7 citations
,
January 2023 in “Frontiers in Cell and Developmental Biology” This review provides a comprehensive overview of apoptosis-related molecules in head development, highlighting caspases' roles and associated abnormalities in tissues like the brain, sensory organs, skin, and bones, without reporting new results.
5 citations
,
January 2023 in “Cell proliferation” This study reported that supplementing rat hair follicle stem cells with chick embryo extract enhanced their migration and proliferation, possibly promoting differentiation toward Schwann cells.
5 citations
,
April 2022 in “Frontiers in Medicine” This study summarizes the signaling molecules and extracellular components involved in epithelial–mesenchymal interactions, enhancing our understanding of hair follicle regeneration and skin wound healing, but reports no new experimental results.
4 citations
,
February 2024 in “The Journal of Urology” This study reports that adding androgen deprivation therapy to salvage radiation therapy for patients with non-metastatic biochemical recurrence of prostate cancer after radical prostatectomy improves progression-free survival, particularly in those with higher post-prostatectomy PSA levels.
3 citations
,
September 2023 in “Skin research and technology” This review article highlights the potential of mesenchymal stem cells, their exosomes, and non-coding RNAs in repairing aging skin tissues due to their ability to secrete beneficial compounds, suggesting their promising role in photoaging treatment without causing immune rejection or granuloma formation.
3 citations
,
June 2023 in “MedComm” This study summarizes the role and potential applications of stem cell exosomes in skin and bone healing, highlighting their regenerative capabilities and suggesting innovative delivery methods like nanoliposomes and hydrogels to improve bioavailability and therapeutic outcomes.
3 citations
,
December 2022 in “npj Regenerative Medicine” This review discusses the role of heparan sulfate proteoglycans in regulating stem cell fate and highlights their potential as targets for addressing hair loss, without reporting new clinical results.
This study found that hair follicles across mouse skin form a heterogeneous regenerative field, with distinct cycling dynamics influenced by the balance of activator and inhibitor signals, which could inform other organ regeneration research.
3 citations
,
May 2013 in “International journal of molecular sciences” This review discusses the biological characteristics and potential of epidermal stem cells in orthopedic regenerative medicine but reports no new experimental findings.
2 citations
,
July 2019 in “Journal of lasers in medical sciences” In this study, researchers found that treating dermal papilla cells with synovial fluid and laser photobiomodulation increases the expression of chondrocyte marker genes, indicating potential promotion of chondrogenic differentiation.
This study found that TLR2 and its ligand CEP are crucial for maintaining hair follicle health and stimulating hair growth, with deficiencies observed in aging and obesity potentially reducing regeneration.
This review summarizes the current applications and mechanisms of self-assembled peptide hydrogels in promoting skin, bone, and nerve regeneration, highlighting their potential due to their biocompatibility and supportive role in tissue healing.
44 citations
,
June 2017 in “The EMBO Journal” This study reports that the autotaxin–LPA–LPA3 signaling pathway at the embryo-epithelial boundary plays a critical role in decidualization by up-regulating HB-EGF and COX-2 in the uterine epithelium.
December 2024 in “Frontiers in Neurology” In this pilot randomized clinical trial, TRT combined with finasteride increased lean mass, muscle size, and bone mineral density without prostate enlargement in men with spinal cord injury, suggesting potential benefits for body composition and musculoskeletal health.
January 2018 in “General internal medicine and clinical innovations” In this review, the researchers found no statistically significant difference in overall survival and disease-free survival between busulfan/cyclophosphamide and total bone irradiation conditioning regimens for acute myeloid leukemia patients.
15 citations
,
January 2013 in “European Journal of Pediatrics” Patients with Shwachman-Diamond syndrome often get misdiagnosed due to a wide range of symptoms, including immune system problems and bone abnormalities.
January 2016 in “Journal of Materials Chemistry B” Advancements in biomaterials and nanotechnology are improving medical applications like hair growth, bone regeneration, and cancer treatment.
73 citations
,
June 2010 in “PLoS Genetics” This study identified that a deficiency in the palmitoyl transferase enzyme, due to a mutation in the Zdhhc13 gene, led to severe physiological abnormalities in mice, including skin, bone, and systemic amyloid issues.
11 citations
,
July 2015 in “Gene” This study found that dihydrotestosterone (DHT) suppresses prostaglandin E2 and TGF-β induced IGF-I gene promoter activity in osteoblasts, suggesting complex interactions among bone growth regulators and potential complications from anabolic steroid use.
10 citations
,
May 2020 in “Clinical and Experimental Health Sciences” This study found that Tideglusib at 50nM stimulated Type-I collagen production in human gingival fibroblasts and osteoblasts, suggesting potential benefits for bone regeneration.
May 2026 in “Scientific Reports” This study found that a bioactive borosilicate glass containing Sr and Cu ions exhibited promising mechanical strength, biocompatibility, and antibacterial activity, particularly the CuSr-1 wt.% composition, suggesting potential for use in orthopedic implants and bone tissue engineering.
September 2023 in “Frontiers in bioengineering and biotechnology” This review explores the role of JAG1 in disease treatment, highlighting the need for effective methods to deliver JAG1 in its bound form to activate NOTCH signaling for therapeutic applications in craniofacial bone loss and myocardial infarction.
January 2023 in “Annali di stomatologia” This review traces the development and application of Platelet-rich Plasma in regenerative medicine, emphasizing its role in tissue healing and bone regeneration, but reports no new clinical results.
28 citations
,
August 2000 in “Current Opinion in Chemical Biology” This article reviews current osteoporosis treatments, focusing on the potential of selective androgen receptor modulators and other agents to enhance bone formation, but provides no new clinical data.
245 citations
,
January 2018 in “Bone Research” This review discusses the role of TGF-β signaling in stem cell recruitment and tissue regeneration, indicating that abnormalities in TGF-β activation contribute to various major diseases and suggesting avenues for therapeutic intervention.
53 citations
,
November 2014 in “International Journal of Oncology” This study found that wedelolactone, a natural compound from plants, inhibited breast cancer-mediated osteoclast differentiation and activity in vitro, suggesting its potential as a therapy for bone destruction in breast cancer bone metastasis.
October 2025 in “The Scientific Issues of Ternopil Volodymyr Hnatiuk National Pedagogical University Series pedagogy” This study reviews modern techniques for bone tissue regeneration, addressing challenges like inadequate bone volume for dental implants, and highlights emerging methods such as guided bone regeneration, distraction osteogenesis, and stem cell therapy; it emphasizes the importance of personalized strategies tailored to individual patient needs.
23 citations
,
October 2009 in “Gastroenterology” This article reviews the multifaceted roles of vitamin D beyond bone health and notes its potential involvement in reducing risks of certain cancers and autoimmune diseases, but it presents no new clinical results.
January 2024 in “Wiadomości Lekarskie” This study analyzing 40 pediatric patients treated for head and neck sarcomas in a Polish clinic from 2015-2022 found rhabdomyosarcoma was the most common type, requiring complex oncological and surgical treatment, often involving reconstructive techniques.
September 2011 in “Clinical Biochemistry” This article discusses how recent research suggests that aggressive video games have little effect on aggression and violence among players, calling for professional organizations to update their policy statements accordingly.