318 citations,
January 2022 in “Signal Transduction and Targeted Therapy” The Wnt/β-catenin pathway is important for body functions and diseases, and targeting it may treat conditions like cancer, but with safety challenges.
277 citations,
February 2013 in “Science Signaling” Mitochondrial reactive oxygen species are essential for skin and hair development.
276 citations,
April 2003 in “Molecular endocrinology” Vitamin D is important for bones, hair, blood pressure, and breast development.
269 citations,
October 2018 in “International journal of biological macromolecules” Hyaluronic acid is effective for skin rejuvenation and should be a key ingredient in cosmetic products.
263 citations,
February 2020 in “International journal of molecular sciences” ADSCs help in wound healing and skin regeneration but need more research for full understanding.
154 citations,
November 2017 in “Development” Fibroblast Growth Factors (FGFs) are important for tissue repair and regeneration, influencing cell behavior and other factors involved in healing, and are crucial in processes like wound healing, bone repair, and hair growth.
151 citations,
May 2021 in “Frontiers in Medicine” Many patients experience long-lasting symptoms like fatigue and pain after COVID-19, regardless of initial disease severity.
124 citations,
January 1995 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Netherton's syndrome is linked to high IgE levels and unique skin and hair symptoms, and may improve with ammonium lactate lotion and allergy management.
105 citations,
April 2014 in “Trends in Pharmacological Sciences” Targeting the Smoothened receptor shows promise for treating certain cancers.
63 citations,
February 2017 in “ACS biomaterials science & engineering” Polydopamine is a safe, effective, and permanent hair dye that turns gray hair black in one hour.
56 citations,
October 2016 in “Journal of dermatological science” New insights into the causes and treatments for the autoimmune hair loss condition Alopecia areata have been made.
55 citations,
December 2021 in “BMC Veterinary Research” Certain genes in Iranian sheep are linked to wool production and heat adaptation.
54 citations,
June 2020 in “Pharmaceutics” New nanocarriers improve drug delivery for disease treatment.
50 citations,
May 2018 in “International journal of cardiology” Testosterone is linked to cardiovascular risk factors and stroke, but its exact role is unclear.
49 citations,
November 2021 in “Annual review of pathology” Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.
46 citations,
January 2020 in “Research” Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.
46 citations,
May 2013 in “The journal of investigative dermatology/Journal of investigative dermatology” Significant progress was made in understanding PXE, but effective treatments are still needed.
45 citations,
August 2018 in “Journal of Lipid Research” Blocking the ATX-LPA pathway may improve insulin sensitivity and mitochondrial function in obesity.
41 citations,
February 2021 in “Translational research” Non-coding RNAs could help detect and treat radiation damage.
41 citations,
February 2021 in “Cureus” Dutasteride treatment in men with mild to moderate COVID-19 reduced viral shedding, inflammation, and recovery time without serious side effects.
37 citations,
December 2005 in “Dermatology Online Journal” Women under 55 with hair loss (AGA) may have a higher risk of heart disease (CAD).
32 citations,
July 2017 in “Molecular diagnosis & therapy” MicroRNA-21 could help diagnose and treat skin fibrosis.
31 citations,
August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
30 citations,
February 2022 in “Pharmaceutics” 3D bioprinting improves wound healing by precisely creating scaffolds with living cells and biomaterials, but faces challenges like resolution and speed.
29 citations,
March 2021 in “Frontiers in Endocrinology” Testosterone may influence COVID-19 severity and outcomes.
29 citations,
November 2011 in “Cell stress & chaperones” Quercetin effectively treated and prevented hair loss in mice.
23 citations,
October 2009 in “Gastroenterology” Vitamin D is crucial for bone health and preventing serious diseases.
22 citations,
April 2022 in “Stem cell research & therapy” Hair follicle-derived extracellular vesicles may help heal chronic wounds as effectively as those from adipose tissue.
21 citations,
June 2022 in “Molecules” Perilla frutescens, an East Asian plant, contains 400 bioactive compounds that have various health benefits, including anti-inflammatory, antidepressant, and anticancer effects, and can treat conditions like diabetes, skin allergies, and neurological disorders.
20 citations,
August 2022 in “Frontiers in Immunology” Fibroblasts are important in healing diabetic wounds, but high sugar levels can harm their function and slow down the healing process.