10 citations
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November 2010 in “Journal of Pharmacy Practice” This article discusses polycystic ovary syndrome, highlighting treatment approaches for managing insulin resistance, hyperandrogenism, and fertility issues, but reports no new clinical results.
September 2016 in “Hair transplant forum international” This abstract provides author information and location affiliations for a study conducted in Bangkok, Thailand, but it does not include reported results or study details.
May 2025 in “Journal of Photochemistry and Photobiology B Biology” In this study, researchers observed that blue LED irradiation enhanced cosmetic permeation, increased diameter, and improved resistance of hair fiber in Caucasian and Asian ethnic groups, whereas African hair showed less change.
This study observed that methylene blue, a mitochondrial-targeted antioxidant, promotes hair follicle stem cell proliferation and viability through reduced oxidative stress and enhanced β-catenin signaling, and it may also protect against hair loss related to glucagon-like peptide-1 receptor agonists by reducing metabolic stress.
April 2024 in “Frontiers in cellular and infection microbiology” This review highlights evidence supporting the potential of blue light therapy as a non-invasive treatment for managing skin and hair conditions by modulating interactions between the skin microbiome and its host.
13 citations
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January 2021 in “The American journal of gastroenterology” In this study, sirolimus treatment reduced the size of venous malformations and improved anemia, transfusion dependence, and quality of life in patients with blue rubber bleb nevus syndrome, though mild adverse effects were reported.
3 citations
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January 2025 in “Biomaterials Science” In this study, blue light-irradiated nanovesicles derived from human adipose-derived stem cells enhanced dermal fibroblast proliferation and extracellular matrix synthesis, improving skin maintenance and hair follicle regeneration, suggesting a novel therapeutic strategy for skin and hair disorders.
1 citations
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December 2023 in “Cutis” This systematic review found that toluidine blue may be valuable for diagnosing and treating specific skin tumors in the context of Mohs micrographic surgery, though literature on its use is limited and mostly qualitative.
February 2025 in “Cosmetics” This narrative review explored how blue light therapy may offer therapeutic benefits for various skin disorders by affecting microbial activity and immune responses, promoting hair growth, and aiding skin rejuvenation and healing.
23 citations
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July 2021 in “Life” This review evaluates the potential benefits and mechanisms of blue light therapy for skin conditions like atopic dermatitis and acne, but highlights the need for further research on safety and clinical protocols.
20 citations
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April 2020 in “Journal of advanced Biomedical and Pharmaceutical Sciences” This study investigated the use of methylene blue in a niosomal hydrogel for photodynamic treatment of acne and found that it led to significant improvement in inflammation compared to IPL treatment.
2 citations
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February 2022 in “Biology” This study found that blue laser irradiation reduced ATP levels and cell viability in mouse skin by increasing oxidative stress through the production of reactive oxygen species.
10 citations
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September 2022 in “Journal of Biophotonics” This study analyzed clinical and histological reports and concluded that blue light therapy is safe for human skin, with potential photoprotective effects against UV irradiation due to its impact on skin pigmentation mediated by Opsin-3.
41 citations
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October 2024 in “Nature Communications” In this study, researchers developed a wearable red and blue LED patch and a sprayable fibrin gel to treat infected wounds at home, demonstrating effective infection control and enhanced wound healing in diabetic mice and minipigs.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that low-dose blue light (453nm) may positively affect hair growth by interacting with the receptors CRY1 and OPN3 in hair follicle cells.
26 citations
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June 2023 in “International Journal of Bioprinting” In this study, an innovative composite hydrogel incorporating methylene blue-loaded nanoparticles was developed for 3D-printed wound dressings, showing improved mechanical properties, excellent antibacterial effects, and enhanced skin healing in mice.
23 citations
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June 2021 in “Lasers in Medical Science” In this study, blue light therapy at a specific wavelength increased hair density and shaft width in 90% of patients with androgenetic alopecia after 10 weeks.
January 2026 in “Materials Today Bio” This study demonstrated that a multifunctional hydrogel containing Prussian blue nanozymes and an ultrasound-responsive nitric oxide donor improved healing in diabetic wounds by reducing oxidative stress, promoting angiogenesis, and enhancing tissue repair in animal models.
October 2025 in “Animals” This study reported that horses with pituitary pars intermedia dysfunction had improved coat condition, advanced shedding, and better quality of life when treated with blue light masks.
24 citations
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June 2020 in “Industrial Crops and Products” This study reports that biomass activated carbon fibers derived from metaplexis japonica seed hair effectively adsorb methylene blue dye, demonstrating high capacity and rapid adsorption performance.
This study suggests that a combination of blue light photobiomodulation and biomimetic peptide infiltrations may effectively increase hair density in patients with androgenetic alopecia.
September 2017 in “Journal of Investigative Dermatology” In this study, low-dose 453 nm blue light appeared to enhance hair growth by interacting with specific photoreceptors in the outer root sheath cells.
3 citations
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March 2013 in “QScience Connect” This study found that low power He:Ne laser and methylene blue successfully damaged hair follicles in mice while preserving the epidermis, suggesting a potential for improved long-term hair removal options.
August 2025 in “Aesthetic Cosmetology and Medicine” In this article, researchers explored how blue light exposure affects the scalp and hair follicles, highlighting oxidative stress and hair growth disruptions, while emphasizing the importance of protective strategies like antioxidants and limiting light exposure.
December 2025 in “Journal of Inflammation Research” This study found that BAMO acupuncture combined with Simiao pill can help restore normal prostate tissue structure in mice by reducing DHT production, promoting apoptosis, and decreasing inflammatory responses.
This study found that exposure to Prussian Blue caused significant detachment of cuticle segments from the hair shaft in both new and aged human hairs.
160 citations
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December 2016 in “Journal of biophotonics” This review discusses the evolution and potential of photobiomodulation therapy, highlighting its transition from skepticism to recognition in medical research; it reports no new experimental findings.
March 2026 in “Food Science and Biotechnology” In this study, oral administration of blue honeysuckle fruit extract was found to promote hair growth in mice by enhancing dermal papilla cell proliferation and activating β-catenin signaling, suggesting its potential use as a food or cosmetic product for hair regeneration.
This study found that Polygonum multiflorum radix ethanol extract may promote melanin synthesis, potentially helping to turn gray hair back to black by enhancing antioxidant activity and increasing tyrosinase expression.
8 citations
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November 2020 in “Optics and Laser Technology” This review discusses the applications and advantages of LED-based photobiomodulation therapy for dermatological and cosmetic purposes but highlights existing challenges and health concerns while exploring future perspectives.