25 citations
,
June 2017 in “Journal of Investigative Dermatology”
This study found that in a transgenic mouse model, β-HPV infection led to increased skin thickness and proliferation of specific keratinocyte stem cells, which may contribute to squamous cell carcinoma development.
126 citations
,
April 2010 in “Seminars in Cancer Biology”
This review discusses the similarities and differences between normal stemcell proliferation and cancercell oncogenesis and concludes that understanding these mechanisms could improve cancer treatment strategies, but it reports no novel findings.
This study found that selective androgen receptor modulators (SARMs) significantly inhibited tumor growth and metastasis-promoting factors in AR-positive triple-negative breast cancermodels.
April 2016 in “Journal of Investigative Dermatology”
This symposium reviewed various topics in stemcell research related to skin biology, including mechanisms of skin regeneration, tumorigenesis, and pathways influencing melanoma stemcell behavior, but it reported no new clinical results.
Hair loss treatments like Minoxidil, finasteride, and stemcell therapies exist, but a complete cure is hindered by genetic complexity and market dynamics. Cloning hair follicles is considered a potential solution, but it's currently not feasible.
Hair loss treatments still rely heavily on minoxidil, finasteride, and RU58841, with little innovation. Future treatments like stemcell therapy and RNA technology show promise but are not yet available.
RU58841 may pose cancer risks due to its antiandrogen properties and lack of long-term safety data. Using it is considered a high-risk experiment with unknown potential for harm.
Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.
miR-205, a tiny RNA, can stimulate hair growth by softening aging hair follicle stem cells in mice. Future tests aim to see if this can work in humans.