46 citations
,
May 1995 in “Proceedings of the National Academy of Sciences” This study demonstrated that a specific 9-kbp fragment of the bovine keratin 6 gene effectively directs tissue-specific and inducible expression in transgenic mice, suggesting potential applications for targeted gene therapy in hyperproliferative skin conditions.
45 citations
,
August 2009 in “American Journal Of Pathology” Noggin promotes skin tumors by activating certain cell signaling pathways.
44 citations
,
October 2017 in “British Journal of Dermatology” This review discusses the broadening scope of botulinum toxin applications beyond traditional uses, highlighting its effects on non-neuronal cells and potential in treating various dermatological conditions, without reporting new clinical findings.
44 citations
,
June 2017 in “The EMBO Journal” This study reports that the autotaxin–LPA–LPA3 signaling pathway at the embryo-epithelial boundary plays a critical role in decidualization by up-regulating HB-EGF and COX-2 in the uterine epithelium.
43 citations
,
December 2013 in “Stem Cells” Stretching skin increases a certain protein that attracts stem cells, helping skin regeneration.
43 citations
,
September 2006 in “Annals of Plastic Surgery” This article presents a unique case of hair-thread tourniquet syndrome in a 3-month-old, with a hair causing bony erosion of the toe, and includes a literature review and meta-analysis.
41 citations
,
September 2010 in “Journal of dermatological science” This study suggests that mesenchymal stem cell-induced dermal papilla-like tissues can generate new hair follicles in mice, indicating potential for developing hair cell therapy using stem cells.
41 citations
,
October 2008 in “The American journal of pathology” This study found that reducing BMP signaling in mouse nipple epithelia, achieved through Noggin overexpression, can convert them into hairy skin with pilosebaceous units.
39 citations
,
March 2008 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that GLI2 plays a key role in activating follistatin, an activin/BMP antagonist, in response to hedgehog signaling in human epidermal cells, with implications for hair follicle development and basal cell carcinoma.
39 citations
,
August 2001 in “Clinical endocrinology” This study found that lean women with PCOS have a similar degree of tissue insulin resistance as obese women with PCOS, suggesting that insulin resistance may be a primary feature of the syndrome.
38 citations
,
June 2018 in “International Journal of Oral and Maxillofacial Surgery” Both bone donor sites had low long-term issues and high patient satisfaction.
38 citations
,
November 2013 in “Journal of The American Academy of Dermatology” This study found that higher BMI was significantly associated with more severe hair loss in men with male-pattern and early-onset androgenetic alopecia.
37 citations
,
December 2024 in “Theranostics” In this study, a newly developed nanoparticle-loaded hydrogel wound dressing demonstrated significant antibacterial, antioxidant, anti-inflammatory, and proangiogenic activities, effectively reducing pain and promoting healing in a murine burn wound model while preventing infection by *Staphylococcus aureus*.
37 citations
,
June 2011 in “Journal of Cellular Biochemistry” In this study, transgenic male mice over-expressing the androgen receptor in mesenchymal stem cells showed reduced fat mass and improved glucose clearance, suggesting enhanced androgen sensitivity may alter body composition.
37 citations
,
March 2010 in “Veterinary dermatology” This study reports a case of bovine besnoitiosis in Germany characterized by specific skin lesions, with diagnosis confirmed through histopathology, serology, and PCR as Besnoitia besnoiti.
37 citations
,
May 2002 in “PubMed” In this study, long-term use of finasteride did not negatively impact bone mineral density in men with benign prostatic hyperplasia over a 4-year period.
36 citations
,
April 2013 in “Cell and Tissue Research” Bone-marrow and epidermal stem cells help heal wounds differently, with bone-marrow cells aiding in blood vessel formation and epidermal cells in hair growth.
30 citations
,
December 2017 in “Advanced Healthcare Materials” This study reports that using nanogel and layer-by-layer self-assembly to encapsulate single dermal papilla cells can form cell spheroids that regenerate hair follicles successfully in a hair follicle regeneration model.
29 citations
,
April 1995 in “Endocrinology” In this study, finasteride treatment did not negatively impact bone development or density in male rats, suggesting that DHT deficiency is not harmful to the male rat skeleton.
28 citations
,
December 2016 in “Journal of Biomedical Materials Research Part A” This study found that mesenchymal progenitor cells from human hair roots seeded onto polymer scaffolds stimulated the production of mineralized proteins, enhancing bone-like structures, with optimal results at a pore size of 35 µm.
28 citations
,
November 2013 in “Cell and Tissue Research”
28 citations
,
August 2013 in “Facial Plastic Surgery Clinics of North America” This article discusses using body and beard hair for hair restoration and reviews the indications, techniques, and risks involved, but reports no new clinical results.
26 citations
,
July 2005 in “Optometry and vision science” This case report documents unilateral madarosis and facial alopecia as potential adverse effects of botulinum A toxin injections in a patient treated for left oromandibular dystonia.
26 citations
,
January 1994 in “Hormone and Metabolic Research” This study found that one year of antiandrogen treatment with spironolactone significantly decreased bone mineral density in young women with androgen excess.
25 citations
,
May 2016 in “Progress in Biophysics & Molecular Biology” This article reviews the role of R-spondins and their receptors in bone development and metabolism, highlighting their potential modulatory effects and clinical implications for treating bone loss diseases, but reports no new clinical results.
25 citations
,
October 1993 in “American Journal of Physical Anthropology” This study observed that in Namibian/Southern African men, hormone levels, particularly estradiol, influence the growth of body hair, with different effects noted in various ethnic groups.
24 citations
,
January 2017 in “Journal of Cutaneous and Aesthetic Surgery” In this pilot study, botulinum toxin was found to be a safe and effective treatment for androgenetic alopecia in most participants, though larger studies are needed to confirm these findings.
24 citations
,
December 2010 in “Dermatologic surgery” In this study, BTXA injections did not effectively treat recalcitrant alopecia areata or improve hair regrowth in most patients, suggesting its limitations as an alternative therapy.
23 citations
,
September 2021 in “Clinical Cosmetic and Investigational Dermatology” This review discusses the dermatological applications of botulinum toxin, including off-label uses for various skin conditions, and calls for a better understanding of underlying muscular anatomy for effective clinical practice.
23 citations
,
December 2015 in “Anais Brasileiros de Dermatologia” This study identified two distinct histological patterns in permanent alopecia following bone marrow transplantation, suggesting links to myeloablative chemotherapy and chronic graft-versus-host disease.