Gene Expression Analysis of Chondrogenic Markers in Hair Follicle Dermal Papilla Cells Under the Effect of Laser Photobiomodulation and Synovial Fluid
July 2019
in “
Journal of lasers in medical sciences
”
laser photobiomodulation synovial fluid hair follicle dermal papilla cells cell proliferation gene expression analysis chondrogenic differentiation osteogenic differentiation low-level laser irradiation laser treatment joint fluid hair follicle cells cell growth gene study cartilage formation bone formation low-level laser therapy
TLDR Laser treatment and synovial fluid can change hair follicle cells to resemble joint cells, with the changes being more significant when both treatments are used together.
In 2019, a study was conducted to examine the effects of laser photobiomodulation and synovial fluid on hair follicle dermal papilla cells. The cells were isolated from rat whisker hair follicles and treated with a laser, synovial fluid, or both. The results showed that laser treatment increased cell proliferation, while synovial fluid treatment significantly changed cell morphology to resemble cultured articular chondrocytes by day 4. Gene expression analysis revealed an up-regulation of all genes until day 14 post-treatment, with the most significant increase in gene markers seen in cells treated with both laser and synovial fluid. The study concluded that synovial fluid could induce chondrogenic and/or osteogenic differentiation in dermal papilla cells, a process that appears to be enhanced by low-level laser irradiation. However, further research is needed to confirm these findings and explore their potential therapeutic applications.
