Search
for

    Did you mean Cancer Stem Cells?
    Glossary Cancer Stem Cells

    small subset of tumor cells that can self-renew and differentiate

    Cancer Stem Cells (CSCs) are a small subset of cells within a tumor that possess the ability to self-renew and differentiate into various cell types found in the cancer. These cells are thought to be responsible for tumor growth, metastasis, and recurrence after treatment, making them a critical target for cancer therapies.

    Related Terms

    Sort by

    Research 30 of 1000+

    1. Porcine epidermal stem cells as a biomedical model for wound healing and normal/malignant epithelial cell propagation Theriogenology · 2006 · 42 citations
    2. HPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell Expansion Journal of Investigative Dermatology · 2017 · 25 citations
    3. Normal stem cells and cancer stem cells: similar and different Seminars in Cancer Biology · 2010 · 126 citations
    4. Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling PloS one · 2014 · 56 citations
    5. Understanding Cancer Cells of Origin in Cutaneous Tumors Elsevier eBooks · 2016 · 1 citations
    6. Montagna Symposium 2015: Harnessing Stem Cells to Reveal Novel Skin Biology and Disease Treatments Journal of Investigative Dermatology · 2016
    7. Biochemistry of epidermal stem cells Biochimica et Biophysica Acta (BBA) - General Subjects · 2012 · 26 citations
    8. Cell-intrinsic mechanisms governing stem cell quiescence and regulating cancer progression in mammalian skin CU Scholar (University of Colorado Boulder) · 2015
    9. Cell death as an architect of adult skin stem cell niches Cell death and differentiation · 2024
    10. Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia Stem cell research & therapy · 2024
    11. The dual role of stem cell-specific Bcl-2 function for epidermal regeneration and cancer 2019
    12. Spatiotemporal Labeling of Melanocytes in Mice International Journal of Molecular Sciences · 2018 · 4 citations
    13. Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing PLOS ONE · 2012 · 23 citations
    14. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015 · 129 citations
    15. Metabolic Teamwork in the Stem Cell Niche Cell metabolism · 2017 · 14 citations
    16. The circadian molecular clock creates epidermal stem cell heterogeneity Nature · 2011 · 293 citations
    17. Epidermal stem cell lineages Advances in stem cells and their niches · 2019 · 1 citations
    18. The Dynamic Duo: Niche/Stem Cell Interdependency Stem Cell Reports · 2015 · 31 citations
    19. The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function Oncogene · 2022 · 3 citations
    20. Stem cell identification-<i>in vivo</i> lineage analysis versus <i>in vitro</i> isolation and clonal expansion The Journal of Pathology · 2012 · 17 citations
    21. The role of Kindlin-1 in skin homeostasis and tumor development Max Planck Digital Library · 2014
    22. Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of β-catenin in mice Genes & Development · 2008 · 556 citations
    23. Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas Publisher · 2019
    24. Melanocyte stem cells in the skin: Origin, biological characteristics, homeostatic maintenance and therapeutic potential Clinical and Translational Medicine · 2024 · 27 citations
    25. Stem and progenitor cells in sebaceous gland development, homeostasis and pathologies Experimental dermatology · 2021 · 19 citations
    26. Abstract 4385: Live-imaging the interface between homeostasis and cancer initiation Cancer research · 2016
    27. Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate Genes · 2019 · 28 citations
    28. The genetic evolution of skin squamous cell carcinoma: tumor suppressor identity matters Experimental Dermatology · 2016 · 6 citations
    29. Exploiting the origins of Ras mediated squamous cell carcinoma to develop novel therapeutic interventions Small GTPases · 2011 · 3 citations
    30. Hedgehog signalling in skin development and cancer Experimental Dermatology · 2006 · 190 citations