April 2023 in “International Journal of Pharmaceutics” In this study, melatonin-loaded Pickering emulsions stabilized by chitosan-dextran sulphate nanoparticles and enhanced with lecithin showed improved photostability, antioxidant activity, and follicular delivery in androgenic alopecia-affected rats, potentially rivaling commercial minoxidil for hair loss treatment.
January 2023 in “The Egyptian Journal of Hospital Medicine” This study found that type A botulinum toxin treatment significantly increased hair thickness and reduced vellous hair count in patients with androgenetic alopecia, suggesting its potential as an effective therapy.
June 2022 in “Journal of Cosmetic Dermatology” This study found that combining botulinum toxin A injections with finasteride and minoxidil increased hair density in patients with androgenic alopecia more effectively than finasteride and minoxidil alone.
January 2022 in “Journal of Cosmetics, Dermatological Sciences and Applications” This study found that applying SERUM THICKER increased hair density significantly over six months in individuals with mild to moderate androgenetic alopecia, with greater efficacy from daily use.
December 2021 in “Intisari Sains Medis” This case report describes a 29-year-old woman with Female Pattern Hair Loss whose hair thinning reduced one month after botulinum toxin treatment.
July 2020 in “Journal of The American Academy of Dermatology” This article discusses the authors’ response to comments on their study about intradermal botulinum toxin's effect on androgenetic alopecia, reporting no new findings.
This study concluded that bone morphogenetic proteins are crucial for hair follicle stem cell differentiation and that their downregulation by androgens may contribute to the development of androgenetic alopecia.
September 2017 in “Journal of Investigative Dermatology” This study found that Bone morphogenetic proteins (BMPs) play a crucial role in dermal papilla cells' ability to induce hair follicle stem cell differentiation, and that androgens may impair this process by downregulating BMPs.
August 2014 in “Aesthetic Surgery Journal” This review covers current hair restoration techniques, medical treatments for hair loss, and emerging trends like hair cloning, but reports no new clinical findings.
This study found that in men with male-pattern androgenetic alopecia in Taiwan, a higher body mass index is associated with more severe hair loss.
August 2013 in “Nature Reviews Drug Discovery” A protein called FGF9 helps regenerate hair follicles in mice after skin damage, and increasing FGF9 could potentially help human hair growth.
306 citations
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August 2011 in “Journal of cachexia, sarcopenia and muscle” This study found that GTx-024 significantly increased total lean body mass and improved physical function in healthy elderly men and postmenopausal women, suggesting potential use for muscle wasting conditions.
278 citations
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March 2013 in “Gut” In this study, nearly 5% of anti-TNF-treated patients with IBD developed psoriasiform skin lesions, with smoking identified as a main risk factor, and ustekinumab proved highly effective in severe cases.
255 citations
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October 1985 in “The Journal of Clinical Endocrinology & Metabolism” This study concluded that albumin-bound testosterone is biologically important and significantly contributes to testosterone bioavailability in women receiving spironolactone.
201 citations
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August 2006 in “Cell and Tissue Research”
152 citations
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January 2004 in “Current anthropology” Humans lost body hair relatively recently in evolution.
139 citations
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May 2020 in “Stem Cell Research & Therapy” In this study, human bone marrow mesenchymal stem cell-derived exosomes significantly accelerated cutaneous wound healing in rats by modulating the TGF-β/Smad signaling pathway.
115 citations
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August 2008 in “The Journal of Clinical Endocrinology & Metabolism” In this study, T3 and T4 were found to directly influence human hair follicles in vitro, enhancing keratinocyte proliferation, prolonging the hair growth phase, and affecting pigmentation.
93 citations
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January 2016 in “British Journal of Dermatology” This study found that patients with acne vulgaris had higher serum IGF-1 levels and more intense FoxO1 and mTOR expression than controls, suggesting their role in acne pathogenesis.
69 citations
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February 2008 in “The American journal of pathology” This study found that local injections of interleukin-4 and neutralizing anti-interferon-γ antibody effectively treated alopecia in a mouse model, suggesting potential therapeutic pathways for human alopecia areata.
57 citations
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June 1999 in “Dermatologic surgery” This review discusses various hair removal methods, focusing on laser-assisted systems, and reports no new clinical results.
46 citations
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September 2022 in “International Journal of Environmental Research and Public Health” This study found that COVID-19 vaccine booster dose acceptance was high in the East Mediterranean Region, especially among those informed by the Ministry of Health, but concerns about benefits and side effects influenced rejection.
45 citations
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February 2001 in “Joint bone spine” This study found that Turner’s syndrome is associated with significant bone mass decrease due to estrogen deficiency, which can be improved with estrogen therapy, while bone issues in Klinefelter’s syndrome may benefit from early androgen therapy and possibly bisphosphonates.
45 citations
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January 1977 in “Advances in experimental medicine and biology” Hair follicles have an enzyme that converts arginine to citrulline in proteins.
40 citations
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January 2017 in “Intestinal Research” This study found that among Japanese IBD patients, the NUDT15 p.Arg139Cys variant was significantly associated with thiopurine-induced leukopenia and severe hair loss, suggesting its genotyping is important for predicting these adverse events.
39 citations
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June 2012 in “Journal of Structural Biology” Disulfide bonds are crucial for hair structure during keratinization.
39 citations
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November 1984 in “Journal of Cardiovascular Pharmacology” Minoxidil lowers blood pressure, increases heart rate, and improves blood flow in dogs.
37 citations
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March 1998 in “Lupus” This case report describes a patient with SLE and APLS who developed basaloid follicular hamartomas, which persisted despite aggressive treatment for SLE, although hair regrowth occurred.
26 citations
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May 1984 in “Journal of Parenteral and Enteral Nutrition” In this study, a 54-year-old woman with short bowel syndrome developed biotin deficiency and associated symptoms while on home parenteral nutrition lacking biotin, which improved significantly after supplementation.
22 citations
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August 2019 in “Environmental research” This study found that the Pseudomonas sp. T5-6-I strain significantly increased selenium accumulation and root hair density in Brassica oleracea, highlighting its potential for phytoremediation and biofortification.