27 citations
,
January 2020 in “Experimental Dermatology” This review discusses the role of immune cells in mammalian hair cycle control and highlights their potential relevance to human hair cycling disorders, reporting no new clinical findings.
20 citations
,
January 1995 in “Cells tissues organs” The researchers reported that exposure to long days after short-day treatment induced a synchronized, out-of-season wool growth cycle in New Zealand Wiltshire sheep, similar to cycles induced in other species.
November 2025 in “Frontiers in Cell and Developmental Biology” This study mapped a detailed genetic profile of goat hair follicle apoptosis, identifying key genes and regulatory factors involved in the hair cycle, offering new insights into programmed cell death.
November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study in live mice suggests that hair follicle regression involves apoptosis propagation towards stem cells, potentially slowed by a protective signal from the stem cells themselves.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that in immunodeficient mice lacking T cells, certain innate lymphoid cell subsets increased and influenced the hair growth cycle, with specific ILC subsets shown to promote anagen, the active phase of hair growth.
109 citations
,
April 1997 in “Archives of Dermatological Research” The researchers reported that mast cell and nerve fiber interactions in mouse skin are highly selective for nerve fiber types and vary depending on the hair cycle phase.
5 citations
,
January 2021 in “iScience” Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.
37 citations
,
July 1999 in “The EMBO Journal” Overexpression of certain genes can shorten hair by disrupting the hair-growth cycle.
3 citations
,
July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that K17−/− mice suffered more severe hair follicle damage but showed reduced epidermal inflammation after ionizing radiation, with K17's absence leading to aberrant cell cycle progression due to altered p53 genome binding and reduced B-Myb degradation.
1 citations
,
January 2016 in “Methods in molecular biology” This article reviews a new method to accurately estimate proliferative and migratory epithelial cell numbers post-wounding but reports no experimental findings; the authors suggest its relevance to skin stem-cell biology research.
July 2024 in “Journal of Investigative Dermatology” Human epidermal stem cells divide faster than previously thought.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that inhibiting the Mitochondrial Pyruvate Carrier in human hair follicles ex vivo activated the integrated stress response, affecting cell proliferation and metabolism.
February 1990 in “PubMed” This study observed that hirsute females displayed increased S-phase hair bulb cells and decreased G0/1-phase cells compared to healthy females, with a strong correlation between S-phase percentages and DHEA-S levels.
16 citations
,
March 2019 in “Experimental dermatology” This study found that injury affects the behavior of hair follicle dermal stem cells, steering them towards recruitment into the dermal papilla, a shift influenced by the hair cycle stage.
4 citations
,
January 2014 in “The Scientific World Journal” This study found that deer antler aqueous extract may promote hair growth in mice by extending the anagen phase and increasing cell proliferation in the hair follicle region.
October 2023 in “Oncotarget” In this study using live mice, researchers observed that during hair follicle regression, apoptosis in basal cells may propagate by triggering neighboring cells, potentially regulated by a gradient of pro-survival signals from stem cells, and proposed a testable mechanism to further explore this process.
50 citations
,
May 2020 in “FEBS Letters” This review discusses techniques for analyzing the cell cycle, highlighting emerging tools for measuring cell cycle speed at single-cell resolution in live animals, and reports no new results.
28 citations
,
March 2020 in “Journal of ethnopharmacology” This study found that ginsenoside Rb1 treatment significantly reduced aging symptoms in mice by regulating cell cycle and apoptotic pathways, potentially linked to metabolic changes.
October 2025 in “Clinical Chemistry” This study found that combining Juniperus communis extract with 5-Fluorouracil inhibited oral cancer cell growth more effectively than 5-FU alone, inducing cancer cell death and reducing drug resistance by affecting key cellular pathways and proteins.
March 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study identified the dermal sheath as a driver of hair follicle regression through muscle contraction, essential for reuniting niches and stem cells to regenerate tissue structure during homeostasis.
10 citations
,
January 2020 in “Genes & Diseases” In this study, circ-Smad5 was found to inhibit the proliferation and cell cycle progression of JB6 cells by suppressing Wnt/β-catenin/Lef 1 signaling activation, marking the first report of its function.
2 citations
,
January 2019 in “Recent Advances in Biology and Medicine” This study found that a combination of 5% DMSO and BSA minimizes toxic effects on the cytogenetic stability of dermal papilla cells during cryopreservation.
June 2025 in “International Journal of Nephrology and Renovascular Disease” This study suggests that PLA2R1 overexpression in PMN affects the podocyte cycle and may involve an additional immune response, which could provide new directions for PMN treatment development.
February 2026 in “International Journal of Biological Macromolecules” In this study, researchers developed a novel periodate oxidation method for extracting keratin micro-units from waste hair and feathers, achieving yields of 31.28% and 20.64% respectively, enhancing the stability of oil-in-water emulsions and suggesting potential for sustainable biomaterial production.
18 citations
,
December 2016 in “European journal of pharmacology” In this study, 12-Chloracetyl-PPD showed anti-cancer activity by inhibiting cancer cell viability and inducing apoptosis through reactive oxygen species production without harming normal cells.
20 citations
,
September 1978 in “International Journal of Dermatology” Hair growth is influenced by factors like genetics and nutrition, and more research is needed to understand hair loss and growth mechanisms.
499 citations
,
September 2011 in “Cell” This study found that intradermal adipocyte lineage cells in mice are necessary and sufficient to activate follicular stem cells, highlighting their role in regulating skin stem cell activity.
375 citations
,
February 2006 in “Journal of Cell Science” This article reviews the stages and regulation of the hair cycle, highlighting molecular regulators involved, but it does not present new research findings.
321 citations
,
January 2012 in “Cell stem cell” This study identified TGF-β2 as a crucial signal in hair follicle stem cell regeneration, highlighting its role in counteracting BMP signaling to promote tissue regeneration.
135 citations
,
December 2013 in “Seminars in Cell & Developmental Biology” This review examines the literature on the molecular and cellular makeup of the hair follicle niche and how it influences stem cell behavior during hair regeneration, but does not provide new experimental results.