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630-660 / 1000+ resultsresearch Finasteride
research Ligand Based 3D-QSAR Study on a Series of Steroidal Human 5α-Reductase Inhibitors
research Alopecia as an Emerging Adverse Effect Associated With Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists for Weight Loss: A Scoping Review
This review indicates that glucagon-like peptide-1 receptor agonists may be linked to hair loss, raising safety concerns despite the lack of definitive causal evidence.
research Pharmacological Activity of Cepharanthine
The researchers reviewed cepharanthine, a long-used bisbenzylisoquinoline alkaloid, for its antiviral properties, including significant inhibition of SARS-CoV-2. They discussed cepharanthine's other pharmacological actions, highlighted plasma membrane fluidity as a key antiviral mechanism, and examined its safety, bioavailability, and potential for new clinical applications.
research Treatment of scleromyxoedema with hydroxychloroquine
In this study, hydroxychloroquine treatment in patients with scleromyxoedema led to complete or partial remission of skin symptoms and improved mobility, though it did not affect paraproteinaemia.
research Chitosan Nanoparticle-Encapsulated Cordyceps militaris Grown on Germinated Rhynchosia nulubilis Reduces Type II Alveolar Epithelial Cell Apoptosis in PM2.5-Induced Lung Injury
This study found that chitosan nanoparticles containing Cordyceps militaris effectively reduced lung damage in mice exposed to fine particulate matter (PM2.5) by decreasing oxidative stress and preserving lung barrier integrity, suggesting potential as a therapeutic candidate for PM2.5-induced lung diseases.
research Expression and Activity Assay of Human Steroid 5 Alpha-Reductase Type II in CHO Cells
This study found that finasteride effectively inhibits the enzymatic activity of human steroid 5 alpha reductase type II in newly established CHO cell lines.
research Disease modifying osteoarthritis drug discovery using a temporal phenotypic reporter in 3D aggregates of primary human chondrocytes
In this study, researchers developed a novel method combining in silico and in vitro techniques to discover Aromoline, a potential osteoarthritis treatment that increases type II collagen expression in chondrocytes by targeting the dopamine receptor D4.
research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)
This study synthesized and verified the structures of Setipiprant's major and minor metabolites, confirming their regio- and enantioselectivity from earlier proposals in a clinical study.
research Squalene-Containing Nanostructured Lipid Carriers Promote Percutaneous Absorption and Hair Follicle Targeting of Diphencyprone for Treating Alopecia Areata
This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.
research Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway
This study found that strontium ranelate promotes cartilage regeneration in rats by enhancing chondrogenic differentiation of bone mesenchymal stem cells while inhibiting the Wnt/β-catenin signaling pathway.
research Rejuvenating senescent hair follicles: a novel conjugated linoleic acid based nanovesicle approach to treat androgenic alopecia
This study found that MNX@Arg-CLAVs nanovesicles enhanced hair regeneration and reduced aging in hair follicles in AGA mice, with less skin irritation compared to traditional minoxidil tincture.
research A functional study of a case of glucagonoma exhibiting typical glucagonoma syndrome
In this case study, a man with necrolytic migratory erythema and a glucagonoma experienced decreased plasma glucagon levels and reduced metastases after treatment with dimethyltriazenoimidazole carboxamide.
research 75176 A selenium disulfide-based shampoo rebalances the scalp microbiome of subjects of any hair type
research Angle closure in fellow eye with prophylactic pilocarpine treatment
This report discusses the use of intralesional cidofovir and suggests it might be a viable option for treating SCC due to its successful outcome without observed systemic toxicity in this case.
research Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres
This study introduces a novel chitosan-based hydrogel containing cinnamaldehyde-tannic acid-zinc acetate nanospheres, which reportedly enhances wound healing by promoting antibacterial, antioxidant, and anti-inflammatory effects.
research A randomized phase II trial on the addition of dutasteride to combined androgen blockade therapy versus combined androgen blockade therapy alone in patients with advanced or metastatic salivary duct carcinoma – the DUCT study protocol
In this prospective phase II clinical trial, researchers are investigating whether adding dutasteride to combined androgen blockade can improve the response rate and clinical outcomes for patients with androgen receptor-positive recurrent or metastatic salivary duct carcinoma.
research Crystallization Engineering in Aza-Steroid: Application in the Development of Finasteride
This study developed a new crystallization method using solid solution formation to purify finasteride by effectively removing contamination with dihydrofinasteride.
research Alternative synthesis of the anti-baldness compound RU58841
A new, less toxic and more efficient method to create the anti-baldness compound RU58841 was developed in 2014.
research 신선육자환 에탄올 추출물의 항산화 활성
This study found that Sinseon-yukza-hwan extract has strong antioxidative properties, effectively inhibiting free radical generation, which supports its potential use as a natural antioxidant.
research Case of Cronkhite Canada Syndrome - A Non-Inherited Gastrointestinal Polyposis Syndrome
This case report describes a 56-year-old male with chronic watery diarrhea, hyperpigmentation, and alopecia, in whom colonoscopy revealed multiple polypoidal lesions from the distal transverse colon to the rectum.
research CARAWAY, CHINESE CHIVES AND CASSIA AS FUNCTIONAL FOODS WITH CONSIDERING NUTRIENTS AND HEALTH BENEFITS
This review discusses the medicinal and health benefits of caraway, Chinese chives, and cassia, focusing on their antibacterial, antioxidant, antimicrobial, anti-inflammatory, and anticancer properties due to their range of secondary metabolites.
research Non-comedogenic and non-acnegenic hair and scalp care formulations and method for use
research Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α
This study found that palmitoylethanolamide may stimulate allopregnanolone synthesis and reduce oxidative stress in astrocytes through PPAR-α activation, suggesting a neuroprotective role.
research Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss
This study found variable outcomes in hair loss treatment with autologous cell-based therapy using DSC cells, with certain gene markers showing inconsistent correlations with treatment efficacy.
research Abiraterone and spironolactone in prostate cancer: a combination to avoid
This case report suggests that spironolactone may induce prostate cancer proliferation in patients on abiraterone acetate, advising against its use for managing treatment-associated side effects in these individuals.
research Efficacy of albumin-bound paclitaxel combined with nedaplatin in neoadjuvant therapy for esophageal squamous cell carcinoma: A single-center retrospective observational study
This study found that albumin-bound paclitaxel combined with nedaplatin shows promise as neoadjuvant therapy for esophageal squamous cell carcinoma, achieving a high complete response rate with manageable side effects.
research Alopecia Following Deoxycholic Acid Treatment for Submental Adiposity
This letter to the editor reports an observation of alopecia occurring after treatment with deoxycholic acid for reducing submental fat, but it presents no new clinical data or broader conclusions.
research Characterization of Hydrogels of Gelatin/O-Carboxymethyl Chitosan in Ovule Form with Curcumin and Retinyl Palmitate as a Treatment for Cervical Cancer
In this study, researchers developed a mucoadhesive hydrogel ovule containing retinyl palmitate and curcumin for intravaginal use, showing controlled drug release, selectivity against cancerous HeLa cells, and non-toxicity to healthy cells, which may offer a potential treatment for cervical cancer.