Normal Stem Cells and Cancer Stem Cells: Similar and Different

April 2010 in “ Seminars in Cancer Biology ”

Mark Shackleton

stem cells cancer stem cells cell proliferation self-renewal cancer propagation cancer stem cell model clonal evolution model interconversion model genomic integrity tumorigenic cells cellular differentiation

Studysummary This review discusses the similarities and differences between normal stem cell proliferation and cancer cell oncogenesis and concludes that understanding these mechanisms could improve cancer treatment strategies, but it reports no novel findings.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

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research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

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research Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog

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