contributes to the Formation of PCOS-Related Androgenetic Alopecia
Higher levels of the protein Pannexin-1 may play a role in hair loss in women with PCOS.
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research Study of the Composition of 140 Shampoos: Similarities and Differences Depending on the Sales Channel Used
Pharmacy-sold shampoos tend to have fewer allergens compared to those sold in other stores.
research Sodium Metabisulfite: Effects on Ionic Currents and Excitotoxicity
Sodium metabisulfite increases sodium channel activity, leading to higher cell excitability and potential damage.
research K ATP Channels and Cardiovascular Disease
K_ATP channel gene mutations are linked to heart diseases, but more research is needed to understand the connection and treatment potential.
research Rapid Characterization of the Functional and Pharmacological Consequences of Cantú Syndrome KATP Channel Mutations in Intact Cells
Kir6.1 mutations in Cantú syndrome increase channel sensitivity and hyperpolarization, while SUR2B mutations do not.
research KATP Channels in Zebrafish Cardiovascular System: A Model to Study Cantú Syndrome
Zebrafish with mutations similar to human Cantú Syndrome have heart cells with altered channel properties, making them a good model to study the condition.
research PLCD1 and Pilar Cysts
The research linked PLCD1 gene variants to the development of trichilemmal cysts.
research Minoxidil Use in Dermatology, Side Effects, and Recent Patents
Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.
research The Action of Diazoxide and Minoxidil Sulphate on Rat Blood Vessels: A Comparison with Cromakalim
Diazoxide, minoxidil sulphate, and cromakalim relax rat blood vessels by opening K+ channels, with some differences in their actions.
research Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies
Animal models have helped understand hair loss from alopecia areata and find new treatments.
research Mechanism of Action of Minoxidil Sulfate-Induced Vasodilation: A Role for Increased Potassium Permeability
Minoxidil sulfate relaxes muscle by increasing potassium flow, making it a unique muscle relaxer.
research Therapeutic Strategies for Treating Hair Loss
The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.
research Hair Follicle Biology and Topical Minoxidil: Possible Mechanisms of Action
Minoxidil stimulates hair growth by increasing hair thickness and prolonging growth phase.
research Differential Inhibition by Tedisamil and Glibenclamide of the Responses to Cromakalim and Minoxidil Sulphate in Rat Isolated Aorta
Tedisamil and glibenclamide affect cromakalim and minoxidil sulphate differently in rat aorta.
research State-Dependent Signaling by Cav1.2 Regulates Hair Follicle Stem Cell Function
Cav1.2 affects hair growth and could be a target for hair loss treatments.
research Minoxidil Prevents MDMA-Induced Serotonin Depletions: Role of Mitochondrial ATP-Sensitive Potassium Channels, Akt, and ERK
Minoxidil prevents serotonin loss from MDMA by affecting potassium channels and increasing Akt phosphorylation.
research Pharmacological Evidence for the Involvement of Adenosine Triphosphate Sensitive Potassium Channels in Chloroquine-Induced Itch in Mice
ATP-sensitive potassium channels play a role in chloroquine-induced itch in mice.
research Skin and Hair Abnormalities of Cantu Syndrome: A Congenital Hypertrichosis Due to a Genetic Alteration Mimicking the Pharmacological Effect of Minoxidil
Cantu syndrome, which causes excessive hair growth and skin issues, is due to a mutation in the ABCC9 gene, and understanding this could help develop new treatments for hair diseases.
research Androgenetic Alopecia, Trichotrophic Substances, and Histologic Studies of the Human Scalp
Minoxidil promotes hair growth but exact mechanism is unknown.
research A Possible Solution for Hair Loss by Inhibiting Corticotropin-Releasing Factor Receptor from Traditional Chinese Medicine
Caribine from traditional Chinese medicine may help treat hair loss.
research Finasteride Interferes with Prostaglandin-Induced CatSper Signalling in Human Sperm
Finasteride may affect male fertility by interfering with specific sperm signaling.
research Serious Complication of Low-Dose Oral Minoxidil for Hair Loss
Low-dose oral minoxidil can cause serious heart complications.
research From the Microscopic Sweat Gland to Large Datasets: The Power of Quantitative Traits in Dermatology
Using quantitative traits in genetics can improve understanding and management of skin health and conditions.
research Transient Stimulation of TRPMLs Enhances the Functionality of HDPCs and Facilitates Hair Growth in Mice
Activating TRPMLs helps human cells important for hair growth and increases hair growth in mice.
research The Necessity of Investigations to Clarify Sex and Racial Disparities in Pathophysiology of Long COVID
More research is needed to understand sex and racial differences in long COVID.
research 4-Aminopyridine Promotes Accelerated Skin Wound Healing via Neurogenic-Mediator Expression
4-aminopyridine, a FDA-approved drug, speeds up skin wound healing and tissue regeneration.
research Bridging Personal and Population in Excitability Diseases: Will Studies of Rare Diseases Bring Generalizable Mechanisms From Monogenic Channelopathies?
Studying rare genetic disorders can help us understand and treat common diseases better.
research 4-Aminopyridine Promotes Accelerated Skin Wound Healing via Neurogenic-Mediator Expression
4-aminopyridine helps skin wounds heal faster and better.
research Efficacy of Glucopyranosyldiacylglycerol from Padina Arborescens in Preventing Hair Loss
Padina arborescens and its component MOGG may help prevent hair loss through several actions, including blocking a hair loss-related enzyme.
research Repurposing of Drugs as Novel Influenza Inhibitors from Clinical Gene Expression Infection Signatures
Existing drugs, including a blood pressure medication, show promise as new treatments for influenza.