PLA2R1 Overexpression Causes Podocyte Injury by Inhibiting the Cell Cycle: A Clinical Cross-Sectional Investigation and Cellular Study

June 2025 in “ International Journal of Nephrology and Renovascular Disease ”

Wei Liang, Hua Zhang, Yi Wu, Zhi‐Wei Lai, Weiqiang Zhang, Yuhao Cao, Lishan Tan, Zibo Xiong, Guang Yang, Zuying Xiong

Studysummary This study suggests that PLA2R1 overexpression in PMN affects the podocyte cycle and may involve an additional immune response, which could provide new directions for PMN treatment development.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study investigates the effects of PLA2R1 overexpression on podocyte injury, revealing that it inhibits the podocyte cell cycle, which may contribute to the pathogenesis of primary membranous nephropathy (PMN). The findings suggest that PLA2R1-related PMN could involve an additional immune response, providing new insights that could aid in the development of treatments for PMN.

View this study on dovepress.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Diabetes Mellitus Inhibits Hair Follicle Regeneration by Inducing Macrophage Reprogramming-Mediated Pyroptosis

September 2024 in “Journal of Inflammation Research”

Results are not reported in this abstract, which outlines research investigating why diabetic mice experience suppressed hair follicle stem cell activation, potentially contributing to chronic diabetic wounds.

Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

research Injury-Induced Interleukin-1 Alpha Promotes Lgr5 Hair Follicle Stem Cells Regeneration and Proliferation via Regulating Regenerative Microenvironment in Mice

7 citations , February 2023 in “Inflammation and Regeneration”

This study found that IL-1α promotes hair follicle regeneration and stem cell activation in an age-dependent manner by modulating inflammatory cells and oxidative stress in mice.

Type 2 Diabetes Mellitus Inhibits Skin Renewal Through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

research Type 2 Diabetes Mellitus Inhibits Skin Renewal Through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice

6 citations , April 2022 in “Journal of diabetes research”

This study found that type II diabetes inhibited hair follicle regeneration and skin cell proliferation in mice, potentially explaining reduced skin renewal and chronic wound formation in diabetes.