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This study found that the phytosterols β-sitosterol, stigmasterol, and campesterol have low-to-negligible inhibitory activity against steroidal 5α-reductase type 2 compared to the synthetic inhibitor dutasteride, with β-sitosterol showing the highest activity among the tested phytosterols.

In this study, in silico screening and molecular simulations identified β-sitosterol and brassicasterol as stable potential inhibitors of 5α-reductase1, suggesting they could be explored for androgenic alopecia treatment.

This study found that aeroponic cultivation significantly increased the growth and bioactive compound content of Cannabis Sativa roots compared to soil cultivation.

This study suggests that Acrotrema arnottianum, a herb used in traditional medicine, contains biologically active metabolites like squalene and α-Tocopherol. It showed antibacterial effects against Staphylococcus aureus and antifungal properties against Candida albicans, while demonstrating antioxidant activity.

This study evaluated compounds from Jatropha cordata bark, finding that a sterol mixture and n-heptyl ferulate demonstrated notable anti-inflammatory activity in murine macrophage cells without toxicity, suggesting potential for treating chronic inflammation.

This study examined the evolutionary and functional homology of steroid 5α-reductase and DET2 proteins, identifying protists as a common ancestor, and discovered a new subclass DET2-like in plants, potentially involved in polyprenol reduction.

This review discusses the potential benefits of pumpkin seed oil for men's health, particularly in conditions such as benign prostatic hyperplasia, overactive bladder, and androgenic alopecia, but reports no new clinical results.

This study found that inhibiting 5α-reductase in molluscs provokes a specific shell morphology, suggesting gastropods might have unique 5α-reductase substrates absent in vertebrates.

This study analyzed the affinity, stability, and pharmacokinetics of compounds from Sansevieria trifasciata, reporting that three compounds showed promising molecular docking results against the androgen receptor and satisfactory pharmacokinetic profiles, similar to minoxidil, in an in-silico setting.

This review examined moringa seed oil's potential to combat alopecia, reporting that its phytosterol and fatty acid compounds may block dihydrotestosterone formation and support healthy hair growth.

This chapter reviews the uses and evidence for saw palmetto in treating lower urinary tract symptoms in men with benign prostate hyperplasia, but finds no strong support for its effect on hair loss.

This review examines the pharmacological evidence and bioactive compounds in Hibiscus plants, supporting their potential importance for developing treatments for chronic and degenerative diseases, though more research is needed.

This review discusses the properties and therapeutic potentials of beta-sitosterol, highlighting a need for more detailed studies on its mechanisms and long-term effects in humans; it reports no new results.

This review evaluates and classifies the non-saponin components of Korean Red Ginseng, emphasizing their combined role with saponins in the plant's bioactivity, but reports no new clinical results.

This review discusses advancements in plant cell culture technology for producing potent natural cosmetic ingredients and reports no new experimental results.

This review surveys the chemical composition and various uses of jojoba oil in medicine and industry but presents no new clinical results.

This review compiles studies on the antidiabetic potential of plants from the Middle East, particularly from the Asteraceae and Lamiaceae families, but reports no clinical results.

In this study, rice bran supercritical CO2 extract demonstrated potential to promote hair growth in mice, increasing hair follicles and growth factor expression, similarly to 3% minoxidil.

In this study, petroleum ether extract of Citrullus colocynthis fruit effectively promoted hair growth in a mouse model of androgen-induced alopecia, showing comparable results to the standard treatment, finasteride.

The EFSA panel concluded that coriander seed oil is safe for use as a novel food ingredient at the proposed intake levels for healthy adults.

This review discusses the ethnobotanical uses and phytochemistry of Plumbago zeylanica L., highlighting its potential pharmacological benefits for conditions such as diabetes and cardiovascular disorders, but reports no new experimental findings.

This review highlights the traditional use and potential therapeutic activities of Asiasari Radix in drug discovery, but it reports no new clinical results.

This review discusses the role of inheritance, androgens, and microinflammation in androgenetic alopecia and suggests some plant-based folk remedies may help address these factors but reports no new clinical results.

This review discusses the functional and nutraceutical importance of wheat straw, emphasizing its bioactive compounds and potential benefits, and reports no new experimental findings.

In this animal study, petroleum ether and ethanolic extracts of Abrus precatorius seeds appeared to reverse androgen-induced alopecia in male albino rats by inhibiting the 5α-reductase enzyme, similar to finasteride.

This study reports that a 100% herbal hair dye composed primarily of Cymphomandra betacea, Tagetes erecta, and Aloe vera gel provides permanent hair color without causing hair damage, loss, or skin irritation compared to synthetic dyes.

This review explores the phytochemistry and phytopharmacology of Urtica dioica but reports no new experimental findings, focusing on its traditional uses and range of bioactive constituents.

This study found that Caesalpinia bonduc seed extracts significantly reduced prostate weight and improved prostate tissue morphology in Wistar rats with testosterone-induced benign prostatic hyperplasia.

In this study, saw palmetto supplements showed varied effects on cell growth in vitro and did not significantly inhibit growth in the hamster flank organ model despite a notable trend.

This article reviews treatment options for androgenetic alopecia, highlighting potential uses of plant materials, but reports no new clinical results.